Revisiting Pyrazolo[3,4-d]pyrimidine Nucleosides as Anti-Trypanosoma cruzi and Antileishmanial Agents

Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents

(2021) Jakob Bouton et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents

(2020) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

(2020) Advait Nagle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationship Exploration of 3′-Deoxy-7-deazapurine Nucleoside Analogues as Anti-Trypanosoma brucei Agents

(2020) Fabian Hulpia et al.   ACS Infectious Diseases

Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

(2020) Peter C Dumoulin et al.   eLife

Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents

(2020) Jakob Bouton et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current and emerging medications for the treatment of leishmaniasis

(2019) Jaya Chakravarty et al.   EXPERT OPINION ON PHARMACOTHERAPY

Chagas Disease: From Discovery to a Worldwide Health Problem

(2019) Kárita Cláudia Freitas Lidani et al.   Frontiers in Public Health

Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

(2019) Cai Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

(2019) Fabian Hulpia et al.   Nature Communications

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

Canine visceral leishmaniasis: Diagnosis and management of the reservoir living among us

(2018) Bruno L. Travi et al.   PLoS Neglected Tropical Diseases

In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series

(2018) M. Van den Kerkhof et al.   International Journal for Parasitology-Drugs and Drug Resistance

Discovery of novel 7-aryl 7-deazapurine 3’-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

(2018) Fabian Hulpia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leishmaniasis

(2018) Sakib Burza et al.   LANCET

Challenges and recent progress in drug discovery for tropical diseases

(2018) Manu De Rycker et al.   NATURE

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

(2018) Susan Wyllie et al.   NATURE

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

(2018) Michael G. Thomas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Experimental combination therapy using low doses of benznidazole and allopurinol in mouse models of Trypanosoma cruzi chronic infection

(2018) Marcela Silvina Rial et al.   PARASITOLOGY

Drug Discovery for Kinetoplastid Diseases: Future Directions

(2018) Srinivasa P. S. Rao et al.   ACS Infectious Diseases

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phenotypic screening approaches for Chagas disease drug discovery

(2017) Eric Chatelain et al.   Expert Opinion on Drug Discovery

Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii

(2017) Florentine U. Rutaganira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palladium-Catalyzed Carbonylative Transformation of Organic Halides with Formic Acid as the Coupling Partner and CO Source: Synthesis of Carboxylic Acids

(2017) Fu-Peng Wu et al.   JOURNAL OF ORGANIC CHEMISTRY

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Chemotherapeutics of visceral leishmaniasis: present and future developments

(2017) SHYAM SUNDAR et al.   PARASITOLOGY

Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole

(2017) Soumaya Yaich et al.   ANNALS OF SAUDI MEDICINE

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

(2016) Shilpi Khare et al.   NATURE

Socioeconomic Inequalities in Neglected Tropical Diseases: A Systematic Review

(2016) Tanja A. J. Houweling et al.   PLoS Neglected Tropical Diseases

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly SensitiveIn VivoImaging

(2015) Amanda Fortes Francisco et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Translational challenges of animal models in Chagas disease drug development: a review

(2015) Eric Chatelain et al.   Drug Design Development and Therapy

In VitroandIn VivoBiological Effects of Novel Arylimidamide Derivatives against Trypanosoma cruzi

(2014) Bruno Lisboa Timm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

1,3-Disubstituted-4-Aminopyrazolo [3, 4-d] Pyrimidines, a New Class of Potent Inhibitors for Phospholipase D

(2014) Aditya Kulkarni et al.   Chemical Biology & Drug Design

In VitroandIn VivoStudies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

(2013) Maria de Nazaré Correia Soeiro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global economic burden of Chagas disease: a computational simulation model

(2013) Bruce Y Lee et al.   LANCET INFECTIOUS DISEASES

Palladium-Catalyzed Fluorocarbonylation Using N-Formylsaccharin as CO Source: General Access to Carboxylic Acid Derivatives

(2013) Tsuyoshi Ueda et al.   ORGANIC LETTERS

Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua

(2013) NOELIA L. GROSSO et al.   PARASITOLOGY

Mechanisms of Trypanosoma cruzi persistence in Chagas disease

(2012) Fnu Nagajyothi et al.   CELLULAR MICROBIOLOGY

Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding chlorides

(2012) Xiujuan Feng et al.   CHEMICAL COMMUNICATIONS

Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study

(2012) D. E. Perez-Mazliah et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Trichlorophenyl Formate: Highly Reactive and Easily Accessible Crystalline CO Surrogate for Palladium-Catalyzed Carbonylation of Aryl/Alkenyl Halides and Triflates

(2012) Tsuyoshi Ueda et al.   ORGANIC LETTERS

Purine salvage in Leishmania: complex or simple by design?

(2012) Jan M. Boitz et al.   TRENDS IN PARASITOLOGY

Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease

(2011) Adaliene Versiani Matos Ferreira et al.   MICROBES AND INFECTION

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY

Sodium Bromodifluoroacetate: A Difluorocarbene Source for the Synthesis of gem-Difluorocyclopropanes

(2010) Hideki Amii et al.   SYNTHESIS-STUTTGART

Synthesis of Pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones

(2009) Yaojun Gao et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi

(2009) D. G. J. BATISTA et al.   PARASITOLOGY

A Systematic Review of Studies on Heart Transplantation for Patients With End-Stage Chagas’ Heart Disease

(2008) Reinaldo B. Bestetti et al.   JOURNAL OF CARDIAC FAILURE