Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites

Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6

(2016) Marcelino Bermúdez-López et al.   GENES & DEVELOPMENT

Mms21 SUMO Ligase Activity Promotes Nucleolar Function in Saccharomyces cerevisiae

(2016) D.-H. Kim et al.   GENETICS

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

(2016) Saskia N. van der Crabben et al.   JOURNAL OF CLINICAL INVESTIGATION

A new MCM modification cycle regulates DNA replication initiation

(2016) Lei Wei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A new MCM modification cycle regulates DNA replication initiation

(2016) Lei Wei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates

(2016) Jaclyn N. Bonner et al.   Cell Reports

Functions and regulation of the multitasking FANCM family of DNA motor proteins

(2015) Xiaoyu Xue et al.   GENES & DEVELOPMENT

Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases

(2015) Lisa E. Hang et al.   MOLECULAR CELL

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance

(2015) Demis Menolfi et al.   MOLECULAR CELL

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

(2015) Prabha Sarangi et al.   PLoS Genetics

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance

(2014) Felicity Payne et al.   JOURNAL OF CLINICAL INVESTIGATION

Restriction of Replication Fork Regression Activities by a Conserved SMC Complex

(2014) Xiaoyu Xue et al.   MOLECULAR CELL

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

(2014) Jeannine Diesch et al.   Cell and Bioscience

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

The nucleolus—guardian of cellular homeostasis and genome integrity

(2013) Ingrid Grummt   CHROMOSOMA

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

(2013) Limei Ju et al.   DNA REPAIR

DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of smc6 mutants

(2013) Yu-Hung Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells

(2013) Lina Marcela Gallego-Paez et al.   MOLECULAR BIOLOGY OF THE CELL

SUMOylation of the α-Kleisin Subunit of Cohesin Is Required for DNA Damage-Induced Cohesion

(2012) Alexandra McAleenan et al.   CURRENT BIOLOGY

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

(2012) Marta B Davidson et al.   EMBO JOURNAL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

During Replication Stress, Non-Smc Element 5 (Nse5) Is Required for Smc5/6 Protein Complex Functionality at Stalled Forks

(2012) Denise E. Bustard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin

(2012) Luz Irina A Calderón Villalobos et al.   Nature Chemical Biology

The Smc5-Smc6 Complex Regulates Recombination at Centromeric Regions and Affects Kinetochore Protein Sumoylation during Normal Growth

(2012) Vladimir Yong-Gonzales et al.   PLoS One

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

(2011) Takehiko Kobayashi   CELLULAR AND MOLECULAR LIFE SCIENCES

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

Systematic Reduction of Cohesin Differentially Affects Chromosome Segregation, Condensation, and DNA Repair

(2010) Jill M. Heidinger-Pauli et al.   CURRENT BIOLOGY

The Smc5/6 Complex and Esc2 Influence Multiple Replication-associated Recombination Processes in Saccharomyces cerevisiae

(2010) Koyi Choi et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX

(2010) Rachel K Szilard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

The STRUCTURAL MAINTENANCE OF CHROMOSOMES 5/6 Complex Promotes Sister Chromatid Alignment and Homologous Recombination after DNA Damage in Arabidopsis thaliana

(2009) K. Watanabe et al.   PLANT CELL

Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair

(2009) Yu-Hung Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smc5–Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications

(2008) Ji-Young Hwang et al.   DNA REPAIR

Cooperation of Sumoylated Chromosomal Proteins in rDNA Maintenance

(2008) Yoshimitsu Takahashi et al.   PLoS Genetics