Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines

Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology

(2011) Odelia Y.N. Bongmba et al.   BRAIN RESEARCH

Neuronal specific βPix-b stimulates actin-dependent processes via the interaction between its PRD and WH1 domain of N-WASP

(2011) Joohyun Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity

(2011) Pedro J Chacon et al.   Molecular Neurodegeneration

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

(2011) Richard C Davis et al.   Molecular Neurodegeneration

Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition

(2011) M E Cahill et al.   MOLECULAR PSYCHIATRY

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology

(2011) Anthony J. Deo et al.   NEUROBIOLOGY OF DISEASE

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

(2011) Kea Joo Lee et al.   NEURON

Intersectin 1 contributes to phenotypes in vivo

(2011) Michael P. Hunter et al.   NEUROREPORT

High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: Brain overgrowth associated withHRASmutations as the likely cause of structural brain and spinal cord abnormalities

(2010) Karen W. Gripp et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

The Tiam1 PDZ Domain Couples to Syndecan1 and Promotes Cell–Matrix Adhesion

(2010) Tyson R. Shepherd et al.   JOURNAL OF MOLECULAR BIOLOGY

Physiological Activation of Synaptic Rac>PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome

(2010) L. Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons

(2010) Eunice Y. Yuen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epac2-mediated dendritic spine remodeling: Implications for disease

(2010) Peter Penzes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity

(2010) Jiaping Gu et al.   NATURE NEUROSCIENCE

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines

(2010) Nicholas A. Frost et al.   NEURON

ADDLs and the signaling web that leads to Alzheimer’s disease

(2010) Grant A. Krafft et al.   NEUROPHARMACOLOGY

Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth

(2010) Shahrzad Shirazi Fard et al.   PLoS One

The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin

(2010) K. Farid Ahmad et al.   PLoS One

Pak1 Phosphorylation Enhances Cortactin-N-WASP Interaction in Clathrin-Caveolin-Independent Endocytosis

(2010) Alexandre Grassart et al.   TRAFFIC

Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia

(2009) Peixiong Yuan et al.   JOURNAL OF AFFECTIVE DISORDERS

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

(2009) Sébastien Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

(2009) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

(2009) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons

(2009) Kazuya Kuramoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

(2009) Farida Korobova et al.   MOLECULAR BIOLOGY OF THE CELL

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

(2009) Kevin M Woolfrey et al.   NATURE NEUROSCIENCE

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

(2009) M. E. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade

(2009) M.-G. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology

(2009) T. McAvoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spine microdomains for postsynaptic signaling and plasticity

(2009) Thomas M. Newpher et al.   TRENDS IN CELL BIOLOGY

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON

The WASP and WAVE family proteins

(2009) Shusaku Kurisu et al.   GENOME BIOLOGY

Function of the N-terminus of zizimin1: autoinhibition and membrane targeting

(2008) Nahum Meller et al.   BIOCHEMICAL JOURNAL

Molecular profiles of schizophrenia in the CNS at different stages of illness

(2008) Sujatha Narayan et al.   BRAIN RESEARCH

Noonan, Costello and cardio–facio–cutaneous syndromes: dysregulation of the Ras–MAPK pathway

(2008) William E. Tidyman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

N-WASP and the Arp2/3 Complex Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses

(2008) Adam M. Wegner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Kalirin by Cdk5

(2008) X. Xin et al.   JOURNAL OF CELL SCIENCE

Constitutively Active Rap2 Transgenic Mice Display Fewer Dendritic Spines, Reduced Extracellular Signal-Regulated Kinase Signaling, Enhanced Long-Term Depression, and Impaired Spatial Learning and Fear Extinction

(2008) J. Ryu et al.   JOURNAL OF NEUROSCIENCE

SynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin

(2008) H. J. Carlisle et al.   JOURNAL OF NEUROSCIENCE

Organization of the Arp2/3 Complex in Hippocampal Spines

(2008) B. Racz et al.   JOURNAL OF NEUROSCIENCE

Kalirin-7 Is Required for Synaptic Structure and Function

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

The Pak1 Kinase: An Important Regulator of Neuronal Morphology and Function in the Developing Forebrain

(2008) Margareta Nikolić   MOLECULAR NEUROBIOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE

Activity-Dependent Synaptogenesis: Regulation by a CaM-Kinase Kinase/CaM-Kinase I/βPIX Signaling Complex

(2008) Takeo Saneyoshi et al.   NEURON

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

(2008) Naoki Honkura et al.   NEURON

The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine

(2008) C. D. Harvey et al.   SCIENCE

Convergent CaMK and RacGEF signals control dendritic structure and function

(2008) Peter Penzes et al.   TRENDS IN CELL BIOLOGY

Dendritic spine dynamics – a key role for kalirin-7

(2008) Peter Penzes et al.   TRENDS IN NEUROSCIENCES

Translational gene mapping of cognitive decline

(2006) Beth Wilmot et al.   NEUROBIOLOGY OF AGING