Phillygenin protects against osteoarthritis by repressing inflammation via PI3K/Akt/NF-κB signaling: In vitro and vivo studies

The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

(2020) K. Sun et al.   OSTEOARTHRITIS AND CARTILAGE

Chondroprotective Effect of Cynaroside in IL-1β-Induced Primary Rat Chondrocytes and Organ Explants via NF-κB and MAPK Signaling Inhibition

(2020) Seul Ah. Lee et al.   Oxidative Medicine and Cellular Longevity

Rat Chondrocyte Inflammation and Osteoarthritis Are Ameliorated by Madecassoside

(2020) Safwat Adel Abdo Moqbel et al.   Oxidative Medicine and Cellular Longevity

Phillygenin, a MELK Inhibitor, Inhibits Cell Survival and Epithelial–Mesenchymal Transition in Pancreatic Cancer Cells

(2020) Hongchun Li et al.   OncoTargets and Therapy

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats

(2020) Hui Gao et al.   Drug Design Development and Therapy

Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis

(2020) Hyun Sik Na et al.   Frontiers in Immunology

Phillygenin Exerts In Vitro and In Vivo Antitumor Effects in Drug-Resistant Human Esophageal Cancer Cells by Inducing Mitochondrial-Mediated Apoptosis, ROS Generation, and Inhibition of the Nuclear Factor kappa B NF-κB Signalling Pathway

(2019) Jiantao He et al.   MEDICAL SCIENCE MONITOR

A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

(2019) Yuanyuan Shi et al.   Nature Communications

Lixisenatide attenuates advanced glycation end products (AGEs)-induced degradation of extracellular matrix in human primary chondrocytes

(2019) Xin Li et al.   Artificial Cells Nanomedicine and Biotechnology

Phillygenin, a lignan compound, inhibits hypertension by reducing PLCβ3-dependent Ca2+ oscillation

(2019) Wenjuan Liu et al.   Journal of Functional Foods

Downregulating Akt/NF-κB signaling and its antioxidant activity with Loureirin A for alleviating the progression of osteoarthritis: In vitro and vivo studies

(2019) Sun-Li Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway

(2019) Naihua Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of IkappaBzeta

(2018) Moon-Chang Choi et al.   Arthritis & Rheumatology

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies

(2018) Zhi-Chao Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis

(2018) Yasutaka Murahashi et al.   Scientific Reports

MicroRNA-145 attenuates TNF-α-driven cartilage matrix degradation in osteoarthritis via direct suppression of MKK4

(2017) Guoli Hu et al.   Cell Death & Disease

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes

(2014) Christian Stratz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Complexity of Human Walking: A Knee Osteoarthritis Study

(2014) Margarita Kotti et al.   PLoS One

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Phenolic Antioxidants Isolated from the Flowers of Osmanthus fragrans

(2012) Chien-Ya Hung et al.   MOLECULES

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

Lignans from the Fruits ofForsythia suspensa(Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress

(2008) Min-Jung CHANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Anti-inflammatory activity of phylligenin, a lignan from the fruits of Forsythia koreana, and its cellular mechanism of action

(2008) Hyun Lim et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY

Osteoarthritis and nitric oxide

(2008) Steven B. Abramson   OSTEOARTHRITIS AND CARTILAGE

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE