Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

Unlocking the Bacterial SecY Translocon

(2016) Robin A. Corey et al.   STRUCTURE

Channel crossing: how are proteins shipped across the bacterial plasma membrane?

(2015) Ian Collinson et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

A “Push and Slide” Mechanism Allows Sequence-Insensitive Translocation of Secretory Proteins by the SecA ATPase

(2014) Benedikt W. Bauer et al.   CELL

Lipid14: The Amber Lipid Force Field

(2014) Callum J. Dickson et al.   Journal of Chemical Theory and Computation

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies

(2014) Amit Sharma et al.   NUCLEIC ACIDS RESEARCH

Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG–SecDF–YajC–YidC

(2014) Ryan J. Schulze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the SecY channel during initiation of protein translocation

(2013) Eunyong Park et al.   NATURE

Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species

(2013) C. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dynamic action of SecA during the initiation of protein translocation

(2012) Vicki A. M. Gold et al.   BIOCHEMICAL JOURNAL

Toward a Detailed Description of the Pathways of Allosteric Communication in the GroEL Chaperonin through Atomistic Simulation

(2012) Thomas J. Piggot et al.   BIOCHEMISTRY

Position-dependent Effects of Polylysine on Sec Protein Transport

(2012) Fu-Cheng Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex

(2012) Sarah Whitehouse et al.   JOURNAL OF CELL BIOLOGY

Structure of the SecY Complex Unlocked by a Preprotein Mimic

(2012) Dilem Hizlan et al.   Cell Reports

The Oligomeric State and Arrangement of the Active Bacterial Translocon

(2010) Karine Deville et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

(2010) Maarten G. Wolf et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Lateral Gate of SecYEG Opens during Protein Translocation

(2009) David J. F. du Plessis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

United Atom Lipid Parameters for Combination with the Optimized Potentials for Liquid Simulations All-Atom Force Field

(2009) Jakob P. Ulmschneider et al.   Journal of Chemical Theory and Computation

Charged Amino Acids in a Preprotein Inhibit SecA-Dependent Protein Translocation

(2009) Nico Nouwen et al.   JOURNAL OF MOLECULAR BIOLOGY

Motif III in Superfamily 2 “Helicases” Helps Convert the Binding Energy of ATP into a High-Affinity RNA Binding Site in the Yeast DEAD-Box Protein Ded1

(2009) Josette Banroques et al.   JOURNAL OF MOLECULAR BIOLOGY

Bacterial Sec Protein Transport Is Rate-limited by Precursor Length: A Single Turnover Study

(2009) Fu-Cheng Liang et al.   MOLECULAR BIOLOGY OF THE CELL

Signal peptides are allosteric activators of the protein translocase

(2009) Giorgos Gouridis et al.   NATURE

Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding

(2009) Takahide Kon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Energy transduction in protein transport and the ATP hydrolytic cycle of SecA

(2009) A. Robson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping polypeptide interactions of the SecA ATPase during translocation

(2009) B. W. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Antibiotics and a Proto-Oncogene Homolog on Destruction of Protein Translocator SecY

(2009) J. van Stelten et al.   SCIENCE

A role for the two-helix finger of the SecA ATPase in protein translocation

(2008) Karl J. Erlandson et al.   NATURE

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE