G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

(2010) Giuseppe Rengo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

(2010) Petronila Penela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

Small Molecule Disruption of Gβγ Signaling Inhibits the Progression of Heart Failure

(2010) Liam M. Casey et al.   CIRCULATION RESEARCH

Dynamic Changes in Lymphocyte GRK2 Levels in Cardiac Transplant Patients: A Biomarker for Left Ventricular Function

(2010) Raphael E. Bonita et al.   CTS-Clinical and Translational Science

Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF-κB–Dependent Hypertrophic Gene Expression

(2010) Daniela Sorriento et al.   HYPERTENSION

Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

(2010) Anastasios Lymperopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gαq-mediated Activation of GRK2 by Mechanical Stretch in Cardiac Myocytes

(2010) Ricky Malhotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of impaired myocardial β-adrenergic receptor signaling by continuous-flow left ventricular assist device support

(2010) Shahab A. Akhter et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Functional Selectivity in Adrenergic and Angiotensin Signaling Systems

(2010) C. B. Patel et al.   MOLECULAR PHARMACOLOGY

Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease

(2010) Simon C. Malpas   PHYSIOLOGICAL REVIEWS

 -Arrestin-Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress

(2010) K. Rakesh et al.   Science Signaling

βARKct: A Therapeutic Approach for Improved Adrenergic Signaling and Function in Heart Disease

(2010) Henriette Brinks et al.   Journal of Cardiovascular Translational Research

Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2

(2009) Gavin E. Morris et al.   CARDIOVASCULAR RESEARCH

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance

(2009) Ersilia Cipolletta et al.   CARDIOVASCULAR RESEARCH

Heart Disease and Stroke Statistics—2010 Update

(2009) et al.   CIRCULATION

Negative Regulation of VEGF Signaling in Human Coronary Artery Endothelial Cells by G Protein-Coupled Receptor Kinase 5

(2009) Rui-Hai Zhou et al.   CTS-Clinical and Translational Science

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome

(2009) Letizia Spinelli et al.   EUROPEAN JOURNAL OF HEART FAILURE

G Protein–Coupled Receptor Kinase 2 Expression and Activity Are Associated With Blood Pressure in Black Americans

(2009) Heather I. Cohn et al.   HYPERTENSION

GRK mythology: G-protein receptor kinases in cardiovascular disease

(2009) Gerald W. Dorn   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances α1D-adrenergic receptor constriction

(2008) Heather Irina Cohn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myocardial Adeno-Associated Virus Serotype 6–βARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure

(2008) Giuseppe Rengo et al.   CIRCULATION

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

(2008) Philip W. Raake et al.   CIRCULATION RESEARCH

The Impact of  1-Adrenoceptors Up-Regulation Accompanied by the Impairment of  -Adrenergic Vasodilatation in Hypertension

(2008) E. Oliver et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Modulation of Adrenal Catecholamine Secretion by In Vivo Gene Transfer and Manipulation of G Protein–coupled Receptor Kinase-2 Activity

(2008) Anastasios Lymperopoulos et al.   MOLECULAR THERAPY

Tackling heart failure in the twenty-first century

(2008) James O. Mudd et al.   NATURE

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

(2008) Kristina Lorenz et al.   NATURE MEDICINE

A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure

(2008) Stephen B Liggett et al.   NATURE MEDICINE

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

(2008) J. S. Martini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA