MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

University fights restrictive law on fetal tissue research

(2019) Meredith Wadman   SCIENCE

A new step towards targeting tau

(2019) Jean-Christophe Corvol et al.   LANCET NEUROLOGY

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial

(2019) Adam L Boxer et al.   LANCET NEUROLOGY

Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy

(2019) Nicole M. Maphis et al.   npj Vaccines

Novel MicroRNA-455-3p and its protective effects against abnormal APP processing and amyloid beta toxicity in Alzheimer's disease

(2019) Subodh Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Over-expression of miR-34a induces rapid cognitive impairment and Alzheimer’s disease-like pathology

(2019) S. Sarkar et al.   BRAIN RESEARCH

MicroRNA-298 represses hepatocellular carcinoma progression by inhibiting CTNND1-mediated Wnt/β-catenin signaling

(2018) Ningjia Cao et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-15b Reduces Amyloid-β Accumulation in SH-SY5Y Cell Line through Targeting NF-κB signaling and BACE1

(2018) Juan Li et al.   BIOSCIENCE REPORTS

MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls

(2018) Peter T. Nelson et al.   BRAIN RESEARCH

MiR-298 Exacerbates Ischemia/Reperfusion Injury Following Ischemic Stroke by Targeting Act1

(2018) Hongxue Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

(2018) Xiangyou Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures

(2018) Javier G. Villamil-Ortiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Circulating miRNAs as Potential Biomarkers in Alzheimer's Disease

(2018) Daniela Galimberti et al.   JOURNAL OF ALZHEIMERS DISEASE

MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation

(2018) Bing-Lin Zhu et al.   BRAIN

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

(2018) Justin M. Long et al.   MOLECULAR PSYCHIATRY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders

(2017) Debomoy K. Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid precursor protein in pancreatic islets

(2017) Joshua A Kulas et al.   JOURNAL OF ENDOCRINOLOGY

Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy

(2017) Zihui Zheng et al.   PLANT PHYSIOLOGY

Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity

(2017) Uriya Bekenstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs-Based Inter-Domain Communication between the Host and Members of the Gut Microbiome

(2017) Maggie R. Williams et al.   Frontiers in Microbiology

Neuronal-expressed microRNA-targeted pseudogenes compete with coding genes in the human brain

(2017) S Barbash et al.   Translational Psychiatry

Differential Incorporation of Tau Isoforms in Alzheimer's Disease

(2017) Marisol Espinoza et al.   JOURNAL OF ALZHEIMERS DISEASE

MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study

(2017) Peter T. Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Both absolute and relative quantification of urinary mRNA are useful for non-invasive diagnosis of acute kidney allograft rejection

(2017) Jung-Woo Seo et al.   PLoS One

miR-186 in Alzheimer's disease: a big hope for a small RNA?

(2016) Saoussen Ben Halima et al.   JOURNAL OF NEUROCHEMISTRY

miR-186 is decreased in aged brain and suppresses BACE1 expression

(2016) Jaekwang Kim et al.   JOURNAL OF NEUROCHEMISTRY

Pairing beyond the Seed Supports MicroRNA Targeting Specificity

(2016) James P. Broughton et al.   MOLECULAR CELL

Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector

(2016) Sourav R Choudhury et al.   MOLECULAR THERAPY

MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy

(2016) Naemeh Pourshafie et al.   MOLECULAR THERAPY

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells

(2016) B Cardinali et al.   Cell Death & Disease

MicroRNA-135b has a neuroprotective role via targeting of β-site APP-cleaving enzyme 1

(2016) Yi Zhang et al.   Experimental and Therapeutic Medicine

Expression levels of JNK associated with polymorphic lactotransferrin haplotypes in human nasopharyngeal carcinoma

(2016) Gengqiu Luo et al.   Oncology Letters

MicroRNA-298 inhibits malignant phenotypes of epithelial ovarian cancer by regulating the expression of EZH2

(2016) Fenmei Zhou et al.   Oncology Letters

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

(2015) Andrew J. Saykin et al.   Alzheimers & Dementia

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Biochemical and Neuroimaging Studies in Subjective Cognitive Decline: Progress and Perspectives

(2015) Yu Sun et al.   CNS Neuroscience & Therapeutics

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms

(2015) Virgil Muresan et al.   EXPERIMENTAL CELL RESEARCH

Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept

(2015) Bo Halle et al.   JOURNAL OF NEURO-ONCOLOGY

Alzheimer antibody drugs show questionable potential

(2015) Sara Reardon   NATURE REVIEWS DRUG DISCOVERY

miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

(2015) Michael J. Moore et al.   Nature Communications

Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

(2015) Anna-Mariya Kirova et al.   Biomed Research International

Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment

(2015) Rebecca B. Weinberg et al.   Frontiers in Neuroscience

Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease

(2015) Sepideh Parsi et al.   Molecular Therapy-Nucleic Acids

Lessons from a BACE1 inhibitor trial: Off-site but not off base

(2014) Debomoy K. Lahiri et al.   Alzheimers & Dementia

MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein

(2014) Chen-geng Liu et al.   BRAIN RESEARCH

The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1

(2014) Patty Kandalepas et al.   Current Alzheimer Research

Liposomal delivery of nucleic acid-based anticancer therapeutics: BP-100-1.01

(2014) Ana Tari Ashizawa et al.   Expert Opinion on Drug Delivery

MicroRNA-384 regulates both amyloid precursor protein and β-secretase expression and is a potential biomarker for Alzheimer’s disease

(2014) CHEN-GENG LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Unambiguous Identification of miRNA:Target Site Interactions by Different Types of Ligation Reactions

(2014) Stefanie Grosswendt et al.   MOLECULAR CELL

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

(2014) CHEN-GENG LIU et al.   Molecular Medicine Reports

Identification and consequences of miRNA–target interactions — beyond repression of gene expression

(2014) Jean Hausser et al.   NATURE REVIEWS GENETICS

Human primary mixed brain cultures: preparation, differentiation, characterization and application to neuroscience research

(2014) Balmiki Ray et al.   Molecular Brain

Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells

(2014) Wang-Xia Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

MicroRNA-346 stimulates APP expression by blockading an iron response element in the APP 5'-UTR: A novel therapeutic target for Alzheimer's disease (AD)

(2013) Debomoy Lahiri et al.   Alzheimers & Dementia

Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel

(2013) Hao Wu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

(2013) Aleksandra Helwak et al.   CELL

MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects

(2013) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

(2013) K Nho et al.   MOLECULAR PSYCHIATRY

MicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1

(2012) Hong-Can Zhu et al.   BRAIN RESEARCH BULLETIN

Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders

(2012) Justin M. Long et al.   EXPERIMENTAL NEUROLOGY

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients

(2012) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Proteasein Vivo

(2012) Lujia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

(2012) Gabriel B. Loeb et al.   MOLECULAR CELL

MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2

(2011) Chunlian Liang et al.   BRAIN RESEARCH

Current Drug Targets for Modulating Alzheimer's Amyloid Precursor Protein: Role of Specific Micro-RNA Species

(2011) J.M. Long et al.   CURRENT MEDICINAL CHEMISTRY

miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression

(2011) Jaekwang Kim et al.   EXPERIMENTAL NEUROLOGY

Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-β

(2011) Nicole Schonrock et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease

(2011) Giuseppe Astarita et al.   PLoS One

MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

(2010) Justin M. Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-101 Regulates Amyloid Precursor Protein Expression in Hippocampal Neurons

(2010) Elisa Vilardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs

(2010) Pascal Smith et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice

(2010) Wei Liu et al.   NEUROBIOLOGY OF AGING

Genome-wide association study of CSF biomarkers A 1-42, t-tau, and p-tau181p in the ADNI cohort

(2010) S. Kim et al.   NEUROLOGY

Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression

(2010) A. Git et al.   RNA

Molecular insights into  -galactoside  2,6-sialyltransferase secretion in vivo

(2009) S. Kitazume et al.   GLYCOBIOLOGY

The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

(2009) J. Vogel et al.   NEUROPHARMACOLOGY

Convergent Functional Genomics: what we have learned and can learn about genes, pathways and mechanisms

(2009) Alexander B Niculescu et al.   NEUROPSYCHOPHARMACOLOGY

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

DIANA-microT web server: elucidating microRNA functions through target prediction

(2009) M. Maragkakis et al.   NUCLEIC ACIDS RESEARCH

RISC-target interaction: Cleavage and translational suppression

(2008) A VANDENBERG et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1

(2008) Vincent Boissonneault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA