Local Interactions with the Glu166 Base and the Conformation of an Active Site Loop Play Key Roles in Carbapenem Hydrolysis by the KPC-2 β-lactamase

Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance

(2020) Cameron A. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

(2019) Christopher T. Lohans et al.   Scientific Reports

Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase

(2018) Xiang Zhai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Past and Present Perspectives on β-Lactamases

(2018) Karen Bush   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance

(2018) Meha P. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace

(2017) Latania K. Logan et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)

(2017) Orville A. Pemberton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates, Houston, Texas: Unexpected Abundance of Clonal Group 307

(2017) S. Wesley Long et al.   mBio

Structure–Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase

(2016) John P. Richard et al.   BIOCHEMISTRY

Modelling proteins’ hidden conformations to predict antibiotic resistance

(2016) Kathryn M. Hart et al.   Nature Communications

β-Lactams and β-Lactamase Inhibitors: An Overview

(2016) Karen Bush et al.   Cold Spring Harbor Perspectives in Medicine

β-Lactamases: A Focus on Current Challenges

(2016) Robert A. Bonomo   Cold Spring Harbor Perspectives in Medicine

Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder

(2015) Eynat Dellus-Gur et al.   JOURNAL OF MOLECULAR BIOLOGY

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

(2015) Shrenik C. Mehta et al.   PLoS Pathogens

Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study

(2015) Nikhil P. Krishnan et al.   PLoS One

What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs

(2013) Eynat Dellus-Gur et al.   JOURNAL OF MOLECULAR BIOLOGY

Magnitude and Origin of the Enhanced Basicity of the Catalytic Glutamate of Triosephosphate Isomerase

(2013) M. Merced Malabanan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metallo-β-lactamase structure and function

(2012) Timothy Palzkill   Annals of the New York Academy of Sciences

Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

(2012) Wei Ke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Basis for Carbapenem Hydrolysis by Class A β-Lactamases: A Combined Investigation using Crystallography and Simulations

(2012) Fátima Fonseca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Substrate Selectivity and a Novel Role in Inhibitor Discrimination by Residue 237 in the KPC-2  -Lactamase

(2010) K. M. Papp-Wallace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biochemical and Structural Characterization ofMycobacterium tuberculosisβ-Lactamase with the Carbapenems Ertapenem and Doripenem

(2010) Lee W. Tremblay et al.   BIOCHEMISTRY

Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

(2010) Karen Bush   CURRENT OPINION IN MICROBIOLOGY

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem

(2009) Kyle D. Schneider et al.   BIOCHEMISTRY

Three Decades of the Class A β-Lactamase Acyl-Enzyme

(2009) Jed Fisher et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A  -Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France

(2008) S. Petrella et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Carbapenems and SHV-1 β-Lactamase Form Different Acyl-Enzyme Populations in Crystals and Solution†

(2008) Matthew Kalp et al.   BIOCHEMISTRY

Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1

(2008) Michiyosi Nukaga et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY