Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation

(2016) Michelle L. Manni et al.   JOURNAL OF IMMUNOLOGY

TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus–Induced Exacerbations in a Mouse Model of Allergic Airways Disease

(2016) Thi Hiep Nguyen et al.   JOURNAL OF IMMUNOLOGY

Blomia tropicalis–Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13–Dependent Mechanism

(2016) Yen Leong Chua et al.   JOURNAL OF IMMUNOLOGY

Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ–Induced IL-27 and Airway Hyperresponsiveness in Mice

(2016) Wupeng Liao et al.   JOURNAL OF IMMUNOLOGY

Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation

(2016) Thi Hiep Nguyen et al.   PLoS One

Mouse models of acute exacerbations of allergic asthma

(2016) Rakesh K. Kumar et al.   RESPIROLOGY

Impaired Nuclear Translocation of the Glucocorticoid Receptor in Corticosteroid-Insensitive Airway Smooth Muscle in Severe Asthma

(2015) Po-Jui Chang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel concepts in airway inflammation and remodelling in asthma

(2015) Sejal Saglani et al.   EUROPEAN RESPIRATORY JOURNAL

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

(2015) Jing Jing Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

(2015) L Dejager et al.   Mucosal Immunology

Virus-induced modulation of lower airway diseases: Pathogenesis and pharmacologic approaches to treatment

(2015) Richard Leigh et al.   PHARMACOLOGY & THERAPEUTICS

Infections Caused by Chlamydophila pneumoniae

(2015) Irena Choroszy-Król et al.   Advances in Clinical and Experimental Medicine

Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33

(2014) A. M. Shadie et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations

(2014) Robert J. Snelgrove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

(2014) L. McKinley et al.   JOURNAL OF IMMUNOLOGY

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

Animal models of asthma: Reprise or reboot?

(2013) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease

(2013) MALCOLM R. STARKEY et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Development of a mouse model mimicking key aspects of a viral asthma exacerbation

(2013) Deborah L. Clarke et al.   CLINICAL SCIENCE

Respiratory syncytial virus and asthma

(2013) Giovanni Piedimonte   CURRENT OPINION IN PEDIATRICS

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

The emerging role of microRNAs in regulating immune and inflammatory responses in the lung

(2013) Paul S. Foster et al.   IMMUNOLOGICAL REVIEWS

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells

(2012) Alejandro Vazquez-Tello et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling

(2012) J Zhao et al.   Mucosal Immunology

Intranasal Administration of poly(I:C) and LPS in BALB/c Mice Induces Airway Hyperresponsiveness and Inflammation via Different Pathways

(2012) Magnus Starkhammar et al.   PLoS One

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

(2012) Rakesh K. Kumar et al.   Frontiers in Physiology

Diesel Exhaust Particulates Exacerbate Asthma-Like Inflammation by Increasing CXC Chemokines

(2011) Jiyoun Kim et al.   AMERICAN JOURNAL OF PATHOLOGY

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytokine/anti-cytokine therapy - novel treatments for asthma?

(2011) Philip M Hansbro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma

(2011) J. S. Siegle et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Personal Exposures to Traffic-Related Air Pollution and Acute Respiratory Health among Bronx Schoolchildren with Asthma

(2011) Ariel Spira-Cohen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Insights into asthmatic airway remodelling through murine models

(2011) SABA AL HEIALY et al.   RESPIROLOGY

Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease

(2011) Ama-Tawiah Essilfie et al.   PLoS Pathogens

Alveolar Macrophages Stimulate Enhanced Cytokine Production by Pulmonary CD4+ T-Lymphocytes in an Exacerbation of Murine Chronic Asthma

(2010) Cristan Herbert et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma

(2010) Timothy D. Le Cras et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TH17 Cells in Asthma and COPD

(2010) John F. Alcorn et al.   Annual Review of Physiology

Induction of glucocorticoid receptor-β expression in epithelial cells of asthmatic airways by T-helper type 17 cytokines

(2010) A. Vazquez-Tello et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia

(2010) Lisa G. Wood et al.   FREE RADICAL RESEARCH

Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology

(2010) M. Hew et al.   INTERNAL MEDICINE JOURNAL

Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro

(2010) Hye Young Yum et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

(2010) Jay C. Horvat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-27/IFN-  Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages

(2010) J. J. Li et al.   JOURNAL OF IMMUNOLOGY

Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease

(2010) J. C. Horvat et al.   JOURNAL OF IMMUNOLOGY

Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages

(2010) D. R. Nagarkar et al.   JOURNAL OF IMMUNOLOGY

Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite

(2010) Kate L. Tomlinson et al.   PLoS One

Short-Term Effects of PM 10 and NO 2 on Respiratory Health among Children with Asthma or Asthma-like Symptoms: A Systematic Review and Meta-Analysis

(2009) Gudrun Weinmayr et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Pathogenesis of Steroid-Resistant Airway Hyperresponsiveness: Interaction between IFN-  and TLR4/MyD88 Pathways

(2009) M. Yang et al.   JOURNAL OF IMMUNOLOGY

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen-sensitized mice

(2008) S. Kierstein et al.   ALLERGY

CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling

(2008) Taylor A. Doherty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Steroid-Resistant Neutrophilic Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

(2008) Kazuhiro Ito et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma

(2008) C. Herbert et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mouse models of allergic asthma: acute and chronic allergen challenge

(2008) A. T. Nials et al.   Disease Models & Mechanisms

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE