OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

(2019) Rebecca A. Drummond et al.   NATURE IMMUNOLOGY

Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity

(2019) Jia Tong Loh et al.   JOURNAL OF CLINICAL INVESTIGATION

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

(2019) Michael J. Holliday et al.   Nature Communications

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

(2018) Fan Yao et al.   Nature Communications

Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome

(2018) Liting Zhang et al.   PLoS Pathogens

Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders

(2018) Dan Lu et al.   JOURNAL OF AUTOIMMUNITY

Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB

(2017) Yun-Yun Guo et al.   JOURNAL OF NEUROSCIENCE

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression

(2017) Xueqiang Zhao et al.   NATURE MEDICINE

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

(2017) Zhengkui Zhang et al.   Nature Communications

Inhibition of CBLB protects from lethal Candida albicans sepsis

(2016) Gerald Wirnsberger et al.   NATURE MEDICINE

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity

(2016) Susanne Roth et al.   Cell Reports

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street

(2015) David M. Underhill et al.   IMMUNITY

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

Genetic errors of the human caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity

(2015) Rebeca Pérez de Diego et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

(2015) Zihou Deng et al.   NATURE IMMUNOLOGY

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System

(2015) Rebecca A. Drummond et al.   PLoS Pathogens

Defect of CARD9 Leads to Impaired Accumulation of Gamma Interferon-Producing Memory Phenotype T Cells in Lungs and Increased Susceptibility to Pulmonary Infection with Cryptococcus neoformans

(2014) Hideki Yamamoto et al.   INFECTION AND IMMUNITY

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

(2014) Xin-Ming Jia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Antifungal innate immunity: recognition and inflammatory networks

(2014) Katharina L. Becker et al.   Seminars in Immunopathology

Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency

(2013) A. Drewniak et al.   BLOOD

Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities

(2013) Hilmar Wisplinghoff et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

(2013) Susanne Roth et al.   TRENDS IN IMMUNOLOGY

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

(2012) Lara M Kingeter et al.   Cellular & Molecular Immunology

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

C-type lectin receptors orchestrate antifungal immunity

(2012) Sarah E Hardison et al.   NATURE IMMUNOLOGY

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung

(2012) Anupam Jhingran et al.   Cell Reports

Phospholipase Cγ2 (PLCγ2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune Responses

(2011) Sara Gorjestani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca2+Flux and Cytokine Production in Dendritic Cells

(2009) Shengli Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE