Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 64, Issue 7, Pages 1528-1539Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b05864
Keywords
CSPN; palmitate; differentiated RGC-5 cells; apoptosis; PSD-95; ER stress; ROS
Funding
- National Science Foundation of China [81200602]
- Basic Research Foundation of Shenzhen [JCYJ20140418091413550]
- Shenzhen Strategic Emerging Industry Development Project [SEG[2013]180, KQCX20140522111508785, CXZZ20150601110000604, ZDSYS201506031617582]
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Increased apoptosis of retinal ganglion cells (RGCs) contributes to the gradual loss of retinal neurons at the early phase of diabetic retinopathy (DR). There is an urgent need to search for drugs with neuroprotective effects against apoptosis of RGCs for the early treatment of DR This study aimed to investigate the neuroprotective effects of saponins extracted from Panax notoginseng, a traditional Chinese medicine, on apoptosis of RGCs stimulated by palmitate, a metabolic factor for the development of diabetes and its complications, and to explore the potential molecular mechanism. We showed that crude saponins of P. notoginseng (CSPN) inhibited the increased apoptosis and loss of postsynaptic protein PSD-95 by palmitate in staurosporine-differentiated RGC-5 cells. Moreover, CSPN suppressed palmitate-induced reactive oxygen species generation and endoplasmic reticulum stress-associated eIF2 alpha/ATF4/CHOP and caspase 12 pathways. Thus, our findings address the potential therapeutic significance of CSPN for the early stage of DR.
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