Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents

Structure–Activity Relationship Exploration of 3′-Deoxy-7-deazapurine Nucleoside Analogues as Anti-Trypanosoma brucei Agents

(2020) Fabian Hulpia et al.   ACS Infectious Diseases

Fexinidazole: First Global Approval

(2019) Emma D. Deeks   DRUGS

Walking a tightrope: drug discovery in visceral leishmaniasis

(2019) Rafael Balaña-Fouce et al.   DRUG DISCOVERY TODAY

Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents

(2019) Cai Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

(2019) Fabian Hulpia et al.   Nature Communications

Chagas disease

(2018) José A Pérez-Molina et al.   LANCET

Synthesis of a 3′- C -ethynyl-β- d -ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel 7-aryl 7-deazapurine 3’-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

(2018) Fabian Hulpia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leishmaniasis

(2018) Sakib Burza et al.   LANCET

The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis

(2018) Michael P. Barrett   PLoS Neglected Tropical Diseases

Drug Discovery for Kinetoplastid Diseases: Future Directions

(2018) Srinivasa P. S. Rao et al.   ACS Infectious Diseases

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated nucleosides as an important class of anticancer and antiviral agents

(2017) Alessandra Cavaliere et al.   Future Medicinal Chemistry

Human African trypanosomiasis

(2017) Philippe Büscher et al.   LANCET

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Chagas disease research and development: Is there light at the end of the tunnel?

(2017) Eric Chatelain   Computational and Structural Biotechnology Journal

Additions of Thiols to 7-Vinyl-7-deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2′-Deoxyadenosine, dATP and DNA

(2016) Michaela Slavíčková et al.   JOURNAL OF ORGANIC CHEMISTRY

Prospects for vaccination against pathogenic African trypanosomes

(2016) S. J. Black et al.   PARASITE IMMUNOLOGY

Status of vaccine research and development of vaccines for Chagas disease

(2016) Coreen M. Beaumier et al.   VACCINE

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

(2015) Hang Ren et al.   Beilstein Journal of Organic Chemistry

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis

(2015) Surendra Dawadi et al.   JOURNAL OF ORGANIC CHEMISTRY

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and applications of fluorinated nucleoside analogues

(2012) Hanna Wójtowicz-Rajchel   JOURNAL OF FLUORINE CHEMISTRY

Purine salvage in Leishmania: complex or simple by design?

(2012) Jan M. Boitz et al.   TRENDS IN PARASITOLOGY

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

(2012) Wenyu Yu et al.   Nature Communications

Inhibition of Nonmammalian Glycosidases by Azetidine Iminosugars Derived from Stable 3,5-Di-O-triflates of Pentoses

(2011) Gabriel M. J. Lenagh-Snow et al.   ORGANIC LETTERS

Efficient and Practical Synthesis of 5′-Deoxytubercidin and Its Analogues via Vorbrüggen Glycosylation

(2011) Qiang Xiao et al.   SYNTHESIS-STUTTGART

Evaluation of Nucleoside Hydrolase Inhibitors for Treatment of African Trypanosomiasis

(2010) M. Berg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY

Efficient Synthesis of Deazaguanosine-Derived tRNA Nucleosides PreQ0, PreQ1, and Archaeosine Using the Turbo-Grignard Method

(2010) Tobias Brückl et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chemoselective Staudinger Strategy in the Practical, Fit for Purpose, Gram-Scale Synthesis of an HCV RNA Polymerase Inhibitor

(2010) Louis-Charles Campeau et al.   SYNLETT

Fluorinated nucleosides: Synthesis and biological implication

(2008) Peng Liu et al.   JOURNAL OF FLUORINE CHEMISTRY