Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy

Mu-Xiang-You-Fang protects PC12 cells against OGD/R-induced autophagy via the AMPK/mTOR signaling pathway

(2020) Hui-xia Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

The role of autophagy in the pathogenesis of ischemic stroke

(2020) Qianyu Shi et al.   Current Neuropharmacology

Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro

(2020) Jie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Memantine ameliorates tau protein deposition and secondary damage in the ipsilateral thalamus and sensory decline following focal cortical infarction in rats

(2020) Yu-Bin Liang et al.   NEUROSCIENCE LETTERS

Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy

(2020) Qi Zhang et al.   MOLECULES

Isolation, structure elucidation and neuroprotective effects of caffeoylquinic acid derivatives from the roots of Arctium lappa L.

(2020) Huan Gao et al.   PHYTOCHEMISTRY

DCMQA, a caffeoylquinic acid derivative alleviates NMDA-induced neurotoxicity via modulating GluN2A and GluN2B-containing NMDA receptors in vitro

(2020) Yue Yang et al.   TOXICOLOGY IN VITRO

Oleoylethanolamide inhibits glial activation via moudulating PPARα and promotes motor function recovery after brain ischemia

(2019) Doudou Luo et al.   PHARMACOLOGICAL RESEARCH

Crosstalk Between Autophagy and Cerebral Ischemia

(2019) Yulin Sun et al.   Frontiers in Neuroscience

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

(2019) Syed Suhail Andrabi et al.   Disease Models & Mechanisms

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

(2019) Ding-Mei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Theaflavic acid from black tea protects PC12 cells against ROS-mediated mitochondrial apoptosis induced by OGD/R via activating Nrf2/ARE signaling pathway

(2019) Yan Li et al.   Journal of Natural Medicines

Guaiane-Type Sesquiterpenoids from the Roots of Daphne genkwa and Evaluation of Their Neuroprotective Effects

(2019) Qiang Ren et al.   JOURNAL OF NATURAL PRODUCTS

Intermittent compressive force promotes osteogenic differentiation in human periodontal ligament cells by regulating the transforming growth factor-β pathway

(2019) Jeeranan Manokawinchoke et al.   Cell Death & Disease

Lycium barbarum polysaccharide alleviates oxygen glucose deprivation-induced PC-12 cells damage by up-regulating miR-24

(2019) Shiqing Song et al.   Artificial Cells Nanomedicine and Biotechnology

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke

(2018) Bing Han et al.   Autophagy

Autophagy in ischemic stroke

(2018) Pei Wang et al.   PROGRESS IN NEUROBIOLOGY

Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke

(2018) Kelly M. DeMars et al.   Frontiers in Neuroscience

AMPK: Potential Therapeutic Target for Ischemic Stroke

(2018) Shuai Jiang et al.   Theranostics

Mechanical thrombectomy in acute ischemic stroke

(2017) L. Derex et al.   REVUE NEUROLOGIQUE

Inhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy

(2016) Le Fu et al.   BRAIN RESEARCH

Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis

(2016) Yaqiong Zhang et al.   NEUROCHEMICAL RESEARCH

Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/−9 and heparanase in MDA-MB-231 cells

(2016) Chenghua Lou et al.   ONCOLOGY REPORTS

Caffeoylquinic acid derivatives from the roots of Arctium lappa L. (burdock) and their structure–activity relationships (SARs) of free radical scavenging activities

(2016) Xiao-Wen Jiang et al.   Phytochemistry Letters

Antioxidant and cognitive-enhancing activities of Arctium lappa L. roots in Aβ1-42-induced mouse model

(2016) Yoon Kyung Kwon et al.   Applied Biological Chemistry

Autophagy: an emerging therapeutic target in vascular diseases

(2015) Cécile Vindis   BRITISH JOURNAL OF PHARMACOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Antioxidant Activity of Arctium lappa L. and Its Effect on Biochemical Parameters in Exercised Rats

(2014)   ASIAN JOURNAL OF CHEMISTRY

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Protective Effects of Arctium lappa L. Roots Against Hydrogen Peroxide-Induced Cell Injury and Potential Mechanisms in SH-SY5Y Cells

(2014) Xing Tian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective effects of Arctium lappa L. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, JNK and ERK 1/2 MAPKs in PC12 cells

(2014) Xing Tian et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Effects ofArctium lappaL. (Burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis

(2014) Leila Maghsoumi-Norouzabad et al.   International Journal of Rheumatic Diseases

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Myricitrin attenuates 6-hydroxydopamine-induced mitochondrial damage and apoptosis in PC12 cells via inhibition of mitochondrial oxidation

(2013) Yue-Hua Wang et al.   Journal of Functional Foods

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Neuroprotective Effects of Biochanin A Against Glutamate-Induced Cytotoxicity in PC12 Cells Via Apoptosis Inhibition

(2012) Ji Wei Tan et al.   NEUROCHEMICAL RESEARCH

Salvianolic Acid B Protects SH-SY5Y Neuroblastoma Cells from 1-Methyl-4-phenylpyridinium-Induced Apoptosis

(2010) Guang Zeng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

In Vitro and In Vivo Anti-Allergic Effects of Arctium lappa L.

(2008) Karen Knipping et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE