Lumican negatively controls the pathogenicity of murine encephalitic TH17 cells

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

TNF-α–stimulated fibroblasts secrete lumican to promote fibrocyte differentiation

(2015) Darrell Pilling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

(2014) T. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Lumican Binds ALK5 to Promote Epithelium Wound Healing

(2013) Osamu Yamanaka et al.   PLoS One

Therapies for multiple sclerosis: translational achievements and outstanding needs

(2013) Aiden Haghikia et al.   TRENDS IN MOLECULAR MEDICINE

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation

(2012) Peter J. Darlington et al.   ANNALS OF NEUROLOGY

An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS

(2012) Naoto Kawakami et al.   IMMUNOLOGICAL REVIEWS

Extracellular Matrix Lumican Promotes Bacterial Phagocytosis, andLum−/−Mice Show IncreasedPseudomonas aeruginosaLung Infection Severity

(2012) HanJuan Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis

(2011) F. Jadidi-Niaragh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Lumican inhibits angiogenesis by interfering with α2β1 receptor activity and downregulating MMP-14 expression

(2011) Jolanta Niewiarowska et al.   THROMBOSIS RESEARCH

Act1, Scene Brain: Astrocytes Play a Lead Role

(2010) Jane M. Rodgers et al.   IMMUNITY

Lumican is required for neutrophil extravasation following corneal injury and wound healing

(2010) Y. Hayashi et al.   JOURNAL OF CELL SCIENCE

Current Views on the Roles of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Mohamed El-behi et al.   Journal of Neuroimmune Pharmacology

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Regulation and Function of Proinflammatory TH17 Cells

(2009) Gustavo J. Martinez et al.   Annals of the New York Academy of Sciences

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

Extracellular Matrix Lumican Deposited on the Surface of Neutrophils Promotes Migration by Binding to β2Integrin

(2009) Seakwoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

(2009) Yuhong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response

(2009) A. Liston et al.   JOURNAL OF IMMUNOLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Lumican, a small leucine-rich proteoglycan

(2008) Dragana Nikitovic et al.   IUBMB LIFE

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of β1 integrin as mediator of melanoma cell adhesion to lumican

(2007) Marie-France D’Onofrio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS