Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals

Using deep learning to evaluate peaks in chromatographic data

(2019) Anne Bech Risum et al.   TALANTA

Optimization of integrated chromatography sequences for purification of biopharmaceuticals

(2019) Anton Löfgren et al.   BIOTECHNOLOGY PROGRESS

Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization

(2019) Shu-Ying Jing et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Reinforcement learning for batch bioprocess optimization

(2019) P. Petsagkourakis et al.   COMPUTERS & CHEMICAL ENGINEERING

Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry

(2018) Florian Füssl et al.   ANALYTICAL CHEMISTRY

An overview of experimental designs in HPLC method development and validation

(2018) Prafulla Kumar Sahu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Non-protein A purification platform for continuous processing of monoclonal antibody therapeutics

(2018) Nikhil Kateja et al.   JOURNAL OF CHROMATOGRAPHY A

Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks

(2017) Gang Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Discretized multi-level elution trajectory: A proof-of-concept demonstration

(2017) Anton Sellberg et al.   JOURNAL OF CHROMATOGRAPHY A

Optimizing Chemical Reactions with Deep Reinforcement Learning

(2017) Zhenpeng Zhou et al.   ACS Central Science

Development of Gradient Retention Model in Ion Chromatography. Part III: Fuzzy Logic QSRR Approach

(2015) Šime Ukić et al.   CHROMATOGRAPHIA

Rapid analysis of charge variants of monoclonal antibodies using non-linear salt gradient in cation-exchange high performance liquid chromatography

(2015) Varsha Joshi et al.   JOURNAL OF CHROMATOGRAPHY A

Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products

(2015) Vijesh Kumar et al.   JOURNAL OF CHROMATOGRAPHY A

Fast and accurate parameter sensitivities for the general rate model of column liquid chromatography

(2013) Andreas Püttmann et al.   COMPUTERS & CHEMICAL ENGINEERING

Determination of parameters for the steric mass action model—A comparison between two approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

Process analytical technology (PAT) for biopharmaceutical products

(2010) A. S. Rathore et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A fast and accurate solver for the general rate model of column liquid chromatography

(2010) Eric von Lieres et al.   COMPUTERS & CHEMICAL ENGINEERING

Reinforcement learning-based multi-agent system for network traffic signal control

(2010) I. Arel et al.   IET Intelligent Transport Systems

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Process analytical technology (PAT) for biopharmaceutical products: Part II. Concepts and applications

(2009) E.K. Read et al.   BIOTECHNOLOGY AND BIOENGINEERING

Process analytical technology (PAT) for biopharmaceutical products: Part I. concepts and applications

(2009) E.K. Read et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY