Toward the identification of ZDHHC enzymes required for palmitoylation of viral protein as potential drug targets

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

(2019) Shuofeng Yuan et al.   Nature Communications

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

(2019) Shuyang Chen et al.   Nature Communications

STING palmitoylation as a therapeutic target

(2019) Anne Louise Hansen et al.   Cellular & Molecular Immunology

Cholesterol binding to the transmembrane region of a group 2 HA of Influenza virus is essential for virus replication affecting both virus assembly and HA's fusion activity

(2019) Bodan Hu et al.   JOURNAL OF VIROLOGY

Domains of the TF protein important in regulating its own palmitoylation

(2019) Jolene Ramsey et al.   VIROLOGY

Palmitoylation in apicomplexan parasites: from established regulatory roles to putative new functions

(2019) Maria M. Corvi et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Acylation – A New Means to Control Traffic Through the Golgi

(2019) Andreas M. Ernst et al.   Frontiers in Cell and Developmental Biology

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Structure-based design of targeted covalent inhibitors

(2018) Richard Lonsdale et al.   CHEMICAL SOCIETY REVIEWS

The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics

(2018) María-Eugenia Zaballa et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Emerging Roles of DHHC-mediated Protein S -palmitoylation in Physiological and Pathophysiological Context

(2018) Indranil De et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Fatty acyl recognition and transfer by an integral membraneS-acyltransferase

(2018) Mitra S. Rana et al.   SCIENCE

Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

(2018) Christophe Chopard et al.   Nature Communications

Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes

(2018) Rahul S. Kathayat et al.   Nature Communications

Protein Palmitoylation and Its Role in Bacterial and Viral Infections

(2018) Justyna Sobocińska et al.   Frontiers in Immunology

Protein palmitoylation and cancer

(2018) Pin‐Joe Ko et al.   EMBO REPORTS

Influenza hemagglutinin membrane anchor

(2018) Donald J. Benton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular mechanism of DHHC protein acyltransferases

(2018) Mitra S. Rana et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi

(2018) Andreas M. Ernst et al.   DEVELOPMENTAL CELL

Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1

(2018) Na Zhang et al.   JOURNAL OF VIROLOGY

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

(2018) Jérôme Gouttenoire et al.   PLoS Pathogens

An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger

(2017) Fiona Plain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity

(2017) Temet M. McMichael et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An outlook on protein S-acylation in plants: what are the next steps?

(2017) Piers A Hemsley   JOURNAL OF EXPERIMENTAL BOTANY

The absence of DHHC3 affects primary and latent HSV-1 infection

(2017) Shaohui Wang et al.   JOURNAL OF VIROLOGY

Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K

(2017) Shaohui Wang et al.   JOURNAL OF VIROLOGY

The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells

(2017) Christine Salaun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry

(2017) Jennifer Greaves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular fatty acid synthase is required for late stages of HIV-1 replication

(2017) Manjusha M. Kulkarni et al.   Retrovirology

Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase

(2017) Raffaello Verardi et al.   STRUCTURE

The role of S-acylation in protein trafficking

(2017) Jose L. Daniotti et al.   TRAFFIC

Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets

(2017) Thomas Lanyon-Hogg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

(2017) Remco N. P. Rodenburg et al.   Nature Communications

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

(2017) Laurence Abrami et al.   eLife

Global, site-specific analysis of neuronal protein S-acylation

(2017) Mark O. Collins et al.   Scientific Reports

Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)

(2016) Sang Joon Won et al.   ACS Chemical Biology

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library

(2016) Laura D. Hamel et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Proteomic analysis of fatty-acylated proteins

(2016) Tao Peng et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Palmitoylation of Sindbis Virus TF Protein Regulates Its Plasma Membrane Localization and Subsequent Incorporation into Virions

(2016) Jolene Ramsey et al.   JOURNAL OF VIROLOGY

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

(2016) PuiYee Chan et al.   Nature Chemical Biology

Palmitoylation in Alzheimer⿿s disease and other neurodegenerative diseases

(2016) Eunsil Cho et al.   PHARMACOLOGICAL RESEARCH

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

(2016) Tiziano Dallavilla et al.   PLoS Computational Biology

A cholesterol consensus motif is required for efficient intracellular transport and raft association of a group 2 HA from influenza virus

(2015) Maren de Vries et al.   BIOCHEMICAL JOURNAL

The zDHHC family of S-acyltransferases

(2015) Kimon Lemonidis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aberrant palmitoylation in Huntington disease

(2015) Shaun S. Sanders et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Single-Particle Cryo-EM at Crystallographic Resolution

(2015) Yifan Cheng   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

The role of stearate attachment to the hemagglutinin-esterase-fusion glycoprotein HEF of influenza C virus

(2015) Mingyang Wang et al.   CELLULAR MICROBIOLOGY

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics

(2015) Remigiusz A. Serwa et al.   CHEMISTRY & BIOLOGY

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

(2015) A. D. Cox et al.   CLINICAL CANCER RESEARCH

The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc

(2015) Colin D. Gottlieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation Strengthens Cholesterol-dependent Multimerization and Fusion Activity of Human Cytomegalovirus Glycoprotein B (gB)

(2015) Marco Patrone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host Cell-catalyzedS-Palmitoylation Mediates Golgi Targeting of theLegionellaUbiquitin Ligase GobX

(2015) Yi-Han Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13S-Acyltransferases

(2015) Kimon Lemonidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated

(2015) David Paul et al.   JOURNAL OF GENERAL VIROLOGY

The Physiology of Protein S-acylation

(2015) Luke H. Chamberlain et al.   PHYSIOLOGICAL REVIEWS

Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses

(2015) Yamini M. Ohol et al.   PLoS One

Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins

(2015) Ditte Neess et al.   PROGRESS IN LIPID RESEARCH

S-acylation of influenza virus proteins: Are enzymes for fatty acid attachment promising drug targets?

(2015) Michael Veit et al.   VACCINE

Two Cytoplasmic Acylation Sites and an Adjacent Hydrophobic Residue, but No Other Conserved Amino Acids in the Cytoplasmic Tail of HA from Influenza A Virus Are Crucial for Virus Replication

(2015) Stefanie Siche et al.   Viruses-Basel

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

(2015) David Tse Shen Lin et al.   eLife

A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening

(2014) Laura D. Hamel et al.   ANALYTICAL BIOCHEMISTRY

The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling

(2014) Qian Zhou et al.   Cell Host & Microbe

Targeting protein palmitoylation: selective inhibitors and implications in disease

(2014) Burzin Chavda et al.   Expert Opinion on Drug Discovery

Site-specificS-Acylation of Influenza Virus Hemagglutinin

(2014) Katharina Brett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation is required for intracellular trafficking of influenza B virus NB protein and efficient influenza B virus growth in vitro

(2014) A. Demers et al.   JOURNAL OF GENERAL VIROLOGY

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity

(2014) Kimon Lemonidis et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of SH3 Domain Proteins Interacting with the Cytoplasmic Tail of the A Disintegrin and Metalloprotease 10 (ADAM10)

(2014) Henriette Ebsen et al.   PLoS One

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

(2014) Gregory J. Fredericks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate recognition by the cell surface palmitoyl transferase DHHC5

(2014) Jacqueline Howie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved and host-specific features of influenza virion architecture

(2014) Edward C. Hutchinson et al.   Nature Communications

Zinc co-ordination by the DHHC cysteine-rich domain of the palmitoyltransferase Swf1

(2013) Ayelén González Montoro et al.   BIOCHEMICAL JOURNAL

Palmitoylation of influenza virus proteins

(2013) Michael Veit et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Palmitoylation, pathogens and their host: Table 1

(2013) Mathieu Blanc et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

(2013) Eryan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of DHHC ProteinS-Acyltransferases

(2013) Jianbin Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression

(2013) G. M. Thomas et al.   JOURNAL OF NEUROSCIENCE

Structural investigation of influenza virus hemagglutinin membrane-anchoring peptide

(2013) K. S. Mineev et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Palmitoylation of virus proteins

(2012) Michael Veit   BIOLOGY OF THE CELL

Palmitoylated calnexin is a key component of the ribosome-translocon complex

(2012) Asvin KK Lakkaraju et al.   EMBO JOURNAL

Mutation of a raft-targeting signal in the transmembrane region retards transport of influenza virus hemagglutinin through the Golgi

(2012) Stephanie Engel et al.   FEBS LETTERS

DHHC ProteinS-Acyltransferases Use Similar Ping-Pong Kinetic Mechanisms but Display Different Acyl-CoA Specificities

(2012) Benjamin C. Jennings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Palmitoylation and Ubiquitination Differentially Regulate Interferon-induced Transmembrane Protein 3 (IFITM3)-mediated Resistance to Influenza Virus

(2012) Jacob S. Yount et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels

(2012) Lijun Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane

(2012) Mathias J. Gerl et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation by DHHC5/8 Targets GRIP1 to Dendritic Endosomes to Regulate AMPA-R Trafficking

(2012) Gareth M. Thomas et al.   NEURON

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intrinsic membrane association of the cytoplasmic tail of influenza virus M2 protein and lateral membrane sorting regulated by cholesterol binding and palmitoylation

(2011) Bastian Thaa et al.   BIOCHEMICAL JOURNAL

Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers

(2011) Larisa V. Kordyukova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Endoplasmic Reticulum Localization of DHHC Palmitoyltransferases Mediated by Lysine-based Sorting Signals

(2011) Oforiwa A. Gorleku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth of influenza A virus is not impeded by simultaneous removal of the cholesterol-binding and acylation sites in the M2 protein

(2011) B. Thaa et al.   JOURNAL OF GENERAL VIROLOGY

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

Palmitoylation of CM2 is dispensable to influenza C virus replication

(2011) Yasushi Muraki et al.   VIRUS RESEARCH

Multiple Palmitoyltransferases Are Required for Palmitoylation-dependent Regulation of Large Conductance Calcium- and Voltage-activated Potassium Channels

(2010) Lijun Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DHHC5 Interacts with PDZ Domain 3 of Post-synaptic Density-95 (PSD-95) Protein and Plays a Role in Learning and Memory

(2010) Yi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of the SNAP25 Protein Family

(2010) Jennifer Greaves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Palmitoylome profiling reveals S-palmitoylation–dependent antiviral activity of IFITM3

(2010) Jacob S Yount et al.   Nature Chemical Biology

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43

(2010) Vanesa M. Tomatis et al.   PLoS One

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell–cell fusion but not interaction with M protein

(2010) Corrin E. McBride et al.   VIROLOGY

FLIM-FRET and FRAP reveal association of influenza virus haemagglutinin with membrane rafts

(2009) Stephanie Engel et al.   BIOCHEMICAL JOURNAL

Molecular Recognition of the Palmitoylation Substrate Vac8 by Its Palmitoyltransferase Pfa3

(2009) Marissa J. Nadolski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Spike Protein Endodomains in Regulating Coronavirus Entry

(2009) Ana Shulla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of Hepatitis C Virus Core Protein Is Important for Virion Production

(2009) Nathalie Majeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of the Influenza A Virus M2 Protein Is Not Required for Virus Replication In Vitro but Contributes to Virus Virulence

(2009) M. L. Grantham et al.   JOURNAL OF VIROLOGY

Proteome Scale Characterization of HumanS-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes

(2009) Wei Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases

(2009) Jennifer Greaves et al.   MOLECULAR BIOLOGY OF THE CELL

Site-specific attachment of palmitate or stearate to cytoplasmic versus transmembrane cysteines is a common feature of viral spike proteins

(2009) Larisa V. Kordyukova et al.   VIROLOGY

Myristylation and palmitylation of HSV-1 UL11 are not essential for its function

(2009) Nicholas L. Baird et al.   VIROLOGY

Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production

(2008) Wei Yang et al.   HEPATOLOGY

Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replication

(2008) K. Kiiver et al.   JOURNAL OF GENERAL VIROLOGY

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

(2008) Benjamin C. Jennings et al.   JOURNAL OF LIPID RESEARCH

Importance of Conserved Cysteine Residues in the Coronavirus Envelope Protein

(2008) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Envelope Protein Palmitoylations Are Crucial for Murine Coronavirus Assembly

(2008) J. A. Boscarino et al.   JOURNAL OF VIROLOGY

S Acylation of the Hemagglutinin of Influenza Viruses: Mass Spectrometry Reveals Site-Specific Attachment of Stearic Acid to a Transmembrane Cysteine

(2008) L. V. Kordyukova et al.   JOURNAL OF VIROLOGY

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue

(2007) Morris A. Kostiuk et al.   FASEB JOURNAL