Article
Chemistry, Multidisciplinary
Zhi-Chao Hu, Ben Wang, Xiao-Gang Zhou, Hai-Feng Liang, Bing Liang, Hong-Wei Lu, Yu-Xiang Ge, Qing Chen, Qi-Wei Tian, Feng-Feng Xue, Li-Bo Jiang, Jian Dong
Summary: This study developed a Golgi apparatus-targeted photodynamic strategy to activate NLRP3 and found that it promoted the release of proinflammatory contents, enhancing innate immunity and tumor immunogenicity. Pyroptosis led to immunogenic cell death, promoted dendritic cell maturation, and effectively activated antitumor immunity and long-lived immune memory.
Article
Immunology
Hannan Ai, Fanmei Meng, Yuncan Ai
Summary: Characterizing immune landscapes at the systems level is important in modern medicine. This article introduces the PathwayKO platform, which integrates advanced methods of pathway enrichment analysis, statistics analysis, and visualizing analysis to conduct cutting-edge integrative pathway analysis and decipher target KO signaling pathways. The platform is demonstrated to comprehensively analyze real-world mouse KO transcriptomes and effectively evaluate the performance of pathway analysis methods. These advances in deciphering biological insights at the systems-level have potential applications in bioinformatics and systems immunology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ryotaro Oyama, Harumichi Ishigame, Hiroki Tanaka, Naho Tateshita, Moeko Itazawa, Ryosuke Imai, Naomasa Nishiumi, Jun-ichi Kishikawa, Takayuki Kato, Jessica Anindita, Yoshifumi Nishikawa, Masatoshi Maeki, Manabu Tokeshi, Kota Tange, Yuta Nakai, Yu Sakurai, Takaharu Okada, Hidetaka Akita
Summary: RNA vaccines based on lipid nanoparticles with enhanced capability for inducing cellular immunity have shown promising results in both tumor models and infection models. In this study, an ionizable lipid with a vitamin E scaffold was used to develop RNA vaccines that successfully induced antigen-specific CD8(+) T cell responses and conferred protection against lethal infection. Additionally, conventional dendritic cells were found to be essential for the induction of CD8(+) T cell responses.
Review
Immunology
Luis Johnson Kangale, Didier Raoult, Pierre-Edouard Fournier, Prasad Abnave, Eric Ghigo
Summary: Planarians have emerged as a valuable model for studying innate immunity due to their broad spectrum bacterial resistance, shedding light on the origins of vertebrate immune mechanisms. Research focuses on antimicrobial resistance genes, signaling pathways, and immune cells in planarians.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sambit K. Nanda, Alan R. Prescott, Clara Figueras-Vadillo, Philip Cohen
Summary: The rapid formation and activation of the NLRP3 inflammasome is induced by co-stimulation with LPS and nigericin. IKK beta plays a crucial role in recruiting NLRP3 to the dispersed TGN, leading to the formation and activation of the NLRP3 inflammasome.
Article
Immunology
Anthony Bosco
Summary: Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Recent findings highlight novel aspects of the interferon response in sLRI pathogenesis and provide new directions for mechanistic studies and drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Eleonora Cimini, Chiara Agrati
Summary: New emerging viruses pose serious threats to public health and are a global concern. Monitoring the emergence and transmission of these viruses is crucial for public health authorities. γδ T cells, as part of the innate immune system, play a vital role in protecting the host from viral infections. They have the ability to directly combat a wide range of viruses and orchestrate the interaction between innate and acquired immunity.
Review
Immunology
Ying Li, Jiao Lv, Weikai Shi, Jia Feng, Mingxi Liu, Shenao Gan, Hongjin Wu, Weiwei Fan, Ming Shi
Summary: Inflammasomes are innate immune mechanisms associated with tumorigenesis and prognosis of cancers. They drive the production of inflammatory cytokines and recruit immune cells to tumor sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Anne Maria Thomas, Swapna P. P. Antony
Summary: The emergence of multidrug-resistant pathogens has created a global health crisis, leading to the urgent need for alternatives to antibiotics. Antimicrobial peptides, found in various marine organisms, offer a unique potential as they have broad-spectrum activity, low cytotoxicity, and high stability. This review aims to synthesize information on distinctive marine antimicrobial peptides discovered in the past decade and discuss their prospects.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Cell Biology
Hui Yang, Bruce Beutler, Duanwu Zhang
Summary: The spliceosome, while crucial for cell function, can also be implicated in diseases and serve as a target for cancer therapy. Research has shown connections between the spliceosome and immune signaling, leading to immune dysregulation. Furthermore, core spliceosome components have splicing-independent immune functions, adding to their functional diversity.
Review
Cell Biology
Yimeng Wang, Lifang Li, Jiaqi Li, Bin Zhao, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: m6A, the most prevalent RNA modification, plays a crucial role in physiological and pathological processes, particularly in the pathogenesis of immune-related diseases. It may serve as a promising epitranscriptomic target for preventing and treating autoimmune disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Jianyang Liu, Yan Huang, Ting Li, Zheng Jiang, Liuwang Zeng, Zhiping Hu
Summary: The Golgi apparatus plays a crucial role in cellular homeostasis and is linked to various diseases. Mutations in genes encoding Golgi resident proteins can lead to diseases, typically involving defects in membrane trafficking, protein mislocalization, and impaired glycosylation. Detection of Golgi resident proteins in human serum samples may serve as a diagnostic tool, while the central role of Golgi apparatus in membrane trafficking pathways presents potential targets for disease therapy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Christian Jetschni, Peter Goetz
Summary: This study aimed to establish and define the necessary structures to simulate the process of N-glycosylation in silico. The process of glycosylation in the Golgi structure was represented in an agent-based model with defined movement patterns and reaction rules.
FERMENTATION-BASEL
(2023)
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Wentao Zhang, Yanling Li, Shuyu Xin, Li Yang, Mingjuan Jiang, Yujie Xin, Yiwei Wang, Pengfei Cao, Senmiao Zhang, Yang Yang, Jianhong Lu
Summary: IFIT3 is an important protein induced by interferon, playing a role in antiviral innate immunity and regulating cellular biology. It has the potential to serve as a biomarker for disease diagnosis and therapy.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Ye Tao, Neil Gross, Xiaojiao Fan, Jianming Yang, Maikun Teng, Xu Li, Guojun Li, Yang Zhang, Zhigang Huang
Article
Oncology
Ye Tao, Erich M. Sturgis, Zhigang Huang, Ying Wang, Peng Wei, Jennifer Rui Wang, Qingyi Wei, Guojun Li
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Ye Tao, Erich M. Sturgis, Zhigang Huang, Yan Sun, Kristina R. Dahlstrom, Qingyi Wei, Guojun Li
INTERNATIONAL JOURNAL OF CANCER
(2018)
Review
Immunology
Tao Gong, Yanqing Yang, Tengchuan Jin, Wei Jiang, Rongbin Zhou
TRENDS IN IMMUNOLOGY
(2018)
Article
Immunology
Yanqing Yang, Xueting Lang, Song Sun, Chun Gao, Jianguo Hu, Shuqin Ding, Jing Li, Yuyun Li, Fengchao Wang, Tao Gong
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Tao Gong, Wei Jiang, Rongbin Zhou
TRENDS IN BIOCHEMICAL SCIENCES
(2018)
Review
Pharmacology & Pharmacy
Tiantian Tang, Tao Gong, Wei Jiang, Rongbin Zhou
TRENDS IN PHARMACOLOGICAL SCIENCES
(2018)
Article
Immunology
Lei Liu, Tao Gong, Wanyin Tao, Bolong Lin, Cong Li, Xuesen Zheng, Shu Zhu, Wei Jiang, Rongbin Zhou
Editorial Material
Immunology
Tao Gong, Rongbin Zhou
Article
Oncology
Ye Tao, Hailong Shen, Yujie Liu, Guojun Li, Zhigang Huang, Yehai Liu
Summary: The study revealed the significant role of IL-23R in laryngeal cancer progression, with high expression associated with poor prognosis. Additionally, IL-23R was found to facilitate cancer cell proliferation and cisplatin resistance through phosphorylating STAT3.
Article
Immunology
Yi Zhao, Yujie Liu, Fangzheng Yi, Jun Zhang, Zhaohui Xu, Yehai Liu, Ye Tao
Summary: Type 2 diabetes mellitus (T2DM) can impair nasal mucosa and lymphoid tissues, increasing the risk of olfactory dysfunction in COVID-19 patients. Studies on both patients and animal models suggest that T2DM weakens nasal immunity, emphasizing the importance of understanding the mechanisms for COVID-19 treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Tao Gong, Lei Liu, Wei Jiang, Rongbin Zhou
NATURE REVIEWS IMMUNOLOGY
(2020)
Article
Cell Biology
Ye Tao, Tianchang Tao, Neil Gross, Xuyun Peng, Ying Li, Zhigang Huang, Limei Liu, Guojun Li, Xiaohong Chen, Jianming Yang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)