Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice

De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation

(2020) Dongxue Mao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B

(2020) Alisa F. Zyryanova et al.   MOLECULAR CELL

HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors

(2019) Jia Cheng et al.   NEURON

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

(2019) Salil Saurav Pathak et al.   NEURON

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

(2018) Tommaso Patriarchi et al.   SCIENCE

Development of a stress response therapy targeting aggressive prostate cancer

(2018) Hao G. Nguyen et al.   Science Translational Medicine

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

(2018) Yao Liang Wong et al.   eLife

Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq

(2018) Ana B. Muñoz-Manchado et al.   Cell Reports

Dual Dopaminergic Regulation of Corticostriatal Plasticity by Cholinergic Interneurons and Indirect Pathway Medium Spiny Neurons

(2018) Shana M. Augustin et al.   Cell Reports

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

(2018) Roberta Cagnetta et al.   MOLECULAR CELL

Protection of tissue physicochemical properties using polyfunctional crosslinkers

(2018) Young-Gyun Park et al.   NATURE BIOTECHNOLOGY

Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors

(2017) Jung Hoon Shin et al.   JOURNAL OF NEUROSCIENCE

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

(2017) Z D Kabir et al.   MOLECULAR PSYCHIATRY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior

(2017) Justin K O'Hare et al.   eLife

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Pathway-Specific Striatal Substrates for Habitual Behavior

(2016) Justin K. O’Hare et al.   NEURON

Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia

(2016) Joseph E. Rittiner et al.   NEURON

Translation from the 5' untranslated region shapes the integrated stress response

(2016) S. R. Starck et al.   SCIENCE

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

(2016) Wei Huang et al.   eLife

Dopamine Is Required for the Neural Representation and Control of Movement Vigor

(2015) Babita Panigrahi et al.   CELL

Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems

(2015) Evan Murray et al.   CELL

PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE  4 Human Replacement Mice

(2015) Y. Segev et al.   JOURNAL OF NEUROSCIENCE

Stochastic electrotransport selectively enhances the transport of highly electromobile molecules

(2015) Sung-Yon Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

(2013) Mimi A. Trinh et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Dopamine Modulates Reward-Related Vigor

(2013) Ulrik Beierholm et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

(2012) Nicolas X. Tritsch et al.   NEURON

Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons

(2012) Sarah Threlfell et al.   NEURON

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior

(2012) J. L. Warner-Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylcholine-dopamine balance hypothesis in the striatum: An update

(2010) Toshihiko Aosaki et al.   Geriatrics & Gerontology International

Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

(2010) David M. Lovinger   NEUROPHARMACOLOGY

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

(2010) I. B. Witten et al.   SCIENCE

Adenylyl Cyclase Type 5 Contributes to Corticostriatal Plasticity and Striatum-Dependent Learning

(2009) M. A. Kheirbek et al.   JOURNAL OF NEUROSCIENCE

Nonequilibrium Calcium Dynamics Regulate the Autonomous Firing Pattern of Rat Striatal Cholinergic Interneurons

(2009) J. A. Goldberg et al.   JOURNAL OF NEUROSCIENCE

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON