New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

(2016) Ken-ichiro Nakajima et al.   Nature Communications

Palatability Can Drive Feeding Independent of AgRP Neurons

(2015) Raphaël G.P. Denis et al.   Cell Metabolism

Therapeutics Based on Stop Codon Readthrough

(2014) Kim M. Keeling et al.   Annual Review of Genomics and Human Genetics

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat

(2014) Hai-Bin Ruan et al.   CELL

Mouse Insulin Cells Expressing an Inducible RIPCre Transgene Are Functionally Impaired

(2014) Gladys Teitelman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

When proteins start to make sense: fine-tuning of aminoglycosides for PTC suppression therapy

(2014) Moran Shalev et al.   MedChemComm

Pancreas-Specific Cre Driver Lines and Considerations for Their Prudent Use

(2013) Mark A. Magnuson et al.   Cell Metabolism

Metabolic Pitfalls of CNS Cre-Based Technology

(2013) Erika Harno et al.   Cell Metabolism

Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver

(2013) J. Lexow et al.   Disease Models & Mechanisms

Genetic identification of a neural circuit that suppresses appetite

(2013) Matthew E. Carter et al.   NATURE

NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus

(2013) Qi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal circuits that regulate feeding behavior and metabolism

(2013) Jong-Woo Sohn et al.   TRENDS IN NEUROSCIENCES

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

Increased Selectivity toward Cytoplasmic versus Mitochondrial Ribosome Confers Improved Efficiency of Synthetic Aminoglycosides in Fixing Damaged Genes: A Strategy for Treatment of Genetic Diseases Caused by Nonsense Mutations

(2012) Jeyakumar Kandasamy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering a neuronal circuit that mediates appetite

(2012) Qi Wu et al.   NATURE

NMD: a multifaceted response to premature translational termination

(2012) Stephanie Kervestin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility

(2012) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sense from nonsense: therapies for premature stop codon diseases

(2012) Laure Bidou et al.   TRENDS IN MOLECULAR MEDICINE

Aging and Peptide Control of Food Intake

(2011) Zbigniew Kmiec   CURRENT PROTEIN & PEPTIDE SCIENCE

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

(2011) Qi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of “floxed” alleles

(2010) Won Jae Huh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Repairing faulty genes by aminoglycosides: Development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations

(2010) Igor Nudelman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

Aminoglycoside-induced mutation suppression (stop codon readthrough) as a therapeutic strategy for Duchenne muscular dystrophy

(2010) Vinod Malik et al.   Therapeutic Advances in Neurological Disorders

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

A meta-analysis of nonsense mutations causing human genetic disease

(2008) Matthew Mort et al.   HUMAN MUTATION

Ablation of Neurons Expressing Agouti-Related Protein Activates Fos and Gliosis in Postsynaptic Target Regions

(2008) Q. Wu et al.   JOURNAL OF NEUROSCIENCE

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Starvation after AgRP neuron ablation is independent of melanocortin signaling

(2008) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA