miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

A novel pathway regulates social hierarchy via lncRNA AtLAS and postsynaptic synapsin IIb

(2020) Mei Ma et al.   CELL RESEARCH

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

(2020) Nipun Chopra et al.   MOLECULAR PSYCHIATRY

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo

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Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures

(2019) Vamshidhar R. Vangoor et al.   JOURNAL OF NEUROSCIENCE

Acute Disruption of the Dorsal Hippocampus Impairs the Encoding and Retrieval of Trace Fear Memories

(2019) Jacob H. Wilmot et al.   Frontiers in Behavioral Neuroscience

Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid

(2019) Benjamin W. Henderson et al.   Science Signaling

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(2019) Yann Humeau et al.   NATURE NEUROSCIENCE

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer’s Disease

(2018) Xiong Wang et al.   BIOLOGICAL PSYCHIATRY

FOXD3 inhibits SCN2A gene transcription in intractable epilepsy cell models

(2018) Jun Xiang et al.   EXPERIMENTAL NEUROLOGY

MicroRNA-26a/Death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson’s disease

(2018) Ying Su et al.   BIOLOGICAL PSYCHIATRY

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4

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miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala

(2017) Cecilia Mannironi et al.   MOLECULAR NEUROBIOLOGY

Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer’s Disease

(2017) Dan Liu et al.   MOLECULAR THERAPY

Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders

(2017) Alisa E. Shaw et al.   PHARMACOLOGY & THERAPEUTICS

MicroRNAs, miR-23a-3p and miR-151-3p, Are Regulated in Dentate Gyrus Neuropil following Induction of Long-Term Potentiation In Vivo

(2017) Brigid Ryan et al.   PLoS One

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease

(2017) Rached Alkallas et al.   Nature Communications

Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice

(2016) Dominic Landgraf et al.   BIOLOGICAL PSYCHIATRY

The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer

(2016) G Y He et al.   BRITISH JOURNAL OF CANCER

FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity

(2016) Raga Krishnakumar et al.   Cell Stem Cell

Novel microRNA revealed by systematic analysis of the microRNA transcriptome in dentate gyrus granule cells

(2016) Brigid Ryan et al.   NEUROSCIENCE LETTERS

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

(2015) Yunching Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Kinase-interacting substrate screening is a novel method to identify kinase substrates

(2015) Mutsuki Amano et al.   JOURNAL OF CELL BIOLOGY

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

(2015) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2015) Yanwen Guo et al.   NUCLEIC ACIDS RESEARCH

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miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement

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Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation

(2015) Brigid Ryan et al.   Frontiers in Molecular Neuroscience

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

(2014) Frank Jessen et al.   Alzheimers & Dementia

MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein

(2014) Chen-geng Liu et al.   BRAIN RESEARCH

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2

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miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression

(2014) Zhonghua Hu et al.   Nature Communications

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Recombinant AAV as a Platform for Translating the Therapeutic Potential of RNA Interference

(2013) Florie Borel et al.   MOLECULAR THERAPY

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice

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Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines

(2012) Peter Penzes et al.   Cytoskeleton

Melatonin Attenuates Scopolamine-Induced Memory/Synaptic Disorder by Rescuing EPACs/miR-124/Egr1 Pathway

(2012) Xiong Wang et al.   MOLECULAR NEUROBIOLOGY

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

(2012) Amy E. Pasquinelli   NATURE REVIEWS GENETICS

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

(2012) Thomas M. Wishart et al.   PLoS Genetics

microRNAs in neurons: manifold regulatory roles at the synapse

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(2011) Lukas Sommer   Pigment Cell & Melanoma Research

Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing

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Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter

(2010) Wang-Xia Wang et al.   ACTA NEUROPATHOLOGICA

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

Hippocampal long-term depression is required for the consolidation of spatial memory

(2010) Y. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

(2009) Hui Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation

(2009) Sourav Banerjee et al.   NEURON

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

Prevention of common neurodegenerative disorders in the elderly

(2008) Laura Fratiglioni et al.   EXPERIMENTAL GERONTOLOGY

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

(2008) R. Minkeviciene et al.   JOURNAL OF NEUROCHEMISTRY

Phosphoproteomic Analysis of Human Brain by Calcium Phosphate Precipitation and Mass Spectrometry

(2008) Qiangwei Xia et al.   JOURNAL OF PROTEOME RESEARCH

Activity-Dependent Synaptogenesis: Regulation by a CaM-Kinase Kinase/CaM-Kinase I/βPIX Signaling Complex

(2008) Takeo Saneyoshi et al.   NEURON

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

(2008) Zikai Zhou et al.   NEUROPHARMACOLOGY

Dissociations across the dorsal–ventral axis of CA3 and CA1 for encoding and retrieval of contextual and auditory-cued fear

(2007) Michael R. Hunsaker et al.   NEUROBIOLOGY OF LEARNING AND MEMORY