Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

SnapShot: Ferroptosis

(2020) Kamyar Hadian et al.   CELL

Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy

(2020) Aishika Datta et al.   Translational Stroke Research

Ferroptosis in Neurological Diseases

(2020) Jia-Xin Ren et al.   Frontiers in Cellular Neuroscience

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

The Potential Role of Ferroptosis in Neonatal Brain Injury

(2019) Yanan Wu et al.   Frontiers in Neuroscience

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

(2019) Núria DeGregorio-Rocasolano et al.   Frontiers in Neuroscience

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

(2019) Salil Saurav Pathak et al.   NEURON

The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment

(2019) Nao Yan et al.   Frontiers in Neuroscience

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro

(2019) Takujiro Homma et al.   EXPERIMENTAL CELL RESEARCH

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models

(2018) H. Karatas et al.   BRAIN RESEARCH

The role of Ca 2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

(2018) Pamela Maher et al.   CELL CALCIUM

Regulation of lipid peroxidation and ferroptosis in diverse species

(2018) Marcus Conrad et al.   GENES & DEVELOPMENT

Iron as a therapeutic target for Parkinson's disease

(2018) Caroline Moreau et al.   MOVEMENT DISORDERS

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

(2018) Nuria DeGregorio-Rocasolano et al.   Redox Biology

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders

(2018) Jia-rui Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The in vivo evidence for regulated necrosis

(2017) Wulf Tonnus et al.   IMMUNOLOGICAL REVIEWS

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

(2017) Meng-Shian Chen et al.   Oncotarget

GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells

(2016) Kevin M. Mazor et al.   AMINO ACIDS

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction

(2016) Desiree Wanders et al.   DIABETES

Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

(2016) Rongrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Glutathione peroxidase 4: a new player in neurodegeneration?

(2016) B R Cardoso et al.   MOLECULAR PSYCHIATRY

Oxidized PEs trigger death

(2016) Katharina D'Herde et al.   Nature Chemical Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

(2016) Saravanan S. Karuppagounder et al.   Science Translational Medicine

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

The Use of microRNAs to Modulate Redox and Immune Response to Stroke

(2015) Yi-Bing Ouyang et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy—mediated cell death

(2015) C. Descloux et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The role of Nrf2 in oxidative stress-induced endothelial injuries

(2015) B. Chen et al.   JOURNAL OF ENDOCRINOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Link Between Oxidative Stress and Acute Brain Ischemia

(2013) Djordje Radak et al.   ANGIOLOGY

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke

(2013) Rachel E. Speer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique

(2013) Salil Srivastava et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

(2013) Julien Puyal et al.   PROGRESS IN NEUROBIOLOGY

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress

(2013) N Henke et al.   Cell Death & Disease

4-hydroxy-2(E)-Nonenal facilitates NMDA-Induced Neurotoxicity via Triggering Mitochondrial Permeability Transition Pore Opening and Mitochondrial Calcium Overload

(2013) In-Young Choi et al.   Experimental Neurobiology

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

(2012) Kazim Yigitkanli et al.   ANNALS OF NEUROLOGY

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

(2012) Ashlee Higdon et al.   BIOCHEMICAL JOURNAL

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression

(2012) Linyu Chen et al.   BRAIN RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?

(2012) Saravanan S Karuppagounder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

(2012) Silvia Manzanero et al.   NEUROCHEMISTRY INTERNATIONAL

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

(2011) J Lewerenz et al.   CELL DEATH AND DIFFERENTIATION

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Modulatory profiling identifies mechanisms of small molecule-induced cell death

(2011) A. J. Wolpaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat

(2010) Ui Jin Park et al.   ACTA NEUROPATHOLOGICA

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression of Keap1–Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion

(2010) Nobuhito Tanaka et al.   BRAIN RESEARCH

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

(2009) Stefanie Pallast et al.   JOURNAL OF NEUROCHEMISTRY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation

(2008) Claus Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activating transcription factor 4

(2007) Kurosh Ameri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY