Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

(2020) Yingying Zhang et al.   DISEASE MARKERS

Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation

(2020) Lei Wei et al.   Nature Microbiology

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel DNA repair-related prognostic signature predicting survival of patients with hepatocellular carcinoma

(2019) Na Li et al.   Cancer Management and Research

Early Nuclear Events after Herpesviral Infection

(2019) Florian Full et al.   Journal of Clinical Medicine

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

(2019) Morimoto et al.   Genes

How cells ensure correct repair of DNA double-strand breaks

(2018) Joonyoung Her et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

(2018) Kouichi Kitamura et al.   PLoS Pathogens

Virus DNA Replication and the Host DNA Damage Response

(2018) Matthew D. Weitzman et al.   Annual Review of Virology

Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus

(2018) Subramaniyam Ravichandran et al.   PLoS Pathogens

Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1

(2018) Hong Xu et al.   NUCLEIC ACIDS RESEARCH

Regulation of Structure-Specific Endonucleases in Replication Stress

(2018) Seong Min Kim et al.   Genes

Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins

(2017) Satoko Iwahori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of structure-specific endonucleases to maintain genome stability

(2017) Pierre-Marie Dehé et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase

(2017) Xi-Juan Liu et al.   PLoS Pathogens

Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses

(2015) Myriam Scherer et al.   JOURNAL OF VIROLOGY

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

DNA repair mechanisms and human cytomegalovirus (HCMV) infection

(2014) Beata Smolarz et al.   FOLIA MICROBIOLOGICA

The human cytomegalovirus IE1 protein: past and present developments

(2014) Myriam Scherer et al.   Future Virology

The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses

(2014) Xiaofei E et al.   Viruses-Basel

Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions

(2014) Myriam Scherer et al.   PLoS Pathogens

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Human cytomegalovirus immediate early proteins promote degradation of connexin 43 and disrupt gap junction communication: implications for a role in gliomagenesis

(2013) Zahidul Khan et al.   CARCINOGENESIS

Small ubiquitin-related modifier (SUMO) pathway-mediated enhancement of human cytomegalovirus replication correlates with a recruitment of SUMO-1/3 proteins to viral replication compartments

(2013) M. Scherer et al.   JOURNAL OF GENERAL VIROLOGY

DNA viruses and the cellular DNA-damage response

(2012) A. S. Turnell et al.   JOURNAL OF GENERAL VIROLOGY

Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

(2012) Zhigang Guo et al.   MOLECULAR CELL

Stimulation of Homology-Directed Repair at I-SceI-Induced DNA Breaks during the Permissive Life Cycle of Human Cytomegalovirus

(2011) A. S. Kulkarni et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Infection Causes Degradation of Sp100 Proteins That Suppress Viral Gene Expression

(2011) Y.-E. Kim et al.   JOURNAL OF VIROLOGY

FEN1 Ensures Telomere Stability by Facilitating Replication Fork Re-initiation

(2010) Abhishek Saharia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing of Lagging-Strand Intermediates In Vitro by Herpes Simplex Virus Type 1 DNA Polymerase

(2010) Y. Zhu et al.   JOURNAL OF VIROLOGY

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding

(2010) Zhigang Guo et al.   Nature Chemical Biology

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

(2010) Dorjbal Dorjsuren et al.   NUCLEIC ACIDS RESEARCH

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

Flap Endonuclease 1 Contributes to Telomere Stability

(2008) Abhishek Saharia et al.   CURRENT BIOLOGY

Nucleolar Localization and Dynamic Roles of Flap Endonuclease 1 in Ribosomal DNA Replication and Damage Repair

(2008) Z. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY