Sensitivity and Uncertainty Analysis of Two Human Atrial Cardiac Cell Models Using Gaussian Process Emulators

Why so many published sensitivity analyses are false: A systematic review of sensitivity analysis practices

(2019) Andrea Saltelli et al.   ENVIRONMENTAL MODELLING & SOFTWARE

Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models

(2019) Pras Pathmanathan et al.   Frontiers in Physiology

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

(2018) Kylie A. Beattie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fitting two human atrial cell models to experimental data using Bayesian history matching

(2018) Sam Coveney et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation

(2018) Brodie A. Lawson et al.   Frontiers in Physiology

Bayesian sensitivity analysis of a 1D vascular model with Gaussian process emulators

(2017) Alessandro Melis et al.   International Journal for Numerical Methods in Biomedical Engineering

Quantifying the effect of uncertainty in input parameters in a simplified bidomain model of partial thickness ischaemia

(2017) Barbara M. Johnston et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

(2016) Ross H. Johnstone et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Uncertainty and variability in computational and mathematical models of cardiac physiology

(2016) Gary R. Mirams et al.   JOURNAL OF PHYSIOLOGY-LONDON

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

(2016) Marta Varela et al.   PLoS Computational Biology

A guide to uncertainty quantification and sensitivity analysis for cardiovascular applications

(2015) Vinzenz Gregor Eck et al.   International Journal for Numerical Methods in Biomedical Engineering

Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology

(2015) Pras Pathmanathan et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Bayesian Sensitivity Analysis of a Cardiac Cell Model Using a Gaussian Process Emulator

(2015) Eugene T Y Chang et al.   PLoS One

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

(2014) Carlos Sánchez et al.   PLoS One

In Silico Screening of the Key Cellular Remodeling Targets in Chronic Atrial Fibrillation

(2014) Jussi T. Koivumäki et al.   PLoS Computational Biology

Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria

(2013) Michael A. Colman et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Three-Dimensional Human Atrial Model with Fiber Orientation. Electrograms and Arrhythmic Activation Patterns Relationship

(2013) Catalina Tobón et al.   PLoS One

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benchmarking electrophysiological models of human atrial myocytes

(2013) Mathias Wilhelms et al.   Frontiers in Physiology

Nonlinear Dynamics in Cardiology

(2012) Trine Krogh-Madsen et al.   Annual Review of Biomedical Engineering

Update 1 of: Sensitivity Analysis for Chemical Models

(2012) Andrea Saltelli et al.   CHEMICAL REVIEWS

The effect of the nugget on Gaussian process emulators of computer models

(2012) Ioannis Andrianakis et al.   COMPUTATIONAL STATISTICS & DATA ANALYSIS

Exploiting mathematical models to illuminate electrophysiological variability between individuals

(2012) Amrita X. Sarkar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study

(2012) Trine Krogh-Madsen et al.   PLoS Computational Biology

Susceptibility to Arrhythmia in the Infarcted Heart Depends on Myofibroblast Density

(2011) Kathleen S. McDowell et al.   BIOPHYSICAL JOURNAL

Human Atrial Action Potential and Ca 2+ Model

(2011) Eleonora Grandi et al.   CIRCULATION RESEARCH

Models of cardiac tissue electrophysiology: Progress, challenges and open questions

(2010) R.H. Clayton et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

(2010) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

(2010) Amrita X. Sarkar et al.   PLoS Computational Biology

K+ current changes account for the rate dependence of the action potential in the human atrial myocyte

(2009) Mary M. Maleckar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gaussian process emulation of dynamic computer codes

(2009) S. Conti et al.   BIOMETRIKA

Orthogonal and nearly orthogonal designs for computer experiments

(2009) D. Bingham et al.   BIOMETRIKA

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

A meta-analysis of cardiac electrophysiology computational models

(2009) S. A. Niederer et al.   EXPERIMENTAL PHYSIOLOGY

Bayesian emulation of complex multi-output and dynamic computer models

(2009) Stefano Conti et al.   JOURNAL OF STATISTICAL PLANNING AND INFERENCE

Properties of two human atrial cell models in tissue: Restitution, memory, propagation, and reentry

(2008) Elizabeth M. Cherry et al.   JOURNAL OF THEORETICAL BIOLOGY

Dynamics of human atrial cell models: Restitution, memory, and intracellular calcium dynamics in single cells

(2008) Elizabeth M. Cherry et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY