Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis

(2020) Alisa Atkins et al.   eLife

Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage

(2019) Kelvin W. Pond et al.   PLoS Genetics

Dynamic Processing of Displacement Loops during Recombinational DNA Repair

(2019) Aurèle Piazza et al.   MOLECULAR CELL

SMC 5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability

(2019) Francesco Rossi et al.   EMBO REPORTS

Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites

(2018) Xiao P. Peng et al.   PLoS Genetics

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects

(2018) Anjana Srivatsan et al.   Nature Communications

The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative

(2018) Luis Aragón   Annual Review of Genetics

Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6

(2016) Marcelino Bermúdez-López et al.   GENES & DEVELOPMENT

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

(2016) Saskia N. van der Crabben et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability

(2016) Arianna Colosio et al.   NUCLEIC ACIDS RESEARCH

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates

(2016) Jaclyn N. Bonner et al.   Cell Reports

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

(2015) A. Jacome et al.   EMBO JOURNAL

Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication

(2015) Madhusoodanan Urulangodi et al.   GENES & DEVELOPMENT

Top3-Rmi1 DNA Single-Strand Decatenase Is Integral to the Formation and Resolution of Meiotic Recombination Intermediates

(2015) Hardeep Kaur et al.   MOLECULAR CELL

Pervasive and Essential Roles of the Top3-Rmi1 Decatenase Orchestrate Recombination and Facilitate Chromosome Segregation in Meiosis

(2015) Shangming Tang et al.   MOLECULAR CELL

Top3-Rmi1 Dissolve Rad51-Mediated D Loops by a Topoisomerase-Based Mechanism

(2015) Clare L. Fasching et al.   MOLECULAR CELL

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance

(2015) Demis Menolfi et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability

(2015) Stephanie A. Schalbetter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

(2014) V. Gonzalez-Huici et al.   EMBO JOURNAL

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance

(2014) Felicity Payne et al.   JOURNAL OF CLINICAL INVESTIGATION

Restriction of Replication Fork Regression Activities by a Conserved SMC Complex

(2014) Xiaoyu Xue et al.   MOLECULAR CELL

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

(2014) Nicholas A. Willis et al.   NATURE

The maintenance of chromosome structure: positioning and functioning of SMC complexes

(2014) Kristian Jeppsson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualization of recombination-mediated damage bypass by template switching

(2014) Michele Giannattasio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae

(2014) W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

(2013) Barnabas Szakal et al.   EMBO JOURNAL

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Mph1 and Mus81-Mms4 Prevent Aberrant Processing of Mitotic Recombination Intermediates

(2013) Gerard Mazón et al.   MOLECULAR CELL

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

(2013) Cindy Follonier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Smc5/6-Mms21 Prevents and Eliminates Inappropriate Recombination Intermediates in Meiosis

(2013) Martin Xaver et al.   PLoS Genetics

Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins in Saccharomyces cerevisiae

(2012) E. Cheng et al.   GENETICS

During Replication Stress, Non-Smc Element 5 (Nse5) Is Required for Smc5/6 Protein Complex Functionality at Stalled Forks

(2012) Denise E. Bustard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae

(2011) T. M. Ashton et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage

(2011) H. W. Mankouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX

(2010) Rachel K Szilard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription

(2009) Rodrigo Bermejo et al.   CELL

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast

(2009) A. L. Paek et al.   GENES & DEVELOPMENT

The Saccharomyces cerevisiae Esc2 and Smc5-6 Proteins Promote Sister Chromatid Junction-mediated Intra-S Repair

(2009) Julie Sollier et al.   MOLECULAR BIOLOGY OF THE CELL

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

Smc5/6: a link between DNA repair and unidirectional replication?

(2007) Johanne M. Murray et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY