Orthogonal Genetic Systems

A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids

(2019) Sebastian Arangundy-Franklin et al.   Nature Chemistry

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

(2019) Elena Eremeeva et al.   NUCLEIC ACIDS RESEARCH

Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning

(2019) Ali Nikoomanzar et al.   ACS Synthetic Biology

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase

(2019) Lynnette N Jackson et al.   NUCLEIC ACIDS RESEARCH

Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues

(2018) Hui Mei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of aptamer discovery and technology

(2017) Matthew R. Dunn et al.   Nature Reviews Chemistry

Coming of age: ten years of next-generation sequencing technologies

(2016) Sara Goodwin et al.   NATURE REVIEWS GENETICS

A general strategy for expanding polymerase function by droplet microfluidics

(2016) Andrew C. Larsen et al.   Nature Communications

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties

(2015) Mohitosh Maiti et al.   NUCLEIC ACIDS RESEARCH

The structural diversity of artificial genetic polymers

(2015) Irina Anosova et al.   NUCLEIC ACIDS RESEARCH

Expanding and Reprogramming the Genetic Code of Cells and Animals

(2014) Jason W. Chin   Annual Review of Biochemistry

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Large-scale de novo DNA synthesis: technologies and applications

(2014) Sriram Kosuri et al.   NATURE METHODS

The Emerging World of Synthetic Genetics

(2012) John C. Chaput et al.   CHEMISTRY & BIOLOGY

The solution structure of double helical arabino nucleic acids (ANA and 2′F-ANA): effect of arabinoses in duplex-hairpin interconversion

(2012) Nerea Martín-Pintado et al.   NUCLEIC ACIDS RESEARCH

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acids (dXNA): An Orthogonal Nucleic Acid Candidate

(2011) Mohitosh Maiti et al.   CHEMISTRY-A EUROPEAN JOURNAL

Xenobiology: A new form of life as the ultimate biosafety tool

(2010) Markus Schmidt   BIOESSAYS

Geometrical correlations in the nucleosomal DNA conformation and the role of the covalent bonds rigidity

(2010) M. Ghorbani et al.   NUCLEIC ACIDS RESEARCH

Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids

(2009) Piet Herdewijn et al.   CHEMISTRY & BIODIVERSITY

Polymerase-Catalysed Incorporation of Glucose Nucleotides into a DNA Duplex

(2009) Marleen Renders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Helical Structure of Xylose-DNA

(2009) Amutha Ramaswamy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Structure of a TNA−TNA Complex in Solution: NMR Study of the Octamer Duplex Derived from α-(l)-Threofuranosyl-(3′-2′)-CGAATTCG

(2008) Marc-Olivier Ebert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected A-form formation of 4′-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance

(2008) Akimasa Matsugami et al.   NUCLEIC ACIDS RESEARCH