Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability
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Title
Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability
Authors
Keywords
Hydrolysis, Antibiotic resistance, Antibiotics, Enzymes, Substitution mutation, Thermal stability, Penicillin, Enzyme kinetics
Journal
PLoS Pathogens
Volume 11, Issue 6, Pages e1004949
Publisher
Public Library of Science (PLoS)
Online
2015-06-02
DOI
10.1371/journal.ppat.1004949
References
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