Pharmacological Targeting of Executioner Proteins: Controlling Life and Death

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

(2020) Tomomi Kuwana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

(2020) Christian Bogner et al.   MOLECULAR CELL

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

(2020) Daniel T. Cohen et al.   Cell Reports

Characterization of an alternative BAK-binding site for BH3 peptides

(2020) Kaiqin Ye et al.   Nature Communications

Small-molecule allosteric inhibitors of BAX

(2019) Thomas P. Garner et al.   Nature Chemical Biology

Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia

(2019) Eugen Tausch et al.   HAEMATOLOGICA

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

(2019) Michael A. Dengler et al.   Cell Reports

Completion of BAX recruitment correlates with mitochondrial fission during apoptosis

(2019) M. E. Maes et al.   Scientific Reports

Correction for Cong et al., “Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax”

(2018) Haolong Cong et al.   JOURNAL OF VIROLOGY

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis

(2018) Janet H. Zheng et al.   Cell Reports

Cheating death for a better transplant

(2018) Sehar Afreen et al.   STEM CELLS

Ensemble Properties of Bax Determine Its Function

(2018) Adeline Y. Robin et al.   STRUCTURE

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

(2018) Courtney D. DiNardo et al.   BLOOD

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID

(2017) Yuniel Fernández-Marrero et al.   FEBS Journal

Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation

(2017) Matthias Kollek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathways and mechanisms of venetoclax resistance

(2017) Prithviraj Bose et al.   LEUKEMIA & LYMPHOMA

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

(2017) Jason M. Brouwer et al.   MOLECULAR CELL

Allosteric sensitization of proapoptotic BAX

(2017) Jonathan R Pritz et al.   Nature Chemical Biology

Bax and Bak Pores: Are We Closing the Circle?

(2017) Katia Cosentino et al.   TRENDS IN CELL BIOLOGY

The Bcl-2 Family in Host-Virus Interactions

(2017) Marc Kvansakul et al.   Viruses-Basel

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes

(2017) Liqun Zhao et al.   Scientific Reports

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

(2016) Giuseppa Pistritto et al.   Aging-US

Small molecules reveal an alternative mechanism of Bax activation

(2016) H. Brahmbhatt et al.   BIOCHEMICAL JOURNAL

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

(2016) Thomas P. Garner et al.   MOLECULAR CELL

Cardiovascular Toxic Effects of Targeted Cancer Therapies

(2016) Javid J. Moslehi   NEW ENGLAND JOURNAL OF MEDICINE

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

(2016) Sweta Iyer et al.   Nature Communications

Structure-Based Lead Optimization and Biological Evaluation of BAX Direct Activators as Novel Potential Anticancer Agents

(2015) Mariano Stornaiuolo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bax Regulates Neuronal Ca2+ Homeostasis

(2015) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

(2015) Lauren A. Barclay et al.   MOLECULAR CELL

Redefining the BH3 Death Domain as a ‘Short Linear Motif’

(2015) Abdel Aouacheria et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax and show no preference for Bak versus Bax

(2015) C Hockings et al.   Cell Death & Disease

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

Regulating cell death at, on, and in membranes

(2014) Xiaoke Chi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Temporal mismatch between pain behaviour, skin Nerve Growth Factor and intra-epidermal nerve fibre density in trigeminal neuropathic pain

(2014) Laura J Evans et al.   BMC NEUROSCIENCE

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

(2014) Jingzhen Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis

(2014) G. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

(2014) A Shamas-Din et al.   Cell Death & Disease

Small-molecule Bax agonists for cancer therapy

(2014) Meiguo Xin et al.   Nature Communications

Rho-kinase: regulation, (dys)function, and inhibition

(2013) Ehsan Amin et al.   BIOLOGICAL CHEMISTRY

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation

(2013) R Peng et al.   CELL DEATH AND DIFFERENTIATION

Intracellular localization of the BCL-2 family member BOK and functional implications

(2013) N Echeverry et al.   CELL DEATH AND DIFFERENTIATION

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Direct BAKtivation

(2013) Loren D. Walensky   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BID-induced structural changes in BAK promote apoptosis

(2013) Tudor Moldoveanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

(2012) Toru Okamoto et al.   ACS Chemical Biology

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Direct and selective small-molecule activation of proapoptotic BAX

(2012) Evripidis Gavathiotis et al.   Nature Chemical Biology

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA

(2012) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

(2010) Bonsu Ku et al.   CELL RESEARCH

Apoptotic Regulation by MCL-1 through Heterodimerization

(2010) Qian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Apaf-1-caspase-9 apoptosome

(2010) S. B. Bratton et al.   JOURNAL OF CELL SCIENCE

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

(2010) F. Leveille et al.   JOURNAL OF NEUROSCIENCE

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MAC inhibitors suppress mitochondrial apoptosis

(2009) Pablo M. Peixoto et al.   BIOCHEMICAL JOURNAL

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells

(2009) David A. Claassen et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Type I and Type II Pathways of Fas-mediated Apoptosis Are Differentially Controlled by XIAP

(2009) Z. Hao et al.   Journal of Molecular Cell Biology

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY