Progress in solving the sex hormone paradox in pulmonary hypertension

Interaction between Bone Morphogenetic Protein Receptor Type 2 and Estrogenic Compounds in Pulmonary Arterial Hypertension

(2014) Joshua P. Fessel et al.   Pulmonary Circulation

Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation

(2013) Sarah H. Lindsey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dehydroepiandrosterone restores right ventricular structure and function in rats with severe pulmonary arterial hypertension

(2013) Abdallah Alzoubi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor

(2013) Megan M. Greenlee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension

(2013) John J. Ryan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Abnormal Liver Uptake of99mTc-Macroaggregated Albumin in a Patient with Superior Vena Cava Syndrome

(2013) Mohammad Al-Makhzomi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Causes and Circumstances of Death in Pulmonary Arterial Hypertension

(2013) Adriano R. Tonelli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

(2013) Yvonne Dempsie et al.   CARDIOVASCULAR RESEARCH

The Right Ventricle Explains Sex Differences in Survival in Idiopathic Pulmonary Arterial Hypertension

(2013) Wouter Jacobs et al.   CHEST

Anticoagulation and Survival in Pulmonary Arterial Hypertension

(2013) Karen M. Olsson et al.   CIRCULATION

Drastic Shift From Positive to Negative Estrogen Effect on Bone Morphogenetic Protein Signaling in Pulmonary Arterial Endothelial Cells Under Hypoxia

(2013) Hiroaki Ichimori et al.   CIRCULATION JOURNAL

Pathology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   CLINICS IN CHEST MEDICINE

Sex and haemodynamics in pulmonary arterial hypertension

(2013) C. E. Ventetuolo et al.   EUROPEAN RESPIRATORY JOURNAL

The influence of gender on the development of pulmonary arterial hypertension

(2013) Yvonne Dempsie et al.   EXPERIMENTAL PHYSIOLOGY

Endogenous Estrogen Attenuates Hypoxia-Induced Pulmonary Hypertension by Inhibiting Pulmonary Arterial Vasoconstriction and Pulmonary Arterial Smooth Muscle Cells Proliferation

(2013) Dunquan Xu et al.   International Journal of Medical Sciences

Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

(2013) Rubin M. Tuder et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants

(2013) Eric Dumas de la Roque et al.   PEDIATRIC RESEARCH

Gender, Sex Hormones and Pulmonary Hypertension

(2013) Eric D. Austin et al.   Pulmonary Circulation

In pursuit of scientific excellence: sex matters

(2012) Virginia M. Miller   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

(2012) Jose Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Estrogen effects on human airway smooth muscle involve cAMP and protein kinase A

(2012) Elizabeth A. Townsend et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

17β-Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor–mediated Effects

(2012) Tim Lahm et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Changing Demographics, Epidemiology, and Survival of Incident Pulmonary Arterial Hypertension

(2012) Yi Ling et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Estrogen Paradox in Pulmonary Hypertension

(2012) Soban Umar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats

(2012) Hao Wang et al.   CARDIOVASCULAR RESEARCH

Exercise Stress Echocardiography of the Pulmonary Circulation

(2012) Paola Argiento et al.   CHEST

Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension

(2012) Kevin White et al.   CIRCULATION

Oestradiol ameliorates monocrotaline pulmonary hypertensionviaNO, prostacyclin and endothelin-1 pathways

(2012) Ping Yuan et al.   EUROPEAN RESPIRATORY JOURNAL

Survival in pulmonary hypertension in Spain: insights from the Spanish registry

(2012) Pilar Escribano-Subias et al.   EUROPEAN RESPIRATORY JOURNAL

Dehydroepiandrosterone reverses chronic hypoxia/reoxygenation-induced right ventricular dysfunction in rats

(2012) Eric Dumas de La Roque et al.   EUROPEAN RESPIRATORY JOURNAL

Genistein, a Soy Phytoestrogen, Reverses Severe Pulmonary Hypertension and Prevents Right Heart Failure in Rats

(2012) Humann Matori et al.   HYPERTENSION

Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension

(2012) Rangarajan D. Nadadur et al.   JOURNAL OF APPLIED PHYSIOLOGY

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Chronic Activation of the G Protein-Coupled Receptor 30 with Agonist G-1 Attenuates Heart Failure

(2012) Shoulei Kang et al.   PLoS One

Pregnancy Is Associated with Decreased Cardiac Proteasome Activity and Oxidative Stress in Mice

(2012) Andrea Iorga et al.   PLoS One

BMPR2 expression is suppressed by signaling through the estrogen receptor

(2012) Eric D Austin et al.   Biology of Sex Differences

Testosterone negatively regulates right ventricular load stress responses in mice

(2012) Anna R. Hemnes et al.   Pulmonary Circulation

Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension

(2011) Roxane Paulin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphatidylinositol 4,5-bisphosphate stimulates alveolar epithelial fluid clearance in male and female adult rats

(2011) Edgar E. Kooijman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genetically manipulated mouse models of lung disease: potential and pitfalls

(2011) Rebecca M. Baron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Estrogen Rescues Preexisting Severe Pulmonary Hypertension in Rats

(2011) Soban Umar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Making Sense of the Estrogen Paradox in Pulmonary Arterial Hypertension

(2011) Vinicio A. de Jesus Perez   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expression and Function of a Novel Variant of Estrogen Receptor–α36 in Murine Airways

(2011) Shuping Jia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sex Differences in the Diagnosis, Treatment, and Outcome of Patients With Pulmonary Arterial Hypertension Enrolled in the Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management

(2011) Shelley Shapiro et al.   CHEST

Race and Sex Differences in Response to Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension

(2011) Nicole B. Gabler et al.   CHEST

Sex and Race Differences in Right Ventricular Structure and Function

(2011) Steven M. Kawut et al.   CIRCULATION

Estrogen Signaling and Cardiovascular Disease

(2011) Elizabeth Murphy   CIRCULATION RESEARCH

17β-Estradiol Protects the Lung against Acute Injury: Possible Mediation by Vasoactive Intestinal Polypeptide

(2011) Sayyed A. Hamidi et al.   ENDOCRINOLOGY

Estrogen Receptor GPR30 Reduces Oxidative Stress and Proteinuria in the Salt-Sensitive Female mRen2.Lewis Rat

(2011) Sarah H. Lindsey et al.   HYPERTENSION

Non-nuclear Estrogen Receptor Signaling in the Endothelium

(2011) Qian Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vasodilation in Response to the GPR30 Agonist G-1 is Not Different From Estradiol in the mRen2.Lewis Female Rat

(2011) Sarah H Lindsey et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Progressive Right Ventricular Dysfunction in Patients With Pulmonary Arterial Hypertension Responding to Therapy

(2011) Mariëlle C. van de Veerdonk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH

(2011) Kevin White et al.   PHYSIOLOGICAL GENOMICS

Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension

(2010) Revathi Rajkumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rapid effects of estrogen on intracellular Ca2+ regulation in human airway smooth muscle

(2010) Elizabeth A. Townsend et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload

(2010) Daniela Fliegner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Plasma Levels of High-Density Lipoprotein Cholesterol and Outcomes in Pulmonary Arterial Hypertension

(2010) Gustavo A. Heresi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sex Hormones Are Associated with Right Ventricular Structure and Function

(2010) Corey E. Ventetuolo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The serotonin transporter, gender, and 17  oestradiol in the development of pulmonary arterial hypertension

(2010) K. White et al.   CARDIOVASCULAR RESEARCH

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Predicting Survival in Pulmonary Arterial Hypertension

(2010) Raymond L. Benza et al.   CIRCULATION

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension

(2010) M. Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Estrogens and Development of Pulmonary Hypertension: Interaction of Estradiol Metabolism and Pulmonary Vascular Disease

(2010) Stevan P Tofovic   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Synergistic Therapeutic Effects of 2-Methoxyestradiol With Either Sildenafil or Bosentan on Amelioration of Monocrotaline-induced Pulmonary Hypertension and Vascular Remodeling

(2010) Stevan P Tofovic et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

(2010) Ken L. Chambliss et al.   JOURNAL OF CLINICAL INVESTIGATION

Attenuation of Salt-Induced Cardiac Remodeling and Diastolic Dysfunction by the GPER Agonist G-1 in Female mRen2.Lewis Rats

(2010) Jewell A. Jessup et al.   PLoS One

2-Methoxyestradiol—Biology and mechanism of action

(2010) A.O. Mueck et al.   STEROIDS

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Estrogen receptor β mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia

(2009) Meijing Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Genetic Risk Factors for Portopulmonary Hypertension in Patients with Advanced Liver Disease

(2009) Kari E. Roberts et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of the Menstrual Cycle on Lung Function Variables in Women with Asthma

(2009) Samar Farha et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Estrogen Metabolism and Breast Cancer

(2009) Fritz F. Parl et al.   Annals of the New York Academy of Sciences

Estrogen Receptor α Expression in Both Endothelium and Hematopoietic Cells Is Required for the Accelerative Effect of Estradiol on Reendothelialization

(2009) Céline E. Toutain et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension

(2009) I. Morecroft et al.   CARDIOVASCULAR RESEARCH

The Right Ventricle Under Pressure

(2009) Harm J. Bogaard et al.   CHEST

Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   CHEST

Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure

(2009) Harm J. Bogaard et al.   CIRCULATION

Estrogen Receptor-β Activation Results in S-Nitrosylation of Proteins Involved in Cardioprotection

(2009) Jeffrey Lin et al.   CIRCULATION

Regulatory Role of G Protein–Coupled Estrogen Receptor for Vascular Function and Obesity

(2009) Elvira Haas et al.   CIRCULATION RESEARCH

The effects of estrogen on pulmonary artery vasoreactivity and hypoxic pulmonary vasoconstriction: Potential new clinical implications for an old hormone

(2009) Tim Lahm et al.   CRITICAL CARE MEDICINE

Chronic Treatment with the G Protein-Coupled Receptor 30 Agonist G-1 Decreases Blood Pressure in Ovariectomized mRen2.Lewis Rats

(2009) Sarah Hoffmann Lindsey et al.   ENDOCRINOLOGY

Estrogen Receptor-α as a Drug Target Candidate for Preventing Lung Inflammation

(2009) Elisabetta Vegeto et al.   ENDOCRINOLOGY

Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females

(2009) E. D. Austin et al.   EUROPEAN RESPIRATORY JOURNAL

2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats

(2009) Stevan P. Tofovic et al.   VASCULAR PHARMACOLOGY

Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone

(2008) Noriyuki Homma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Selective estrogen receptor-α and estrogen receptor-β agonists rapidly decrease pulmonary artery vasoconstriction by a nitric oxide-dependent mechanism

(2008) Tim Lahm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance

(2008) James West et al.   BMC Medical Genomics

Circulating 2-Hydroxy- and 16 -Hydroxy Estrone Levels and Risk of Breast Cancer among Postmenopausal Women

(2008) A. H. Eliassen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Determinants of Right Ventricular Ejection Fraction in Pulmonary Arterial Hypertension

(2008) Steven M. Kawut et al.   CHEST

Right Ventricular Function in Cardiovascular Disease, Part II

(2008) François Haddad et al.   CIRCULATION

Insulin resistance in pulmonary arterial hypertension

(2008) R. T. Zamanian et al.   EUROPEAN RESPIRATORY JOURNAL

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

(2008) Keizo Kanasaki et al.   NATURE

EXOGENOUS ESTROGEN RAPIDLY ATTENUATES PULMONARY ARTERY VASOREACTIVITY AND ACUTE HYPOXIC PULMONARY VASOCONSTRICTION

(2008) Tim Lahm et al.   SHOCK

2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling

(2008) Stevan P. Tofovic et al.   VASCULAR PHARMACOLOGY

Potential Mechanisms of Estrogen Quinone Carcinogenesis

(2007) Judy L. Bolton et al.   CHEMICAL RESEARCH IN TOXICOLOGY