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Title
TRIM21 – A potential novel therapeutic target in cancer
Authors
Keywords
Cancer proliferation, Proteasomal degradation, NF-κB, p53, HuR, GMPS
Journal
PHARMACOLOGICAL RESEARCH
Volume 165, Issue -, Pages 105443
Publisher
Elsevier BV
Online
2021-01-27
DOI
10.1016/j.phrs.2021.105443
References
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Note: Only part of the references are listed.- LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma
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- Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif–containing 21
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- Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus
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- Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction
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- The Sjögren's syndrome-associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production
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- Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer
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- TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells
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- TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model
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- Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T H 1/T H 17 cell differentiation in patients with inflammatory bowel diseases
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- TRIM21 and the Function of Antibodies inside Cells
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- TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
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- Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress
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- Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease
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- Downregulation of TRIM21 contributes to hepatocellular carcinoma carcinogenesis and indicates poor prognosis of cancers
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- Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response
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- The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN- Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3
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- Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization
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- Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
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- IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor-Initiated Apoptosis via Repression of FLICE-like Protein Expression
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- Ro52-mediated Monoubiquitination of IKK Down-regulates NF- B Signalling
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- Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway
- (2009) Alexander Espinosa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Sequestosome 1/p62 Attenuates Cytokine Gene Expression in Activated Macrophages by Inhibiting IFN Regulatory Factor 8 and TNF Receptor-Associated Factor 6/NF- B Activity
- (2009) J. Y. Kim et al. JOURNAL OF IMMUNOLOGY
- Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF- B-Dependent Cytokine Expression in Fibroblasts
- (2009) R. Yoshimi et al. JOURNAL OF IMMUNOLOGY
- TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved
- (2008) A. H. Keeble et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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