Targeted pharmacotherapy against neurodegeneration and neuroinflammation in early diabetic retinopathy

Loss of β-catenin via activated GSK3β causes diabetic retinal neurodegeneration by instigating a vicious cycle of oxidative stress-driven mitochondrial impairment

(2020) Xing-Sheng Shu et al.   Aging-US

Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a

(2019) Qianqian Shi et al.   LIFE SCIENCES

Nutraceuticals for the Treatment of Diabetic Retinopathy

(2019) Maria Grazia Rossino et al.   Nutrients

New Insights into the Mechanisms of Action of Topical Administration of GLP-1 in an Experimental Model of Diabetic Retinopathy

(2019) Joel Sampedro et al.   Journal of Clinical Medicine

SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes

(2019) Cristina Hernández et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effects of Ginsenoside Rg1 against Hyperphosphorylated Tau-Induced Diabetic Retinal Neurodegeneration via Activation of IRS-1/Akt/GSK3β Signaling

(2019) Ying Ying et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling

(2019) Xingsheng Shu et al.   NEUROPHARMACOLOGY

Effect of rutin on retinal VEGF, TNF-α, aldose reductase, and total antioxidant capacity in diabetic rats: molecular mechanism and ocular pharmacokinetics

(2019) Suresh Kumar Gupta et al.   INTERNATIONAL OPHTHALMOLOGY

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells

(2019) Chunlan Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurodegeneration in diabetic retinopathy: does it really matter?

(2018) Rafael Simó et al.   DIABETOLOGIA

Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy

(2018) Amna Parveen et al.   MOLECULES

Effects of Liposomal Formulation of Citicoline in Experimental Diabetes-Induced Retinal Neurodegeneration

(2018) Patricia Bogdanov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Topically Administered Neuroprotective Drugs in Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial

(2018) Rafael Simó et al.   DIABETES

Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes

(2018) Patricia Bogdanov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

(2018) Huazhang Zhu et al.   Molecular Neurodegeneration

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons

(2017) Roberto Piacentini et al.   GLIA

Inhibition of GSK-3β Activation Protects SD Rat Retina Against N-Methyl-N-Nitrosourea-Induced Degeneration by Modulating the Wnt/β-Catenin Signaling Pathway

(2017) Baoying Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Do photoreceptor cells cause the development of retinal vascular disease?

(2017) Timothy S. Kern   VISION RESEARCH

Müller cells and diabetic retinopathy

(2017) Brandon A. Coughlin et al.   VISION RESEARCH

Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice

(2017) Xiang Ren et al.   Oncotarget

Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet–Induced Diabetic Retinopathy

(2016) Rithwick Rajagopal et al.   DIABETES

Crude Saponins of Panax notoginseng Have Neuroprotective Effects To Inhibit Palmitate-Triggered Endoplasmic Reticulum Stress-Associated Apoptosis and Loss of Postsynaptic Proteins in Staurosporine Differentiated RGC-5 Retinal Ganglion Cells

(2016) Dan-dan Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy

(2016) Saif Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

The importance of glial cells in the homeostasis of the retinal microenvironment and their pivotal role in the course of diabetic retinopathy

(2016) Francesco Saverio Sorrentino et al.   LIFE SCIENCES

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

(2016) Elliott H. Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy

(2016) J-H Yun et al.   Cell Death & Disease

Diabetic retinopathy

(2016) Tien Y. Wong et al.   Nature Reviews Disease Primers

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis

(2015) Dong-Il Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice

(2015) De-Lin Ma et al.   JOURNAL OF NEUROCHEMISTRY

Early retinal pigment epithelium dysfunction is concomitant with hyperglycemia in mouse models of type 1 and type 2 diabetes

(2015) Ivy S. Samuels et al.   JOURNAL OF NEUROPHYSIOLOGY

Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy

(2014) Rafael Simó et al.   DIABETES CARE

Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: Implications for axonal transport

(2014) Filipa I. Baptista et al.   EXPERIMENTAL EYE RESEARCH

Pioglitazone Normalizes Insulin Signaling in the Diabetic Rat Retina through Reduction in Tumor Necrosis Factor α and Suppressor of Cytokine Signaling 3

(2014) Youde Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ocular Inflammation and Endoplasmic Reticulum Stress Are Attenuated by Supplementation with Grape Polyphenols in Human Retinal Pigmented Epithelium Cells and in C57BL/6 Mice

(2014) Jung-Heun Ha et al.   JOURNAL OF NUTRITION

Differential regulation of the glutamate transporters GLT-1 and GLAST by GSK3β

(2014) Esperanza Jiménez et al.   NEUROCHEMISTRY INTERNATIONAL

High Glucose Alters Retinal Astrocytes Phenotype through Increased Production of Inflammatory Cytokines and Oxidative Stress

(2014) Eui Seok Shin et al.   PLoS One

Functional architecture of the retina: Development and disease

(2014) Mrinalini Hoon et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications

(2013) Maxwell Stem et al.   CURRENT MEDICINAL CHEMISTRY

NRF2 plays a protective role in diabetic retinopathy in mice

(2013) Zhenhua Xu et al.   DIABETOLOGIA

Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain

(2013) Han-Rong Weng et al.   EXPERIMENTAL NEUROLOGY

Inflammation and Pharmacological Treatment in Diabetic Retinopathy

(2013) Snježana Kaštelan et al.   MEDIATORS OF INFLAMMATION

Inhibition of glycogen synthase kinase-3β by lithium chloride suppresses 6-hydroxydopamine-induced inflammatory response in primary cultured astrocytes

(2013) Hong-Mei Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis

(2013) Evgeniy Panzhinskiy et al.   PLoS One

PKCζ Mediates Breakdown of Outer Blood-Retinal Barriers in Diabetic Retinopathy

(2013) Samy Omri et al.   PLoS One

Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina

(2013) Y. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal Layers Changes in Human Preclinical and Early Clinical Diabetic Retinopathy Support Early Retinal Neuronal and Müller Cells Alterations

(2013) Stela Vujosevic et al.   Journal of Diabetes Research

Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications

(2012) Rafael Simó et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Neuroprotection in Diabetic Retinopathy

(2012) Cristina Hernández et al.   Current Diabetes Reports

Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy

(2012) K. Lee et al.   DIABETES

Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications in C57BL/6J Mice

(2012) Vishnupriya Gourineni et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Early Distal Axonopathy of the Visual Pathway in Experimental Diabetes

(2011) Diego C. Fernandez et al.   AMERICAN JOURNAL OF PATHOLOGY

Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades

(2011) Mei-Jen Wang et al.   Journal of Neuroinflammation

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

Gene Expression Profiling of Vasoregression in the Retina—Involvement of Microglial Cells

(2011) Yuxi Feng et al.   PLoS One

EARLY NEURAL AND VASCULAR CHANGES IN THE ADOLESCENT TYPE 1 AND TYPE 2 DIABETIC RETINA

(2011) Kevin W Bronson-Castain et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

(2011) D Nguyen et al.   Cell Death & Disease

Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy

(2010) Mien V. Hoang et al.   ANGIOGENESIS

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

(2010) J.M. Gaspar et al.   NEUROSCIENCE

PTP1B: a double agent in metabolism and oncogenesis

(2010) Shu-Chin Yip et al.   TRENDS IN BIOCHEMICAL SCIENCES

Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

(2010) Hille W. van Dijk et al.   VISION RESEARCH

Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-induced diabetic rats

(2009) Bang V. Bui et al.   EXPERIMENTAL EYE RESEARCH

Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

(2009) Eléonore Beurel et al.   TRENDS IN IMMUNOLOGY

Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina

(2008) Heather D. VanGuilder et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition

(2008) Y. Leng et al.   JOURNAL OF NEUROSCIENCE

Wnt signaling in neuroprotection and stem cell differentiation

(2008) Enrique M. Toledo et al.   PROGRESS IN NEUROBIOLOGY

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY