Insulin action on astrocytes: From energy homeostasis to behaviour

Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal

(2020) Danaé Nuzzaci et al.   Cell Reports

Brain insulin sensitivity is linked to adiposity and body fat distribution

(2020) Stephanie Kullmann et al.   Nature Communications

Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation

(2020) Lauren M. Stein et al.   Translational Psychiatry

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus

(2020) Clarissa Branco Haas et al.   BRAIN RESEARCH

Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin

(2020) Florent Guillebaud et al.   MOLECULAR NEUROBIOLOGY

Astroglia-specific contributions to the regulation of synapses, cognition and behaviour

(2020) Marcus Augusto-Oliveira et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia

(2020) Suzanne Craft et al.   JAMA Neurology

Central nervous pathways of insulin action in the control of metabolism and food intake

(2020) Stephanie Kullmann et al.   Lancet Diabetes & Endocrinology

Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation

(2020) Iyad H Manaserh et al.   JOURNAL OF ENDOCRINOLOGY

Inhibition of mitochondrial fission and iNOS in the dorsal vagal complex protects from overeating and weight gain

(2020) Bianca Patel et al.   Molecular Metabolism

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain

(2019) Kristina Wardelmann et al.   Molecular Metabolism

Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice

(2019) Iyad H. Manaserh et al.   PLOS BIOLOGY

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

(2019) Marion Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionic signalling in astroglia beyond calcium

(2019) Alexei Verkhratsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system

(2019) Khalil Bouyakdan et al.   JOURNAL OF CLINICAL INVESTIGATION

Comorbid elevated symptoms of anxiety and depression in adults with type 1 or type 2 diabetes: Results from the International Diabetes MILES Study

(2019) Giesje Nefs et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem

(2019) Miae Jang et al.   eLife

Astrocytes: From the Physiology to the Disease

(2019) Laura Trujillo-Estrada et al.   Current Alzheimer Research

Evidence that hindbrain astrocytes in the rat detect low glucose with a glucose transporter 2-phospholipase C-calcium release mechanism

(2019) Richard C. Rogers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Na+-dependent transporters: The backbone of astroglial homeostatic function

(2019) Alexei Verkhratsky et al.   CELL CALCIUM

Regulation of food intake by astrocytes in the brainstem dorsal vagal complex

(2019) Alastair J. MacDonald et al.   GLIA

Response of catecholaminergic neurons in the mouse hindbrain to glucoprivic stimuli is astrocyte dependent

(2018) Richard C. Rogers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Insulin regulates astrocyte gliotransmission and modulates behavior

(2018) Weikang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

The effects of insulin on the inflammatory activity of BV2 microglia

(2018) Fiona Brabazon et al.   PLoS One

Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice

(2018) Erin R. Hascup et al.   JOURNAL OF NEUROCHEMISTRY

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

(2018) Cristina García-Cáceres et al.   NATURE NEUROSCIENCE

Insulin suppresses MPP+-induced neurotoxicity by targeting integrins and syndecans in C6 astrocytes

(2017) Mahesh Ramalingam et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

(2017) Jason Pitt et al.   MOLECULAR BIOLOGY OF THE CELL

How does sex matter? Behavior, stress and animal models of neurobehavioral disorders

(2017) Paola Palanza et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Insulin resistance in Alzheimer's disease

(2017) Thomas Diehl et al.   Translational Research

Corrigendum to “Insulin controls food intake and energy balance via NPY neurons” [Mol Metabol 6 (2017) 574–584]

(2017) Kim Loh et al.   Molecular Metabolism

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

The insulin-like growth factor I receptor regulates glucose transport by astrocytes

(2016) Edwin Hernandez-Garzón et al.   GLIA

Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance

(2016) D. J. Reiner et al.   JOURNAL OF NEUROSCIENCE

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

(2016) Naiyan Chen et al.   eLife

Insulin Modulates In Vitro Secretion of Cytokines and Cytotoxins by Human Glial Cells

(2015) Lindsay Spielman et al.   Current Alzheimer Research

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

(2015) Liang Yang et al.   Cell Reports

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

(2015) Claire J. Garwood et al.   Molecular Brain

The link between depression and diabetes: the search for shared mechanisms

(2015) Calum D Moulton et al.   Lancet Diabetes & Endocrinology

Diabetes Mellitus and Dementia

(2014) Toshiharu Ninomiya   Current Diabetes Reports

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin

(2014) N. Rajasekar et al.   NEUROPHARMACOLOGY

Astroglial cradle in the life of the synapse

(2014) A. Verkhratsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Hypothalamic Astroglial Connexins are Required for Brain Glucose Sensing-Induced Insulin Secretion

(2013) Camille Allard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cooperation between brain and islet in glucose homeostasis and diabetes

(2013) Michael W. Schwartz et al.   NATURE

Astrocytes in the nucleus of the solitary tract are activated by low glucose or glucoprivation: evidence for glial involvement in glucose homeostasis

(2013) David H. McDougal et al.   Frontiers in Neuroscience

Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

(2012) G. Musen et al.   DIABETES

Artifact versus reality-How astrocytes contribute to synaptic events

(2012) Maiken Nedergaard et al.   GLIA

Diabetes and cognitive dysfunction

(2012) Rory J McCrimmon et al.   LANCET

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia

(2011) N. R. Bolo et al.   DIABETES

Glucose Transporter-1 in the Hypothalamic Glial Cells Mediates Glucose Sensing to Regulate Glucose Production In Vivo

(2011) M. Chari et al.   DIABETES

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Neuron–astrocyte communication and synaptic plasticity

(2010) Sónia Paixão et al.   CURRENT OPINION IN NEUROBIOLOGY

Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes

(2010) Hong Zhou et al.   NEUROSCIENCE LETTERS

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cognition and diabetes: a lifespan perspective

(2008) Geert Jan Biessels et al.   LANCET NEUROLOGY