Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit

Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice

(2020) Ying Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure

(2019) Xiangyang Xie et al.   Cell Metabolism

AGRP neurons modulate fasting-induced anxiolytic effects

(2019) Changhong Li et al.   Translational Psychiatry

New Neuroscience of Homeostasis and Drives for Food, Water, and Salt

(2019) Bradford B. Lowell   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

(2019) Jonathan Cedernaes et al.   Cell Metabolism

Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity

(2019) Joshua D. Welch et al.   CELL

5-HT3 Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface

(2019) Gohar Fakhfouri et al.   PHARMACOLOGICAL REVIEWS

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding

(2019) Mark A. Rossi et al.   SCIENCE

A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding

(2019) Yong Wang et al.   Nature Communications

CNS-targeting pharmacological interventions for the metabolic syndrome

(2019) Kerstin Stemmer et al.   JOURNAL OF CLINICAL INVESTIGATION

Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

(2019) Breno S. Diniz et al.   Translational Psychiatry

Integrated pathways that control stress and energy homeostasis

(2019) Herbert Herzog   Nature Reviews Endocrinology

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

(2019) Zachary J. Ward et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Neural Circuit for the Suppression of Pain by a Competing Need State

(2018) Amber L. Alhadeff et al.   CELL

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

(2018) Marion Soto et al.   MOLECULAR PSYCHIATRY

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms

(2017) Hans-Rudolf Berthoud et al.   GASTROENTEROLOGY

Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner

(2017) A L Garcia-Garcia et al.   MOLECULAR PSYCHIATRY

Reversing behavioural abnormalities in mice exposed to maternal inflammation

(2017) Yeong Shin Yim et al.   NATURE

Homeostatic circuits selectively gate food cue responses in insular cortex

(2017) Yoav Livneh et al.   NATURE

Mechanisms, Pathophysiology, and Management of Obesity

(2017) Steven B. Heymsfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

AgRP to Kiss1 neuron signaling links nutritional state and fertility

(2017) Stephanie L. Padilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH

(2016) Erica J P Anderson et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior

(2016) C M Mazzone et al.   MOLECULAR PSYCHIATRY

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

(2016) M A Lebow et al.   MOLECULAR PSYCHIATRY

Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala

(2016) Catherine A. Marcinkiewcz et al.   NATURE

Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state

(2016) Stephanie L Padilla et al.   NATURE NEUROSCIENCE

Hunger-Driven Motivational State Competition

(2016) C. Joseph Burnett et al.   NEURON

New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism

(2016) Fantao Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism

(2016) Yanlin He et al.   Cell Reports

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding

(2015) Marcelo O. Dietrich et al.   CELL

The Hunger Genes: Pathways to Obesity

(2015) Agatha A. van der Klaauw et al.   CELL

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses

(2015) E. M. Callaway et al.   JOURNAL OF NEUROSCIENCE

High fat diet attenuates glucose-dependent facilitation of 5-HT3-mediated responses in rat gastric vagal afferents

(2015) Amanda E. Troy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activating positive memory engrams suppresses depression-like behaviour

(2015) Steve Ramirez et al.   NATURE

Neurons for hunger and thirst transmit a negative-valence teaching signal

(2015) J. Nicholas Betley et al.   NATURE

A neural basis for melanocortin-4 receptor–regulated appetite

(2015) Alastair S Garfield et al.   NATURE NEUROSCIENCE

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Circuits Controlling Energy Balance and Mood: Inherently Intertwined or Just Complicated Intersections?

(2014) Chen Liu et al.   Cell Metabolism

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in Control of Autonomic and Neuroendocrine Functions: A Review

(2013) Carlos Crestani et al.   Current Neuropharmacology

Zonisamide for Weight Reduction in Obese Adults

(2012) Kishore M. Gadde et al.   ARCHIVES OF INTERNAL MEDICINE

Deciphering a neuronal circuit that mediates appetite

(2012) Qi Wu et al.   NATURE

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons

(2012) Marcelo O. Dietrich et al.   NATURE REVIEWS DRUG DISCOVERY

Cell-type specific deletion of GABA(A) 1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction

(2012) G. M. Gafford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

(2011) Qi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice

(2009) S Weber et al.   INTERNATIONAL JOURNAL OF OBESITY

Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons

(2009) A. N. van den Pol et al.   JOURNAL OF NEUROSCIENCE

The response of neurons in the bed nucleus of the stria terminalis to serotonin: Implications for anxiety

(2009) Sayamwong E. Hammack et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The impact of zonisamide on weight. A clinical study in 103 patients with epilepsy

(2008) J. Wellmer et al.   ACTA NEUROLOGICA SCANDINAVICA

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Zonisamide Prevents Olanzapine-Associated Hyperphagia, Weight Gain and Elevated Blood Glucose in Rats

(2008) Nicholas M Wallingford et al.   NEUROPSYCHOPHARMACOLOGY