Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma

A Disintegrin and Metalloproteinase 17 is required for ILC2 responses to IL-33

(2019) Joseph C. Lownik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

(2019) Nincy Debeuf et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Physiologic Response to Chronic House Dust Mite Exposure in Mice is Dependent on Lot Characteristics

(2019) Jaime M. Cyphert-Daly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ormdl3 and Allergic Asthma: from Physiology to Pathology

(2019) Briana James et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

(2019) Xue Jiang et al.   Frontiers in Cell and Developmental Biology

Acid sphingomyelinase regulates T H 2 cytokine release and bronchial asthma

(2019) Svenja Böll et al.   ALLERGY

The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent?

(2018) R. J. Snelgrove et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

(2018) Michelle M. Stein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB) /ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus

(2018) Parul H. Kothari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Role of Neutrophils in Asthma

(2018) Reynold A. Panettieri   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Metabolomics analysis identifies different metabotypes of asthma severity

(2017) Stacey N. Reinke et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary ORMDL3 is critical for induction of Alternaria -induced allergic airways disease

(2017) Stephan Löser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation

(2017) Steven Maltby et al.   RESPIROLOGY

Neutrophilic Inflammation in Asthma and Association with Disease Severity

(2017) Anuradha Ray et al.   TRENDS IN IMMUNOLOGY

Recent developments in the role of reactive oxygen species in allergic asthma

(2017) Jingjing Qu et al.   Journal of Thoracic Disease

House dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs

(2016) Tze Khee Chan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interaction of vitamin E isoforms on asthma and allergic airway disease

(2016) Joan Cook-Mills et al.   THORAX

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

(2016) Benjamin Joachim Schmiedel et al.   Nature Communications

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts

(2016) Michael C Peters et al.   Lancet Respiratory Medicine

Sphingolipids as cell fate regulators in lung development and disease

(2015) Joyce Lee et al.   APOPTOSIS

Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

(2015) Clement Oyeniran et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels

(2015) Michaela Schedel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care

(2015) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide

(2015) Ross Corriden et al.   Nature Communications

Airway Epithelium Interactions with Aeroallergens: Role of Secreted Cytokines and Chemokines in Innate Immunity

(2015) Vivek D. Gandhi et al.   Frontiers in Immunology

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Asthma Phenotypes: Nonallergic (Intrinsic) Asthma

(2014) Stephen P. Peters   Journal of Allergy and Clinical Immunology-In Practice

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48

(2013) Sung Gil Ha et al.   Nature Communications

Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo

(2012) Aimee Hoskins et al.   ALLERGY

RTP801 Is Required for Ceramide-Induced Cell-Specific Death in the Murine Lung

(2012) Krzysztof Kamocki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The effect of environmental oxidative stress on airway inflammation

(2012) Amy Auerbach et al.   Current Opinion in Allergy and Clinical Immunology

Airway TGF-β1 and oxidant stress in children with severe asthma: Association with airflow limitation

(2012) Sheena D. Brown et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

(2012) Megan M. Price et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion

(2011) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Safety of investigative bronchoscopy in the Severe Asthma Research Program

(2011) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epithelial Apoptosis and Loss in Airways of Children with Asthma

(2011) Chunju Zhou et al.   JOURNAL OF ASTHMA

Orchestrating house dust mite-associated allergy in the lung

(2011) Lisa G. Gregory et al.   TRENDS IN IMMUNOLOGY

Oxidative Stress in Asthma

(2011) Umit M Sahiner et al.   World Allergy Organization Journal

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment

(2009) S. Berdnikovs et al.   JOURNAL OF IMMUNOLOGY