STAT3 phosphorylation in central leptin resistance

Leptin stimulates autophagy/lysosome-related degradation of long-lived proteins in adipocytes

(2019) Nir Goldstein et al.   Adipocyte

STAT3beta, a distinct isoform from STAT3

(2019) Hui-Xiang Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transcriptional and physiological roles for STAT proteins in leptin action

(2019) Warren Pan et al.   Molecular Metabolism

Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

(2019) Andrea G. Izquierdo et al.   Nutrients

Role of POMC and AgRP neuronal activities on glycaemia in mice

(2019) Aykut Göktürk Üner et al.   Scientific Reports

STAT3 isoforms: Alternative fates in cancer?

(2018) Petra Aigner et al.   CYTOKINE

DNA-binding activity of STAT3 increased in hypothalamus of DIO mice; the reduction of STAT3 phosphorylation may facilitate leptin signaling

(2018) Liang Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice

(2018) Luke Harrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin signalling pathways in hypothalamic neurons

(2016) Obin Kwon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tackling myocardial ischemic injury: the signal transducer and activator of transcription 3 (STAT3) at a good site

(2016) Yang Yang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

(2016) Zhenxing Liang et al.   PROGRESS IN NEUROBIOLOGY

The soluble leptin receptor

(2015) Michael Schaab et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

New insights in leptin resistance mechanisms in mice

(2015) Eglantine Balland et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Leptin resistance in obesity: An epigenetic landscape

(2015) Ana B. Crujeiras et al.   LIFE SCIENCES

Leptin resistance and diet-induced obesity: central and peripheral actions of leptin

(2015) Neira Sáinz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Structure, production and signaling of leptin

(2015) Heike Münzberg et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leptin applications in 2015

(2015) Olivia M. Farr et al.   Current Opinion in Endocrinology Diabetes and Obesity

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma

(2015) Heba Alshaker et al.   Oncotarget

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

(2015) Jong Hyun Lee et al.   Oncotarget

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

A Missing Link in Body Weight Homeostasis: The Catabolic Signal of the Overfed State

(2014) Yann Ravussin et al.   Cell Metabolism

Differential Modulation of Arcuate Nucleus and Mesolimbic Gene Expression Levels by Central Leptin in Rats on Short-Term High-Fat High-Sugar Diet

(2014) José K. van den Heuvel et al.   PLoS One

Downregulation of signal transducer and activator of transcription 3 by sorafenib: A novel mechanism for hepatocellular carcinoma therapy

(2014) Man-Hsin Hung   WORLD JOURNAL OF GASTROENTEROLOGY

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

(2014) Kavon Rezai-Zadeh et al.   Molecular Metabolism

Essential role of IL-10/STAT3 in chronic stress-induced immune suppression

(2013) Dan Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

Regulation of STAT signaling by acetylation

(2013) Shougang Zhuang   CELLULAR SIGNALLING

Environment, Leptin Sensitivity, and Hypothalamic Plasticity

(2013) Marco Mainardi et al.   NEURAL PLASTICITY

Leptin signaling and leptin resistance

(2013) Yingjiang Zhou et al.   Frontiers of Medicine

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

(2012) Ivan H. W. Ng et al.   BIOCHEMICAL JOURNAL

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals

(2012) Z. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity

(2012) Kevin M. Gamber et al.   PLoS One

Potential Distribution of the Australian Native Chloris truncata Based on Modelling Both the Successful and Failed Global Introductions

(2012) Pippa J. Michael et al.   PLoS One

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sixteen years and counting: an update on leptin in energy balance

(2011) Laurent Gautron et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

(2011) P. J. Enriori et al.   JOURNAL OF NEUROSCIENCE

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

(2011) K. W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice

(2010) David L. Morris et al.   ENDOCRINOLOGY

Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance

(2010) J. You et al.   MOLECULAR AND CELLULAR BIOLOGY

Hyperleptinemia Is Required for the Development of Leptin Resistance

(2010) Zachary A. Knight et al.   PLoS One

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC

(2009) Martin G. Myers et al.   Cell Metabolism

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats

(2009) F. I. Milagro et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Large, rare chromosomal deletions associated with severe early-onset obesity

(2009) Elena G. Bochukova et al.   NATURE

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

(2008) Christy L. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

(2008) K. Rahmouni et al.   DIABETES

Signal Transducer and Activator of Transcription-3 Is Required in Hypothalamic Agouti-Related Protein/Neuropeptide Y Neurons for Normal Energy Homeostasis

(2008) Lijie Gong et al.   ENDOCRINOLOGY

FoxO1 Inhibits Leptin Regulation of Pro-opiomelanocortin Promoter Activity by Blocking STAT3 Interaction with Specificity Protein 1

(2008) Guoqing Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin Resistance

(2008) Seth S. Martin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endoplasmic Reticulum Stress Induces Leptin Resistance

(2008) T. Hosoi et al.   MOLECULAR PHARMACOLOGY

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity

(2008) Ji-Yeon Lee et al.   PLoS One

Mechanisms of Leptin Action and Leptin Resistance

(2007) Martin G. Myers et al.   Annual Review of Physiology