17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin

Transcriptional and Cellular Diversity of the Human Heart

(2020) Nathan R. Tucker et al.   CIRCULATION

Sex Differences in Right Ventricular-pulmonary Arterial Coupling in Pulmonary Arterial Hypertension

(2020) Khodr Tello et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of The Long Non-Coding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension

(2020) Junichi Omura et al.   CIRCULATION

Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension

(2019) Aurélie Hautefort et al.   CIRCULATION

Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research

(2018) Steeve Provencher et al.   CIRCULATION RESEARCH

Beyond oestrogens: towards a broader evaluation of the hormone profile in pulmonary arterial hypertension

(2018) Jessica B. Badlam et al.   EUROPEAN RESPIRATORY JOURNAL

PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

(2018) Ekaterina Legchenko et al.   Science Translational Medicine

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement

(2018) Tim Lahm et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts

(2018) Peng Hu et al.   GENES & DEVELOPMENT

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

(2018) Anton Vonk Noordegraaf et al.   EUROPEAN RESPIRATORY JOURNAL

17β-Estradiol Mediates Superior Adaptation Of Right Ventricular Function To Acute Strenuous Exercise In Female Rats With Severe Pulmonary Hypertension

(2016) Tim Lahm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle

(2016) Megha H. Talati et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2016) Cathelijne E. van der Bruggen et al.   CIRCULATION

Combination therapy versus monotherapy for pulmonary arterial hypertension: a meta-analysis

(2016) Annie Christine Lajoie et al.   Lancet Respiratory Medicine

Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones

(2015) Andrea L. Frump et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sex Affects Bone Morphogenetic Protein Type II Receptor Signaling in Pulmonary Artery Smooth Muscle Cells

(2015) Kirsty M. Mair et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oestrogen receptor alpha in pulmonary hypertension

(2015) Audrey F. Wright et al.   CARDIOVASCULAR RESEARCH

Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2015) François Potus et al.   CIRCULATION

The Emerging Potential of the Apelin-APJ System in Heart Failure

(2015) Jonathan R. Dalzell et al.   JOURNAL OF CARDIAC FAILURE

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension

(2015) Lu Long et al.   NATURE MEDICINE

Right Ventricular Sex Differences in Patients with Idiopathic Pulmonary Arterial Hypertension Characterised by Magnetic Resonance Imaging: Pair-Matched Case Controlled Study

(2015) Andrew J. Swift et al.   PLoS One

Progress in solving the sex hormone paradox in pulmonary hypertension

(2014) Tim Lahm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sex-Dependent Influence of Endogenous Estrogen in Pulmonary Hypertension

(2014) Kirsty M. Mair et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Apelin Increases Cardiac Contractility via Protein Kinase Cε- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

(2014) Ábel Perjés et al.   PLoS One

The Right Ventricle Explains Sex Differences in Survival in Idiopathic Pulmonary Arterial Hypertension

(2013) Wouter Jacobs et al.   CHEST

Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development

(2013) Yujung Kang et al.   CIRCULATION RESEARCH

Sex and haemodynamics in pulmonary arterial hypertension

(2013) C. E. Ventetuolo et al.   EUROPEAN RESPIRATORY JOURNAL

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gender, Sex Hormones and Pulmonary Hypertension

(2013) Eric D. Austin et al.   Pulmonary Circulation

17β-Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor–mediated Effects

(2012) Tim Lahm et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biology of the apelin-APJ axis in vascular formation

(2012) H. Kidoya et al.   JOURNAL OF BIOCHEMISTRY

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Hydrophobic Interactions Improve Selectivity to ERα for Benzothiophene SERMs

(2012) Michael J. Chalmers et al.   ACS Medicinal Chemistry Letters

BMPR2 expression is suppressed by signaling through the estrogen receptor

(2012) Eric D Austin et al.   Biology of Sex Differences

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary Hypertension

(2011) Jennifer I. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

(2011) Suparna M. Chandra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Estrogen Signaling and Cardiovascular Disease

(2011) Elizabeth Murphy   CIRCULATION RESEARCH

Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

(2011) Tero-Pekka Alastalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension

(2010) Revathi Rajkumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sex Hormones Are Associated with Right Ventricular Structure and Function

(2010) Corey E. Ventetuolo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Predicting Survival in Pulmonary Arterial Hypertension

(2010) Raymond L. Benza et al.   CIRCULATION

Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

(2010) M. Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Selective estrogen receptor-α agonist provides widespread heart and vascular protection with enhanced endothelial progenitor cell mobilization in the absence of uterotrophic action

(2010) Chiara Bolego et al.   FASEB JOURNAL

Genetic Risk Factors for Portopulmonary Hypertension in Patients with Advanced Liver Disease

(2009) Kari E. Roberts et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Right Ventricle Under Pressure

(2009) Harm J. Bogaard et al.   CHEST

Myocyte Enhancer Factor 2 and Class II Histone Deacetylases Control a Gender-Specific Pathway of Cardioprotection Mediated by the Estrogen Receptor

(2009) Eva van Rooij et al.   CIRCULATION RESEARCH

BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis

(2009) Hideyuki Beppu et al.   DEVELOPMENTAL BIOLOGY

Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2pathway

(2008) Bo Bai et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Right Ventricular Function in Cardiovascular Disease, Part I

(2008) François Haddad et al.   CIRCULATION

In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure

(2007) Ahmad Y. Sheikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY