Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis

Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk

(2020) Olga Tatsiy et al.   Frontiers in Immunology

Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial

(2020) Bruno François et al.   INTENSIVE CARE MEDICINE

Serum citrullinated histone H3 concentrations differentiate patients with septic verses non-septic shock and correlate with disease severity

(2020) Yuzi Tian et al.   INFECTION

Neutrophils and NETS in modulating acute and chronic inflammation

(2019) Fernanda Vargas e Silva Castanheira et al.   BLOOD

Citrullinated Histone H3 is a Potential Diagnostic and Prognostic Biomarker in Septic Patients

(2019) Yuzi Tian et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Citrullinated histone 3 causes endothelial barrier dysfunction

(2018) Jamie E. Meegan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock

(2018) Lucie Jolly et al.   CARDIOVASCULAR RESEARCH

TREM-1 multimerization is essential for its activation on monocytes and neutrophils

(2018) Kevin Carrasco et al.   Cellular & Molecular Immunology

Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice

(2018) Yong Zou et al.   Oncotarget

Triggering Receptor Expressed on Myeloid cells-1: a new player in platelet aggregation

(2017) Lucie Jolly et al.   THROMBOSIS AND HAEMOSTASIS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Differential Use of Human Neutrophil FcγReceptors for Inducing Neutrophil Extracellular Trap Formation

(2016) Omar Rafael Alemán et al.   Journal of Immunology Research

Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype

(2016) Antonina Akk et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

(2016) Paula Giselle Czaikoski et al.   PLoS One

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

(2016) Shuai Liu et al.   Scientific Reports

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

(2015) Christine B. Read et al.   JOURNAL OF IMMUNOLOGY

Origin of Circulating Free DNA in Sepsis: Analysis of the CLP Mouse Model

(2015) Shigeto Hamaguchi et al.   MEDIATORS OF INFLAMMATION

Simplified Human Neutrophil Extracellular Traps (NETs) Isolation and Handling

(2015) Sara Najmeh et al.   Jove-Journal of Visualized Experiments

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

NADPH Oxidase Promotes Neutrophil Extracellular Trap Formation in Pulmonary Aspergillosis

(2014) Marc Röhm et al.   INFECTION AND IMMUNITY

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

Admission Cell Free DNA Levels Predict 28-Day Mortality in Patients with Severe Sepsis in Intensive Care

(2014) Avital Avriel et al.   PLoS One

In Vivo Characterization of Neutrophil Extracellular Traps in Various Organs of a Murine Sepsis Model

(2014) Koji Tanaka et al.   PLoS One

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Role of Neutrophil Extracellular Traps Following Injury

(2014) Fu-Chao Liu et al.   SHOCK

Citrullinated histone H3: A novel target for the treatment of sepsis

(2014) Yongqing Li et al.   SURGERY

Attenuation of Responses to Endotoxin by the Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor LR12 in Nonhuman Primate

(2013) Marc Derive et al.   ANESTHESIOLOGY

Distinct Signaling Cascades of TREM-1, TLR and NLR in Neutrophils and Monocytic Cells

(2013) Steve Prüfer et al.   Journal of Innate Immunity

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs

(2013) Marc Derive et al.   SHOCK

Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis

(2012) M. Derive et al.   JOURNAL OF IMMUNOLOGY

TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

(2012) R. J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death

(2010) Anurag Kumar Gupta et al.   FEBS LETTERS

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Signaling Pathways of the TREM-1- and TLR4-Mediated Neutrophil Oxidative Burst

(2009) Philipp Haselmayer et al.   Journal of Innate Immunity

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock

(2008) K. Saukkonen et al.   CLINICAL CHEMISTRY

The TREM-1/DAP12 pathway

(2008) Anja S. Tessarz et al.   IMMUNOLOGY LETTERS