Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer

Fibrosis and cancer: A strained relationship

(2020) Bram Piersma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

(2020) Ori Maller et al.   NATURE MATERIALS

YAP-independent mechanotransduction drives breast cancer progression

(2019) Joanna Y. Lee et al.   Nature Communications

Coherency image analysis to quantify collagen architecture: implications in scar assessment

(2018) T. D. Clemons et al.   RSC Advances

Paclitaxel With Inhibitor of Apoptosis Antagonist, LCL161, for Localized Triple-Negative Breast Cancer, Prospectively Stratified by Gene Signature in a Biomarker-Driven Neoadjuvant Trial

(2018) Aditya Bardia et al.   JOURNAL OF CLINICAL ONCOLOGY

Long-Term Prognostic Risk After Neoadjuvant Chemotherapy Associated With Residual Cancer Burden and Breast Cancer Subtype

(2017) W. Fraser Symmans et al.   JOURNAL OF CLINICAL ONCOLOGY

An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer

(2017) Matthew Ashenden et al.   MOLECULAR CANCER THERAPEUTICS

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells

(2017) Joshua D. Stender et al.   MOLECULAR CELL

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Molecular Pathways: The Balance between Cancer and the Immune System Challenges the Therapeutic Specificity of Targeting Nuclear Factor- B Signaling for Cancer Treatment

(2016) K. P. Zeligs et al.   CLINICAL CANCER RESEARCH

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells

(2016) Tze-Sian Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monitoring developmental force distributions in reconstituted embryonic epithelia

(2016) L. Przybyla et al.   METHODS

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

(2014) Thuy V. Nguyen et al.   BIOMATERIALS

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

(2014) Laura Tornatore et al.   CANCER CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis

(2014) Patricia Cortazar et al.   LANCET

Neoadjuvant Chemotherapy and Short-term Morbidity in Patients Undergoing Mastectomy With and Without Breast Reconstruction

(2014) Nicholas B. Abt et al.   JAMA Surgery

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

(2013) X. Zhang et al.   CANCER RESEARCH

NF- B Regulates Radioresistance Mediated By  1-Integrin in Three-Dimensional Culture of Breast Cancer Cells

(2013) K. M. Ahmed et al.   CANCER RESEARCH

Taxane resistance in breast cancer: Mechanisms, predictive biomarkers and circumvention strategies

(2012) S. Murray et al.   CANCER TREATMENT REVIEWS

Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes

(2012) Gunter von Minckwitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Effect of Aging on Elastin Functionality in Human Cerebral Arteries

(2009) Edouard Fonck et al.   STROKE

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion

(2008) A. K. Fournier et al.   JOURNAL OF CELL SCIENCE

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE