- Home
- Publications
- Publication Search
- Publication Details
Title
Evolving cryo-EM structural approaches for GPCR drug discovery
Authors
Keywords
GPCR, cryo-EM, drug discovery, patent free, method development
Journal
STRUCTURE
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-05-05
DOI
10.1016/j.str.2021.04.008
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors
- (2020) Shanshan Ma et al. MOLECULAR CELL
- Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
- (2020) Yi-Lynn Liang et al. MOLECULAR CELL
- Activation of the GLP-1 receptor by a non-peptidic agonist
- (2020) Peishen Zhao et al. NATURE
- Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
- (2020) Rulue Chang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural basis of Gs and Gi recognition by the human glucagon receptor
- (2020) Anna Qiao et al. SCIENCE
- Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis
- (2020) Mengyu Wu et al. BIOPHYSICAL JOURNAL
- Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
- (2020) Kuglae Kim et al. CELL
- Cryo-electron microscopy analysis of small membrane proteins
- (2020) Rie Nygaard et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
- (2020) Xin Zhang et al. MOLECULAR CELL
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- Structure and dynamics of the active Gs-coupled human secretin receptor
- (2020) Maoqing Dong et al. Nature Communications
- Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy
- (2020) Jia Duan et al. Nature Communications
- Structural basis for activation of the growth hormone-releasing hormone receptor
- (2020) Fulai Zhou et al. Nature Communications
- A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor
- (2020) Wen Sun et al. CELL RESEARCH
- GPCRdb in 2021: integrating GPCR sequence, structure and function
- (2020) Albert J Kooistra et al. NUCLEIC ACIDS RESEARCH
- Cryo-EM structures of GPCRs coupled to Gs, Gi and Go
- (2019) Javier García-Nafría et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Structural Insights into the Process of GPCR-G Protein Complex Formation
- (2019) Xiangyu Liu et al. CELL
- Assembly of a GPCR-G Protein Complex
- (2019) Yang Du et al. CELL
- Software tools for automated transmission electron microscopy
- (2019) Martin Schorb et al. NATURE METHODS
- Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes
- (2019) Shoji Maeda et al. SCIENCE
- Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development
- (2019) Javier García-Nafría et al. Annual Review of Pharmacology and Toxicology
- Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation
- (2019) Yang Gao et al. MOLECULAR CELL
- Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
- (2018) Javier García-Nafría et al. eLife
- Real-space refinement in PHENIX for cryo-EM and crystallography
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
- (2018) Yi-Lynn Liang et al. NATURE
- Structure of the µ-opioid receptor–Gi protein complex
- (2018) Antoine Koehl et al. NATURE
- Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
- (2018) Yi-Lynn Liang et al. NATURE
- Development of an antibody fragment that stabilizes GPCR/G-protein complexes
- (2018) Shoji Maeda et al. Nature Communications
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
- (2017) Yi-Lynn Liang et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- A pipeline approach to single-particle processing inRELION
- (2017) Rafael Fernandez-Leiro et al. Acta Crystallographica Section D-Structural Biology
- Mini-G proteins: Novel tools for studying GPCRs in their active conformation
- (2017) Rony Nehmé et al. PLoS One
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Structure of the adenosine A2A receptor bound to an engineered G protein
- (2016) Byron Carpenter et al. NATURE
- Cryo-Electron Microscopy Modeling by the Molecular Dynamics Flexible Fitting Method
- (2012) Kwok-Yan Chan et al. BIOPOLYMERS
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
- (2011) Roman A. Laskowski et al. Journal of Chemical Information and Modeling
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Structural flexibility of the G s -helical domain in the 2-adrenoceptor Gs complex
- (2011) G. H. Westfield et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started