Mechanisms of differential desensitization of metabotropic glutamate receptors

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

(2020) Miriam Stoeber et al.   eLife

Chronic treatment with morphine disrupts acute kinase-dependent desensitization of GPCRs

(2020) Emily R Leff et al.   MOLECULAR PHARMACOLOGY

Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors

(2020) Joon Lee et al.   Cell Reports

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function

(2020) Amr Ellaithy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

(2019) Vanessa A Gutzeit et al.   eLife

Separation of Acute Desensitization and Long-Term Tolerance of µ-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation

(2019) Seksiri Arttamangkul et al.   MOLECULAR PHARMACOLOGY

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

(2019) Sanghyeon Lee et al.   eLife

Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo

(2019) Amanda Acosta-Ruiz et al.   NEURON

Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

(2019) Nicky Scheefhals et al.   Cell Reports

G protein-coupled receptor kinases: Past, present and future

(2018) Konstantin E. Komolov et al.   CELLULAR SIGNALLING

GPCR desensitization: Acute and prolonged phases

(2018) Sudarshan Rajagopal et al.   CELLULAR SIGNALLING

Metabotropic glutamate receptor trafficking

(2018) Young Ho Suh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Molecular mechanism of GPCR-mediated arrestin activation

(2018) Naomi R. Latorraca et al.   NATURE

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

(2018) Andreas Reiner et al.   NEURON

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

(2018) Elke Miess et al.   Science Signaling

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

(2018) Elke Miess et al.   Science Signaling

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

(2018) Amélie S. Tora et al.   NEUROPHARMACOLOGY

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

Single-molecule diffusion-based estimation of ligand effects on G protein–coupled receptors

(2018) Masataka Yanagawa et al.   Science Signaling

EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms

(2018) Weston Stauffer et al.   Scientific Reports

Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function

(2017) Max E. Joffe et al.   MOLECULAR PSYCHIATRY

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

(2017) Yuri K. Peterson et al.   PHARMACOLOGICAL REVIEWS

Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling

(2017) Ana Neto et al.   Pigment Cell & Melanoma Research

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X

(2017) Laura J. Stoppel et al.   Cell Reports

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(2016) Susanne Nuber et al.   NATURE

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

(2016) Joshua Levitz et al.   NEURON

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling

(2016) Andrew G. Eng et al.   Nature Communications

Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway

(2016) Nazish Abdullah et al.   Cell Reports

Conformational dynamics of a class C G-protein-coupled receptor

(2015) Reza Vafabakhsh et al.   NATURE

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Molecular mechanisms that desensitize metabotropic glutamate receptor signaling: An overview

(2012) Luisa Iacovelli et al.   NEUROPHARMACOLOGY

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

(2011) Todd D Prickett et al.   NATURE GENETICS

An Expanded Palette of Genetically Encoded Ca2+ Indicators

(2011) Y. Zhao et al.   SCIENCE

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

(2011) Supachoke Mangmool et al.   Toxins

Nonenzymatic Rapid Control of GIRK Channel Function by a G Protein-Coupled Receptor Kinase

(2010) Adi Raveh et al.   CELL

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

(2010) Etienne Doumazane et al.   FASEB JOURNAL

The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation

(2010) Andrew C. Emery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Phosphorylation-independent Regulation of Metabotropic Glutamate Receptor 5 Desensitization and Internalization by G Protein-coupled Receptor Kinase 2 in Neurons

(2009) Fabiola M. Ribeiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Group I Metabotropic Glutamate Receptor Trafficking and Signaling by the Caveolar/Lipid Raft Pathway

(2009) A. Francesconi et al.   JOURNAL OF NEUROSCIENCE

Regulation of Group II Metabotropic Glutamate Receptors by G Protein-Coupled Receptor Kinases: mGlu2 Receptors Are Resistant to Homologous Desensitization

(2009) L. Iacovelli et al.   MOLECULAR PHARMACOLOGY