The next generation of approaches to investigate the link between synaptic plasticity and learning

High-throughput synapse-resolving two-photon fluorescence microendoscopy for deep-brain volumetric imaging in vivo

(2019) Guanghan Meng et al.   eLife

Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning

(2019) Gergely Farkas Turi et al.   NEURON

A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission

(2019) Qi Liu et al.   NEURON

Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics

(2019) Yoav Adam et al.   NATURE

A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice

(2018) Fangmiao Sun et al.   CELL

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

(2018) Miao Jing et al.   NATURE BIOTECHNOLOGY

The role of engram cells in the systems consolidation of memory

(2018) Susumu Tonegawa et al.   NATURE REVIEWS NEUROSCIENCE

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

(2018) Tommaso Patriarchi et al.   SCIENCE

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

(2018) Sami El-Boustani et al.   SCIENCE

Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo

(2018) Matthew Dunn et al.   Nature Communications

In vivo STED microscopy visualizes PSD95 sub-structures and morphological changes over several hours in the mouse visual cortex

(2018) Waja Wegner et al.   Scientific Reports

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

(2018) Thomas Pfeiffer et al.   eLife

Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction

(2018) Holger Haselmann et al.   NEURON

Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning

(2018) Wataru Kakegawa et al.   NEURON

Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency

(2018) Kalina T Haas et al.   eLife

Bioorthogonal Click Chemistry Enables Site-specific Fluorescence Labeling of Functional NMDA Receptors for Super-Resolution Imaging

(2018) Franziska Neubert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Linking Nanoscale Dynamics of AMPA Receptor Organization to Plasticity of Excitatory Synapses and Learning

(2018) Daniel Choquet   JOURNAL OF NEUROSCIENCE

Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR

(2018) Jonathan S. Marvin et al.   NATURE METHODS

Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze

(2018) Haibing Xu et al.   NEURON

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

(2018) Ankit Awasthi et al.   SCIENCE

Neuronal competition: microcircuit mechanisms define the sparsity of the engram

(2018) Priyanka Rao-Ruiz et al.   CURRENT OPINION IN NEUROBIOLOGY

Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP

(2017) Dick Wu et al.   NATURE

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

(2017) A. C. Penn et al.   NATURE

Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

(2017) Weijian Zong et al.   NATURE METHODS

Dendritic spines: Morphological building blocks of memory

(2017) Menahem Segal   NEUROBIOLOGY OF LEARNING AND MEMORY

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor

(2017) Hideji Murakoshi et al.   NEURON

Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage

(2017) Tom Rossetti et al.   NEURON

A Brief History of Long-Term Potentiation

(2017) Roger A. Nicoll   NEURON

Behavioral time scale synaptic plasticity underlies CA1 place fields

(2017) Katie C. Bittner et al.   SCIENCE

Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist

(2017) David M. Barber et al.   Chemical Science

Functional mapping of brain synapses by the enriching activity-marker SynaptoZip

(2017) Mattia Ferro et al.   Nature Communications

Activity-dependent expression of Channelrhodopsin at neuronal synapses

(2017) Francesco Gobbo et al.   Nature Communications

Chemical labelling for visualizing native AMPA receptors in live neurons

(2017) Sho Wakayama et al.   Nature Communications

Gamma Oscillations in Rat Hippocampal Subregions Dentate Gyrus, CA3, CA1, and Subiculum Underlie Associative Memory Encoding

(2017) John B. Trimper et al.   Cell Reports

Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta)

(2017) John Lisman   Molecular Brain

Optocontrol of glutamate receptor activity by single side-chain photoisomerization

(2017) Viktoria Klippenstein et al.   eLife

A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

(2016) Ai-Hui Tang et al.   NATURE

Optical inactivation of synaptic AMPA receptors erases fear memory

(2016) Kiwamu Takemoto et al.   NATURE BIOTECHNOLOGY

Genetically encoded indicators of neuronal activity

(2016) Michael Z Lin et al.   NATURE NEUROSCIENCE

CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory

(2016) Joongkyu Park et al.   NEURON

Cell-specific synaptic plasticity induced by network oscillations

(2016) Shota Zarnadze et al.   eLife

Cellular plasticity induced by anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis antibodies

(2015) Xiaoyu Peng et al.   ANNALS OF NEUROLOGY

Theta-burst LTP

(2015) John Larson et al.   BRAIN RESEARCH

Labelling and optical erasure of synaptic memory traces in the motor cortex

(2015) Akiko Hayashi-Takagi et al.   NATURE

Visualization of NMDA receptor–dependent AMPA receptor synaptic plasticity in vivo

(2015) Yong Zhang et al.   NATURE NEUROSCIENCE

Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

(2015) Katie C Bittner et al.   NATURE NEUROSCIENCE

Distinct Eligibility Traces for LTP and LTD in Cortical Synapses

(2015) Kaiwen He et al.   NEURON

Labeling of active neural circuits in vivo with designed calcium integrators

(2015) B. F. Fosque et al.   SCIENCE

Engram cells retain memory under retrograde amnesia

(2015) T. J. Ryan et al.   SCIENCE

Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses

(2014) J. P. Dupuis et al.   EMBO JOURNAL

Structural Plasticity within the Barrel Cortex during Initial Phases of Whisker-Dependent Learning

(2014) S. J. Kuhlman et al.   JOURNAL OF NEUROSCIENCE

Engineering a memory with LTD and LTP

(2014) Sadegh Nabavi et al.   NATURE

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

Target-Specific Vulnerability of Excitatory Synapses Leads to Deficits in Associative Memory in a Model of Intellectual Disorder

(2013) X. Houbaert et al.   JOURNAL OF NEUROSCIENCE

Super-Resolution Imaging Reveals That AMPA Receptors Inside Synapses Are Dynamically Organized in Nanodomains Regulated by PSD95

(2013) D. Nair et al.   JOURNAL OF NEUROSCIENCE

Fear Extinction Induces mGluR5-Mediated Synaptic and Intrinsic Plasticity in Infralimbic Neurons

(2013) M. T. Sepulveda-Orengo et al.   JOURNAL OF NEUROSCIENCE

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

LTP Requires a Unique Postsynaptic SNARE Fusion Machinery

(2013) Sandra Jurado et al.   NEURON

Dynamic Reconfiguration of Hippocampal Interneuron Circuits during Spatial Learning

(2013) David Dupret et al.   NEURON

Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI)

(2013) John Y. Lin et al.   NEURON

The Dynamic Synapse

(2013) Daniel Choquet et al.   NEURON

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

(2013) T. Takeuchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain

(2013) P. C. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Awake Hippocampal Sharp-Wave Ripples Support Spatial Memory

(2012) S. P. Jadhav et al.   SCIENCE

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

(2012) C. Luscher et al.   Cold Spring Harbor Perspectives in Biology

Functional mapping of single spines in cortical neurons in vivo

(2011) Xiaowei Chen et al.   NATURE

The reorganization and reactivation of hippocampal maps predict spatial memory performance

(2010) David Dupret et al.   NATURE NEUROSCIENCE

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure

(2010) R. L. Clem et al.   SCIENCE

Molecular Circuitry of Endocytosis at Nerve Terminals

(2009) Jeremy Dittman et al.   Annual Review of Cell and Developmental Biology

Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II  in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

(2009) Y. Yamagata et al.   JOURNAL OF NEUROSCIENCE

Activation of CaMKII in single dendritic spines during long-term potentiation

(2009) Seok-Jin R. Lee et al.   NATURE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Fluorescent False Neurotransmitters Visualize Dopamine Release from Individual Presynaptic Terminals

(2009) N. G. Gubernator et al.   SCIENCE

Selective Erasure of a Fear Memory

(2009) J.-H. Han et al.   SCIENCE

Balancing Structure and Function at Hippocampal Dendritic Spines

(2008) Jennifer N Bourne et al.   Annual Review of Neuroscience

Experience leaves a lasting structural trace in cortical circuits

(2008) Sonja B. Hofer et al.   NATURE

Live-cell imaging of dendritic spines by STED microscopy

(2008) U. V. Nagerl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission

(2008) M. Heine et al.   SCIENCE