A nexus of intrinsic dynamics underlies translocase priming

Trigger factor is a bona fide secretory pathway chaperone that interacts with SecB and the translocase

(2020) Jozefien De Geyter et al.   EMBO REPORTS

Molecular movie of nucleotide binding to a motor protein

(2020) Ana-Nicoleta Bondar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Graphs of dynamic H-bond networks: from model proteins to protein complexes in cell signaling

(2020) Michalis Lazaratos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

(2019) Robin A Corey et al.   eLife

Genetic Analysis of Protein Translocation

(2019) Thomas J. Silhavy et al.   PROTEIN JOURNAL

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

(2019) Seongmin Jang et al.   GENES & DEVELOPMENT

Protein translocation by the SecA ATPase occurs by a power‐stroke mechanism

(2019) Marco A Catipovic et al.   EMBO JOURNAL

Using Graphs of Dynamic Hydrogen-Bond Networks To Dissect Conformational Coupling in a Protein Motor

(2019) Konstantina Karathanou et al.   Journal of Chemical Information and Modeling

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

(2019) Marijn de Boer et al.   eLife

Simple mechanics of protein machines

(2019) Holger Flechsig et al.   Journal of the Royal Society Interface

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

(2019) Glenn R. Masson et al.   NATURE METHODS

Structure of the substrate-engaged SecA-SecY protein translocation machine

(2019) Chengying Ma et al.   Nature Communications

ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium

(2019) Giorgos Gouridis et al.   Cell Reports

HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

(2019) Zainab Ahdash et al.   eLife

ConSurf‐DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins

(2019) Adi Ben Chorin et al.   PROTEIN SCIENCE

Intrinsic dynamics is evolutionarily optimized to enable allosteric behavior

(2019) Yan Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Conservation of intrinsic dynamics in proteins — what have computational models taught us?

(2018) Sandhya P Tiwari et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dynamic Water Hydrogen-Bond Networks at the Interface of a Lipid Membrane Containing Palmitoyl-Oleoyl Phosphatidylglycerol

(2018) Konstantina Karathanou et al.   JOURNAL OF MEMBRANE BIOLOGY

Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions

(2018) Cesar A. Ramirez-Sarmiento et al.   METHODS

Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study

(2018) Björn Hellenkamp et al.   NATURE METHODS

The Preprotein Binding Domain of SecA Displays Intrinsic Rotational Dynamics

(2018) Niels Vandenberk et al.   STRUCTURE

Preprotein mature domains contain translocase targeting signals that are essential for secretion

(2017) Katerina E. Chatzi et al.   JOURNAL OF CELL BIOLOGY

The chaperone toolbox at the single-molecule level: From clamping to confining

(2017) Mario J. Avellaneda et al.   PROTEIN SCIENCE

Protein export through the bacterial Sec pathway

(2016) Alexandra Tsirigotaki et al.   NATURE REVIEWS MICROBIOLOGY

Förster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulers

(2016) Evelyn Ploetz et al.   Scientific Reports

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

(2016) William John Allen et al.   eLife

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS)

(2015) O. Vadas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Keep on Moving: Discovering and Perturbing the Conformational Dynamics of Enzymes

(2014) Gira Bhabha et al.   ACCOUNTS OF CHEMICAL RESEARCH

RNA Helicase Proteins as Chaperones and Remodelers

(2014) Inga Jarmoskaite et al.   Annual Review of Biochemistry

Analysis of SecA Dimerization in Solution

(2014) Andy J. Wowor et al.   BIOCHEMISTRY

Conformational dynamics in substrate-binding domains influences transport in the ABC importer GlnPQ

(2014) Giorgos Gouridis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein dynamics and motions in relation to their functions: several case studies and the underlying mechanisms

(2013) Li-Quan Yang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Quaternary Dynamics of the SecA Motor Drive Translocase Catalysis

(2013) Giorgos Gouridis et al.   MOLECULAR CELL

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

(2013) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimizing Back Exchange in the Hydrogen Exchange-Mass Spectrometry Experiment

(2012) Benjamin T. Walters et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Protein hydrogen exchange: Testing current models

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Energetics of SecA Dimerization

(2011) Andy J. Wowor et al.   JOURNAL OF MOLECULAR BIOLOGY

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pre-existing soft modes of motion uniquely defined by native contact topology facilitate ligand binding to proteins

(2011) Lidio Meireles et al.   PROTEIN SCIENCE

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

SecA: a tale of two protomers

(2010) Marios Frantzeskos Sardis et al.   MOLECULAR MICROBIOLOGY

Folding and binding cascades: Dynamic landscapes and population shifts

(2010) Sandeep Kumar et al.   PROTEIN SCIENCE

Signal peptides are allosteric activators of the protein translocase

(2009) Giorgos Gouridis et al.   NATURE

Mapping polypeptide interactions of the SecA ATPase during translocation

(2009) B. W. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Assembly of the translocase motor onto the preprotein-conducting channel

(2008) Spyridoula Karamanou et al.   MOLECULAR MICROBIOLOGY

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE