Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer

Small Molecule Inhibitors Targeting the Key Proteins in DNA Damage Response for Cancer Therapy

(2020) Lulu Li et al.   CURRENT MEDICINAL CHEMISTRY

APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF

(2020) Yoo-Duk Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion

(2020) Rita Manguinhas et al.   Antioxidants

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

(2019) Barbara Frossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors.

(2019) Safi Shahda et al.   JOURNAL OF CLINICAL ONCOLOGY

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

(2019) Yinyin Li et al.   Cell Metabolism

Enhanced activity of variant DNA polymerase β (D160G) contributes to cisplatin therapy by impeding the efficiency of NER

(2019) Meina Wang et al.   MOLECULAR CANCER RESEARCH

Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer

(2019) Melissa L. Fishel et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer

(2019) Xiao Lu et al.   ONCOGENE

Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway

(2019) Marta Codrich et al.   DNA REPAIR

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

APE1: A skilled nucleic acid surgeon

(2018) Amy M. Whitaker et al.   DNA REPAIR

The regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer

(2018) Xiao Yang et al.   Cancer Medicine

Differential expression of APE1 in hepatocellular carcinoma and the effects on proliferation and apoptosis of cancer cells

(2018) Zhipeng Sun et al.   BioScience Trends

APE1 stimulates EGFR-TKI resistance by activating Akt signaling through a redox-dependent mechanism in lung adenocarcinoma

(2018) Guo-Shou Lu et al.   Cell Death & Disease

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

(2017) Lingfeng He et al.   Molecular Oncology

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

(2017) Giulia Antoniali et al.   Nature Communications

An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes

(2017) Canrong Zhong et al.   PLoS Pathogens

APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target

(2016) Xuemei Wen et al.   Cancer Biomarkers

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Regulated cell death and adaptive stress responses

(2016) Lorenzo Galluzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Scientific Advances in Lung Cancer 2015

(2016) Anne S. Tsao et al.   Journal of Thoracic Oncology

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Targeted therapies for treatment of non-small cell lung cancer-Recent advances and future perspectives

(2015) Joan Minguet et al.   INTERNATIONAL JOURNAL OF CANCER

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

(2015) Mattia Poletto et al.   MOLECULAR CARCINOGENESIS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Capturing snapshots of APE1 processing DNA damage

(2015) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Capturing snapshots of APE1 processing DNA damage

(2015) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Association of DNA base excision repair genes (OGG1,APE1andXRCC1) polymorphisms with outcome to platinum-based chemotherapy in advanced nonsmall-cell lung cancer patients

(2014) Yu Peng et al.   INTERNATIONAL JOURNAL OF CANCER

Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer

(2013) Tarek M. A. Abdel-Fatah et al.   BREAST CANCER RESEARCH AND TREATMENT

Human Apurinic/Apyrimidinic Endonuclease siRNA Inhibits the Angiogenesis Induced by X-Ray Irradiation in Lung Cancer Cells

(2013) Xianqing Gu et al.   International Journal of Medical Sciences

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

(2012) Rebeka Sultana et al.   INTERNATIONAL JOURNAL OF CANCER

Two Novel Determinants of Etoposide Resistance in Small Cell Lung Cancer

(2011) M. H. Lawson et al.   CANCER RESEARCH

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma

(2011) Michael S. Bobola et al.   INTERNATIONAL JOURNAL OF CANCER

First-Line Systemic Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer: A Systematic Review

(2010) John Goffin et al.   Journal of Thoracic Oncology

Knock down of the dual functional protein apurinic /apyrimidinic endonuclease 1 enhances the killing effect of hematoporphrphyrin derivative-mediated photodynamic therapy on non-small cell lung cancer cells in vitro and in a xenograft model

(2009) Zhen-Zhou Yang et al.   CANCER SCIENCE

APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells

(2009) Dong Wang et al.   LUNG CANCER

Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein

(2008) Kishor K. Bhakat et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA Damage and Repair Capacity in Patients With Lung Cancer: Prediction of Multiple Primary Tumors

(2008) Irene Orlow et al.   JOURNAL OF CLINICAL ONCOLOGY