β-adrenergic receptor signalling and its functional consequences in the diseased heart

Targets for therapy in sarcomeric cardiomyopathies

(2015) J. C. Tardiff et al.   CARDIOVASCULAR RESEARCH

Exercise and the Cardiovascular System

(2015) Carl J. Lavie et al.   CIRCULATION RESEARCH

Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart

(2014) Ø Ørstavik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes

(2014) Zeineb Haj Slimane et al.   CARDIOVASCULAR RESEARCH

Insulin Inhibits Cardiac Contractility by Inducing a Gi-Biased  2-Adrenergic Signaling in Hearts

(2014) Q. Fu et al.   DIABETES

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy

(2014)   EUROPEAN HEART JOURNAL

Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy

(2014) David Dweck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic signaling in heart failure: a balance of toxic and protective effects

(2014) Anthony J. Baker   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

β-Arrestin1–Biased β 1 -Adrenergic Receptor Signaling Regulates MicroRNA Processing

(2013) Il-man Kim et al.   CIRCULATION RESEARCH

Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes

(2013) Hind Mehel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2013 ACCF/AHA Guideline for the Management of Heart Failure

(2013) Clyde W. Yancy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist

(2013) Catherine E. Erickson et al.   PLoS One

Beta3-Adrenoreceptors in Cardiovasular Diseases: New Roles for an “Old” Receptor

(2013) Jean-Luc Balligand   Current Drug Delivery

Adrenergic receptors and metabolism: role in development of cardiovascular disease

(2013) Michele Ciccarelli et al.   Frontiers in Physiology

Adrenergic signaling and oxidative stress: a role for sirtuins?

(2013) Graziamaria Corbi et al.   Frontiers in Physiology

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy

(2013) Alessandro Cannavo et al.   Frontiers in Physiology

A-kinase anchoring proteins: Molecular regulators of the cardiac stress response

(2012) Dario Diviani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction

(2012) Nazha Hamdani et al.   CARDIOVASCULAR RESEARCH

AAV6. ARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

(2012) P. W. J. Raake et al.   EUROPEAN HEART JOURNAL

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC

(2012) et al.   EUROPEAN HEART JOURNAL

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

(2012) Tony Warne et al.   STRUCTURE

Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C

(2011) Gerrida M Uys et al.   BMC CELL BIOLOGY

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

(2011) Alessandra Stangherlin et al.   CIRCULATION RESEARCH

Compartmentalization of β-Adrenergic Signals in Cardiomyocytes

(2011) Yang K. Xiang   CIRCULATION RESEARCH

G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease

(2011) Stephen L. Belmonte et al.   CIRCULATION RESEARCH

Reorganized PKA-AKAP associations in the failing human heart

(2011) Thin-Thin Aye et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac myosin binding protein C phosphorylation in cardiac disease

(2011) Diederik W. D. Kuster et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Small Molecule Disruption of Gβγ Signaling Inhibits the Progression of Heart Failure

(2010) Liam M. Casey et al.   CIRCULATION RESEARCH

EFFECTS OF ACE INHIBITION AND BETA-BLOCKADE ON COLLAGEN REMODELLING IN THE HEART OF BIO 14.6 HAMSTERS

(2010) Abdul M. Mansoor et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cardiac Troponin T, a Sarcomeric AKAP, Tethers Protein Kinase A at the Myofilaments

(2010) C. Amelia Sumandea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selectively Engaging  -Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

(2010) J. D. Violin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

GRK mythology: G-protein receptor kinases in cardiovascular disease

(2009) Gerald W. Dorn   JOURNAL OF MOLECULAR MEDICINE-JMM

Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

(2009) C. W. Dessauer   MOLECULAR PHARMACOLOGY

Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance

(2009) Bing Luan et al.   NATURE

Metabolic remodelling of the failing heart: beneficial or detrimental?

(2008) M. van Bilsen et al.   CARDIOVASCULAR RESEARCH

Myocardial Adeno-Associated Virus Serotype 6–βARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure

(2008) Giuseppe Rengo et al.   CIRCULATION

Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

(2008) Giulietta Di Benedetto et al.   CIRCULATION RESEARCH

Disruption of Protein Kinase A Interaction with A-kinase-anchoring Proteins in the Heartin Vivo

(2008) Bradley K. McConnell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depressed Coronary Flow Reserve Is Associated With Decreased Myocardial Capillary Density in Patients With Heart Failure Due to Idiopathic Dilated Cardiomyopathy

(2008) Eleftheria P. Tsagalou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

β-adrenergic signaling in heart failure—adapt or die

(2008) Thomas Eschenhagen   NATURE MEDICINE

 -Blockers alprenolol and carvedilol stimulate  -arrestin-mediated EGFR transactivation

(2008) I.-M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA