Article
Nutrition & Dietetics
Doudou Li, Xiaoke Zhang, Yanna Fan, Yannan Zhang, Xiujuan Tao, Jianjun Yang
Summary: The study found that Lycium barbarum polysaccharides (LBPs) can improve glucose homeostasis by reducing duodenal contraction amplitude in prediabetic mice. LBPs also improve gut microbiota composition and short-chain fatty acid levels, particularly acetic acid, which regulates duodenal contraction by binding to receptors on neurons.
Article
Chemistry, Applied
Jixian Zhang, Xue Yang, Tao Ji, Chaoting Wen, Zhiqiang Ye, Xiaofang Liu, Li Liang, Guoyan Liu, Xin Xu
Summary: The study investigated the digestion and absorption properties of Lycium barbarum polysaccharides stabilized selenium nanoparticles (LBP-SeNPs). Results showed that LBP-SeNPs can better maintain the morphology and properties of nano particles during the digestion process, leading to improved selenium bioavailability. The selenium release rate and particle size of SeNPs and LBP-SeNPs changed significantly during digestion, with LBP-SeNPs showing higher stability and absorption efficiency.
Article
Food Science & Technology
Feng Lu, Rongrong Zhai, Siyu Ruan, Xue Yang, Evans A. Alenyorege, Yucheng Wang, Yanhua Ding, Haile Ma
Summary: The study found that ultrasound can improve the decoloration process of Lycium barbarum polysaccharides on resins and enhance their dynamic desorption effect. By optimizing conditions, a better desorption effect can be achieved.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Yafei Zhu, Qipeng Zhao, Yideng Jiang
Summary: The study showed that LBP attenuates diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Chao Yang, Hui Xia, Huali Tang, Ligang Yang, Guiju Sun
Summary: This study successfully established a quantitative determination method for Lycium barbarum polysaccharides (LBPs) using fluorescein isothiocyanate (FITC) pre-labeling and investigated their tissue distribution in rats. The results showed that LBPs were mainly absorbed by the small intestine and stomach and excreted through the kidney. These findings contribute to a comprehensive understanding of the biological effects of LBPs.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Run-Hui Ma, Xiu-Xiu Zhang, Kiran Thakur, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Lycium genus is recognized as a promising source of novel bioactive compounds with diverse biological activities. Research has mainly focused on the chemical constituents and pharmacological properties of L. barbarum L. berries in traditional medicine. Apart from its medicinal use, L. barbarum L. berries and related food products are regarded as dietary supplements or 'superfoods' due to their significant health potential without explicit toxicity. Through a holistic approach, this study provides recent data on the chemical ingredients, their structural characterization, and emphasizes the extensive in vitro and in vivo health effects of L. barbarum L. berries.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Food Science & Technology
Hui Xia, Chao Yang, Beijia Zhou, Huali Tang, Ligang Yang, Wang Liao, Guiju Sun
Summary: A high-performance gel permeation chromatography fluorescence detection method combined with FITC labeling was established for the microanalysis of LBP, showing slow elimination of LBP from plasma and prolonged retention in the intestine with most of it being excreted in feces.
Article
Chemistry, Applied
Zhendong He, Tianyi Ma, Weiwei Zhang, Erzheng Su, Fuliang Cao, Meigui Huang, Yaosong Wang
Summary: The study showed that composite gels with 0.1% Lycium barbarum polysaccharides exhibited the greatest functional value, while gels with 1% LBP had higher porosity. Whey protein formed different types of gels at varying pH levels, but showed no significant difference in hydration properties.
FOOD HYDROCOLLOIDS
(2021)
Review
Pharmacology & Pharmacy
Zhiyong Xiao, Qi Deng, Wenxia Zhou, Yongxiang Zhang
Summary: Lycium barbarum polysaccharides (LBPs), the most valuable and well-researched component of Lycium barbarum, possess antiaging, antidiabetic, antifibrotic, neuroprotective, and immunomodulation properties. Recent studies have provided insights into the structure-activity relationships, receptor recognition, and gut microbiota modulation of LBPs.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Guoyan Liu, Xue Yang, Jixian Zhang, Li Liang, Feng Miao, Tao Ji, Zhiqiang Ye, Meng Chu, Jiaoyan Ren, Xin Xu
Summary: The study demonstrated that Lycium barbarum polysaccharides (LBP), specifically LBP1, can be used as stabilizers and capping agents for uniformly dispersed selenium nanoparticles (SeNPs) with excellent stability. LBP1-decorated SeNPs showed smaller particle size and enhanced fatigue-relieving activity, as indicated by prolonged swimming time and improved biochemical markers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Zexiao Fan, Yue Zhang, Lina Jiao, Tianyu Zhu, Zian Feng, Zhenguang Liu, Yang Yang, Deyun Wang
Summary: The Lycium barbarum polysaccharides-loaded Particulate Alum via Pickering emulsion (LBPPE) prepared by Pickering emulsion has high antigen loading efficiency and stability, which makes it a promising and safe adjuvant platform for vaccines.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Haoran Xing, Xuguang Liu, Yunfeng Hu, Kailei Hu, Junran Chen
Summary: This study investigated the impact and mechanism of Lycium barbarum polysaccharides (LBP) on the gelling behavior of soy protein isolate (SPI). The results showed that the addition of LBP improved the gel strength, water-holding capacity, and viscoelastic properties of SPI gel in a concentration-dependent manner. LBP also enhanced the thermal stability of SPI. The study further revealed that electrostatic and hydrophobic interactions played a critical role in the formation of the SPI-LBP gel composite.
FOOD HYDROCOLLOIDS
(2024)
Article
Chemistry, Applied
Xiu-Xiu Zhang, Zhi-Jing Ni, Fan Zhang, Kiran Thakur, Jian-Guo Zhang, Mohammad Rizwan Khan, Rosa Busquets, Zhao-Jun Wei
Summary: This study investigated the physicochemical and anti-oxidant properties of Lycium barbarum seed dreg polysaccharides (LBSDPs) extracted with different solvents. The results showed that these polysaccharides had different monosaccharide compositions and molecular weights, as well as different antioxidant capacity and functional properties. The study provides a theoretical basis for further exploring the potential applications of LBSDPs in functional food and cosmetics industries.
Article
Food Science & Technology
Huimin Li, Weihua Tao, Xiaochun Xu, Guolin Chen, Wenping Ma, Shiqi Jia
Summary: Pancreatic β-cell death mediated by apoptosis is crucial in diabetes development. Pro-inflammatory cytokines activate the apoptotic program in pancreatic β-cells. Thus, inhibiting apoptosis induced by inflammatory cytokines can protect pancreatic β-cells. In this study, we found that Lycium barbarum polysaccharides (LBP) can alleviate pancreatic β-cell apoptosis through the inhibition of the interferon-γ pathway. LBP administration improved glucose tolerance in healthy mice and protected against hyperglycemia in streptozotocin-induced β-cells injury mice.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cell Biology
Li-Xia Xue, Lin-Yuan Shu, Hong-Mei Wang, Kai-Li Lu, Li-Gang Huang, Jing-Yan Xiang, Zhi Geng, Yu-Wu Zhao, Hao Chen
Summary: Promoting new blood vessel formation is a new strategy for treating ischemic stroke, and non-coding miRNAs have been considered potential therapeutic targets for this condition. In this study, overexpression of miR-181b in brain microvascular endothelial cells restored cell proliferation and enhanced angiogenesis in vitro. In rat models of focal cerebral ischemia, overexpression of miR-181b reduced infarction volume, promoted angiogenesis, and improved neurological function. The molecular mechanism behind these effects involves miR-181b binding to PTEN mRNA to induce downregulation, leading to PTEN/Akt pathway activation, upregulated expression of vascular endothelial growth factors, downregulated expression of endostatin, and promoted angiogenesis.
NEURAL REGENERATION RESEARCH
(2023)
