60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH

The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

(2016) Anna L Chaly et al.   eLife

Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System

(2015) Matthew A. Nix et al.   BIOPHYSICAL JOURNAL

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding

(2015) Marcelo O. Dietrich et al.   CELL

A Stereological Analysis of NPY, POMC, Orexin, GFAP Astrocyte, and Iba1 Microglia Cell Number and Volume in Diet-Induced Obese Male Mice

(2015) Moyra B. Lemus et al.   ENDOCRINOLOGY

RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

(2015) Kong Y. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade

(2015) K. G. Mountjoy   JOURNAL OF NEUROENDOCRINOLOGY

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Neurons for hunger and thirst transmit a negative-valence teaching signal

(2015) J. Nicholas Betley et al.   NATURE

A neural basis for melanocortin-4 receptor–regulated appetite

(2015) Alastair S Garfield et al.   NATURE NEUROSCIENCE

Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons

(2015) Daqing Wang et al.   Frontiers in Neuroanatomy

Chemogenetic Tools to Interrogate Brain Functions

(2014) Scott M. Sternson et al.   Annual Review of Neuroscience

The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo

(2014) Brandon L. Panaro et al.   Cell Metabolism

Gender-Specific Roles for the Melanocortin-3 Receptor in the Regulation of the Mesolimbic Dopamine System in Mice

(2014) Rachel N. Lippert et al.   ENDOCRINOLOGY

Evolution of the melanocortin system

(2014) Raúl Cortés et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The Angiotensin II Type 1 Receptor (AT1R) Closely Interacts with Large Conductance Voltage- and Ca2+-activated K+(BK) Channels and Inhibits Their Activity Independent of G-protein Activation

(2014) Zhu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Food Intake and Energy Expenditure by Nos1 Neurons of the Paraventricular Hypothalamus

(2014) A. K. Sutton et al.   JOURNAL OF NEUROSCIENCE

Synaptic changes induced by melanocortin signalling

(2014) Vanni Caruso et al.   NATURE REVIEWS NEUROSCIENCE

MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

(2014) B. P. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

Molecular and Functional Analysis of Human β-Defensin 3 Action at Melanocortin Receptors

(2013) Matthew A. Nix et al.   CHEMISTRY & BIOLOGY

hMRAPa increases αMSH-induced hMC1R and hMC3R functional coupling and hMC4R constitutive activity

(2013) Emma I Kay et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Neonatal Leptin Exposure Specifies Innervation of Presympathetic Hypothalamic Neurons and Improves the Metabolic Status of Leptin-Deficient Mice

(2013) K. Bouyer et al.   JOURNAL OF NEUROSCIENCE

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

(2013) J. A. Sebag et al.   SCIENCE

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

(2013) M. Asai et al.   SCIENCE

Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

(2012) P. Kievit et al.   DIABETES

Melanocortin 4 receptor distribution in the human hypothalamus

(2012) Jacqueline E Siljee et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area

(2012) Huxing Cui et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Defining MC1R Regulation in Human Melanocytes by Its Agonist α-Melanocortin and Antagonists Agouti Signaling Protein and β-Defensin 3

(2012) Viki B. Swope et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Deconstruction of a neural circuit for hunger

(2012) Deniz Atasoy et al.   NATURE

Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands

(2012) Kimberley A. Beaumont et al.   Pigment Cell & Melanoma Research

An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure

(2012) Zhaofei Wu et al.   PLoS One

Melanocortin-3 receptor regulates the normal fasting response

(2012) B. J. Renquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency

(2011) Marcus P. Corander et al.   ENDOCRINOLOGY

Defining POMC Neurons Using Transgenic Reagents: Impact of TransientPomcExpression in Diverse Immature Neuronal Populations

(2011) Stephanie L. Padilla et al.   ENDOCRINOLOGY

The early origin of melanocortin receptors, agouti-related peptide, agouti signalling peptide, and melanocortin receptor-accessory proteins, with emphasis on pufferfishes, elephant shark, lampreys, and amphioxus

(2011) Åke Västermark et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

(2011) Qi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MahoganoidandMahoganyMutations Rectify the Obesity of the Yellow Mouse by Effects on Endosomal Traffic of MC4R Protein

(2011) John D. Overton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis

(2011) Karima Begriche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Regulation of Thyrotropin-Releasing Hormone-Expressing Neurons in Paraventricular Nucleus of the Hypothalamus by Signals of Adiposity

(2010) Masoud Ghamari-Langroudi et al.   MOLECULAR ENDOCRINOLOGY

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice

(2010) Q. Zheng et al.   NEUROSCIENCE

Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin

(2010) M. Ghamari-Langroudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration

(2009) Jian Jiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions

(2009) Laurent Gautron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

(2009) L. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

(2009) H.-C. Tsai et al.   SCIENCE

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

Ablation of Neurons Expressing Agouti-Related Protein Activates Fos and Gliosis in Postsynaptic Target Regions

(2008) Q. Wu et al.   JOURNAL OF NEUROSCIENCE

Starvation after AgRP neuron ablation is independent of melanocortin signaling

(2008) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY