Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2

Lignans and Their Derivatives from Plants as Antivirals

(2020) Qinghua Cui et al.   MOLECULES

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Emergence of Novel Coronavirus and COVID-19: whether to stay or die out?

(2020) Asim Biswas et al.   CRITICAL REVIEWS IN MICROBIOLOGY

ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective

(2020) Andrew M. South et al.   HYPERTENSION

Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19

(2020) Pan Luo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A computational prediction of SARS-CoV-2 structural protein inhibitors from Azadirachta indica (Neem)

(2020) Subhomoi Borkotoky et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations

(2020) I. Aanouz et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In-silico approaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel

(2020) Manoj Kumar Gupta et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target

(2020) Umesh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

(2020) Sukanth Kumar Enmozhi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In-silico homology assisted identification of inhibitor of RNA binding against 2019-nCoV N-protein (N terminal domain)

(2020) Phulen Sarma et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies

(2020) Sanjay Gupta et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Genotype and phenotype of COVID-19: Their roles in pathogenesis

(2020) Leila Mousavizadeh et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

A review of South Indian medicinal plant has the ability to combat against deadly viruses along with COVID-19?

(2020) Mani Divya et al.   MICROBIAL PATHOGENESIS

Potential effects of curcumin in the treatment of COVID ‐19 infection

(2020) Fatemeh Zahedipour et al.   PHYTOTHERAPY RESEARCH

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

(2020) Liang Chen et al.   Nutrients

COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics

(2020) Kuldeep Dhama et al.   Human Vaccines & Immunotherapeutics

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

(2020) Ya-Nan Zhang et al.   Emerging Microbes & Infections

Traditional Chinese Medicine treatment of COVID-19

(2020) Jia Xu et al.   Complementary Therapies in Clinical Practice

Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection?

(2020) Harald Murck   Frontiers in Immunology

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil

(2020) Bui Thi Phuong Thuy et al.   ACS Omega

Potential use of turmeric in COVID‐19

(2020) H. Gupta et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Coronavirus Disease 2019–COVID-19

(2020) Kuldeep Dhama et al.   CLINICAL MICROBIOLOGY REVIEWS

Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach

(2020) Rupesh V. Chikhale et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor

(2020) Manish Kumar Tripathi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification of bioactive compounds from Glycyrrhiza glabra as possible inhibitor of SARS-CoV-2 spike glycoprotein and non-structural protein-15: a pharmacoinformatics study

(2020) Saurabh K. Sinha et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

nCOV-19 peptides mass fingerprinting identification, binding, and blocking of inhibitors flavonoids and anthraquinone of Moringa oleifera and hydroxychloroquine

(2020) Muhammad Hamza et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Screening of phytochemical compounds of Tinospora cordifolia for their inhibitory activity on SARS-CoV-2: an in silico study

(2020) S. Krupanidhi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds in drug trials

(2020) Natarajan Arul Murugan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors – an in silico docking and molecular dynamics simulation study

(2020) Rajesh Ghosh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19

(2020) Andrea Cortegiani et al.   JOURNAL OF CRITICAL CARE

Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 Mpro enzyme through in silico approach

(2020) Arun Bahadur Gurung et al.   LIFE SCIENCES

Purposing Saikosaponins for the treatment of COVID-19

(2020) Eshak I. Bahbah et al.   MEDICAL HYPOTHESES

Potential of Flavonoid-Inspired Phytomedicines against COVID-19

(2020) Wilfred Ngwa et al.   MOLECULES

COVID-19: A promising cure for the global panic

(2020) Balachandar Vellingiri et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

(2020) Janice S. Mani et al.   VIRUS RESEARCH

Withaferin A: a potential therapeutic agent against COVID-19 infection

(2020) Alex R. Straughn et al.   Journal of Ovarian Research

COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines

(2020) Mohd. Iqbal Yatoo et al.   Human Vaccines & Immunotherapeutics

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

(2020) Ruben Manuel Luciano Colunga Biancatelli et al.   Frontiers in Immunology

Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients

(2020) Joaquim Bosch-Barrera et al.   Journal of Clinical Medicine

Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective

(2020) Yashpal Singh Malik et al.   Pathogens

Roles of flavonoids against coronavirus infection

(2020) Maria Russo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

(2020) Christian Bailly et al.   PHARMACOLOGY & THERAPEUTICS

COVID-19 pandemic: A pragmatic plan for ayurveda intervention

(2020) Sanjeev Rastogi et al.   Journal of Ayurveda and Integrative Medicine

High-throughput Screening and Identification of Potent Broad-spectrum Inhibitors of Coronaviruses

(2019) Liang Shen et al.   JOURNAL OF VIROLOGY

Antiviral activity of sophoridine against enterovirus 71 in vitro

(2019) Gang Ren et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antiviral Activities of Silymarin and Derivatives

(2019) Ching-Hsuan Liu et al.   MOLECULES

Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 Activities In Vitro and In Vivo

(2019) Guangyong Ma et al.   JOURNAL OF VIROLOGY

Veronica Plants—Drifting from Farm to Traditional Healing, Food Application, and Phytopharmacology

(2019) Bahare Salehi et al.   MOLECULES

An ethnobotanical study of medicinal plants used to treat skin diseases in northern Pakistan

(2019) Khafsa Malik et al.   BMC Complementary and Alternative Medicine

New strategy for identifying potential natural HIV-1 non-nucleoside reverse transcriptase inhibitors against drug-resistance: an in silico study

(2019) Yanjing Wang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

(2019) Alicia Martinez-Lopez et al.   EBioMedicine

Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

(2018) Minakshi Prasad et al.   BIOMEDICINE & PHARMACOTHERAPY

Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

(2018) Ruchi Tiwari et al.   CURRENT DRUG METABOLISM

Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects

(2018) Kuldeep Dhama et al.   CURRENT DRUG METABOLISM

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

(2018) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of diphyllin as a novel V-ATPase inhibitor on TE-1 and ECA-109 cells

(2018) Haijiao Chen et al.   ONCOLOGY REPORTS

In vitro antiviral activity of twenty-seven medicinal plant extracts from Southwest Nigeria against three serotypes of echoviruses

(2018) Omonike O. Ogbole et al.   Virology Journal

The structural model of Zika virus RNA-dependent RNA polymerase in complex with RNA for rational design of novel nucleotide inhibitors

(2018) Jakub Šebera et al.   Scientific Reports

Advances in Designing and Developing Vaccines, Drugs, and Therapies to Counter Ebola Virus

(2018) Kuldeep Dhama et al.   Frontiers in Immunology

Nutritional and Pharmaceutical Applications of Nanotechnology: Trends and Advances

(2017) Mohamed Ezzat Abd et al.   International Journal of Pharmacology

Anti-HIV diphyllin glycosides from Justicia gendarussa

(2017) Hong-Jie Zhang et al.   PHYTOCHEMISTRY

Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs

(2017) Hai Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chikungunya Virus: Pathophysiology, Mechanism, and Modeling

(2017) Vaishnavi Ganesan et al.   Viruses-Basel

Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives

(2017) Ashok Munjal et al.   Frontiers in Microbiology

Apigenin inhibits African swine fever virus infection in vitro

(2016) Astghik Hakobyan et al.   ARCHIVES OF VIROLOGY

Therapeutics Role ofAzadirachta indica(Neem) and Their Active Constituents in Diseases Prevention and Treatment

(2016) Mohammad A. Alzohairy   Evidence-based Complementary and Alternative Medicine

Recent advances in research on lignans and neolignans

(2016) Rémy Bertrand Teponno et al.   NATURAL PRODUCT REPORTS

Activity of compounds from Taxillus sutchuenensis as inhibitors of HCV NS3 serine protease

(2016) Liyuan Yang et al.   NATURAL PRODUCT RESEARCH

Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/−9 and heparanase in MDA-MB-231 cells

(2016) Chenghua Lou et al.   ONCOLOGY REPORTS

Antiviral activity of luteolin against Japanese encephalitis virus

(2016) Wenchun Fan et al.   VIRUS RESEARCH

Critical review of resveratrol in xenobiotic-induced hepatotoxicity

(2015) Mitchell R. McGill et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti—chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon

(2015) Krishnan Saravana Murali et al.   Asian Pacific Journal of Tropical Medicine

Activity of andrographolide against chikungunya virus infection

(2015) Phitchayapak Wintachai et al.   Scientific Reports

Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

(2015) Ming Chu et al.   Biomed Research International

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Ellagitannins as synergists of ACV on the replication of ACV-resistant strains of HSV 1 and 2

(2014) N. Vilhelmova-Ilieva et al.   ANTIVIRAL RESEARCH

Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway

(2014) Xiaowen Lv et al.   ANTIVIRAL RESEARCH

Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus

(2014) Rubén Soto-Acosta et al.   ANTIVIRAL RESEARCH

In vitro and in vivo anti-hepatitis B virus activities of the lignan niranthin isolated from Phyllanthus niruri L.

(2014) Sheng Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Kaempferol Derivatives as Antiviral Drugs against the 3a Channel Protein of Coronavirus

(2014) Silvia Schwarz et al.   PLANTA MEDICA

Apigenin Inhibits Enterovirus-71 Infection by Disrupting Viral RNA Association with trans-Acting Factors

(2014) Wei Zhang et al.   PLoS One

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels

(2014) Chikako Shibata et al.   VIROLOGY

Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening

(2014) Lin Xu et al.   Viruses-Basel

Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses

(2013) Hui-Wen Chen et al.   ANTIVIRAL RESEARCH

Evaluation of Antiviral Activities of Four Local Malaysian Phyllanthus Species against Herpes Simplex Viruses and Possible Antiviral Target

(2013) Wee Chee Tan et al.   International Journal of Medical Sciences

Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro

(2013) ZIFENG YANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Quercetin inhibits rhinovirus replication in vitro and in vivo

(2012) Shyamala Ganesan et al.   ANTIVIRAL RESEARCH

Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells

(2012) Patchima Sithisarn et al.   ANTIVIRAL RESEARCH

Anti- Japanese-Encephalitis-Viral Effects of Kaempferol and Daidzin and Their RNA-Binding Characteristics

(2012) Ting Zhang et al.   PLoS One

An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts

(2012) Karen Knipping et al.   Virology Journal

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio

Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase

(2011) Jie Dou et al.   ARCHIVES OF VIROLOGY

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

(2011) Abhinav Grover et al.   BMC BIOINFORMATICS

Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus

(2011) Gulam H. Syed et al.   HEPATOLOGY

Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity

(2011) L. Bachmetov et al.   JOURNAL OF VIRAL HEPATITIS

Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral Glycoprotein-Glycosaminoglycan Interactions To Inhibit Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread

(2011) L.-T. Lin et al.   JOURNAL OF VIROLOGY

Silymarin efficacy against influenza A virus replication

(2011) J.H. Song et al.   PHYTOMEDICINE

Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression

(2011) Martin Michaelis et al.   PLoS One

A Flavonoid, Luteolin, Cripples HIV-1 by Abrogation of Tat Function

(2011) Rajeev Mehla et al.   PLoS One

Antiviral activity of four types of bioflavonoid against dengue virus type-2

(2011) Keivan Zandi et al.   Virology Journal

Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid

(2010) Justin J. Pollara et al.   ANTIVIRAL RESEARCH

Three-dimensional analysis of combination effect of ellagitannins and acyclovir on herpes simplex virus types 1 and 2

(2010) N. Vilhelmova et al.   ANTIVIRAL RESEARCH

Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus

(2010) Kyoko Hayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibitory Effects of Baicalein on the Influenza Virus in Vivo Is Determined by Baicalin in the Serum

(2010) Ge Xu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Influenza Virus–Cytokine‐Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza

(2010) Siye Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-κB-dependent transcription of TNF-α and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA

(2010) Akinbolade O Oyegunwa et al.   Journal of Inflammation-London

HIV virology and pathogenetic mechanisms of infection: a brief overview

(2010) Emanuele Fanales-Belasio et al.   ANNALI DELL ISTITUTO SUPERIORE DI SANITA

Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities

(2009) Hyung Jae Jeong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Polysaccharides from Padina tetrastromatica: Structural features, chemical modification and antiviral activity

(2009) Paramita Karmakar et al.   CARBOHYDRATE POLYMERS

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production

(2009) Oscar Gonzalez et al.   HEPATOLOGY

Soy isoflavones and virus infections

(2009) Aline Andres et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Bicyclol: A Novel Drug for Treating Chronic Viral Hepatitis B and C

(2009) Geng Liu   Medicinal Chemistry

Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice

(2009) Alexandre P. Rogerio et al.   PHARMACOLOGICAL RESEARCH

Epigallocatechin Gallate Inactivates Clinical Isolates of Herpes Simplex Virus

(2008) C. E. Isaacs et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anti-Influenza Virus Activities of Flavonoids from the Medicinal PlantElsholtzia rugulosa

(2008) Ai-Lin Liu et al.   PLANTA MEDICA

Antiviral effects ofGlycyrrhiza species

(2007) Cristina Fiore et al.   PHYTOTHERAPY RESEARCH