Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

(2011) M Z Mohammed et al.   BRITISH JOURNAL OF CANCER

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

(2011) Timothy A. Yap et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

(2011) M. L. Fishel et al.   MOLECULAR CANCER THERAPEUTICS

The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

(2011) Thomas Helleday   Molecular Oncology

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

(2011) Wenjian Ma et al.   PLoS Genetics

A review of PARP inhibitors: from bench to bedside

(2010) C. Underhill et al.   ANNALS OF ONCOLOGY

Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer

(2010) Rachel Abbotts et al.   CANCER TREATMENT REVIEWS

Small molecule inhibitors of DNA repair nuclease activities of APE1

(2010) David M. Wilson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Poly (ADP-Ribose) Polymerase as a Novel Therapeutic Target in Cancer

(2010) C. M. Annunziata et al.   CLINICAL CANCER RESEARCH

PARP inhibition: targeting the Achillesʼ heel of DNA repair to treat germline and sporadic ovarian cancers

(2010) Craig P Carden et al.   CURRENT OPINION IN ONCOLOGY

How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation

(2010) Aswin Mangerich et al.   INTERNATIONAL JOURNAL OF CANCER

Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

(2010) A. Bapat et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Essential Role of DNA Base Excision Repair on Survival in an Acidic Tumor Microenvironment

(2009) Y. Seo et al.   CANCER RESEARCH

DNA double-strand breaks: Their production, recognition, and repair in eukaryotes

(2009) Takeo Ohnishi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1

(2009) Anton Simeonov et al.   PLoS One

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY

Pharmacophore Guided Discovery of Small-Molecule Human Apurinic/Apyrimidinic Endonuclease 1 Inhibitors

(2008) Zahrah Zawahir et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Abasic Endonuclease Activity of Human Ape1 on Alternative Substrates, as Well as Effects of ATP and Sequence Context on AP Site Incision

(2008) Brian R. Berquist et al.   JOURNAL OF MOLECULAR BIOLOGY