High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

(2021) Agnes Bonifacius et al.   IMMUNITY

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

(2021) Ivan O. Rosas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

(2021) Riyao Yang et al.   Nature Communications

Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19

(2021) Vincent J. Venditto et al.   Frontiers in Immunology

A neutrophil activation signature predicts critical illness and mortality in COVID-19

(2021) Matthew L. Meizlish et al.   Blood Advances

Interleukin 6, soluble interleukin 2 receptor alpha (CD25), monocyte colony-stimulating factor, and hepatocyte growth factor linked with systemic hyperinflammation, innate immunity hyperactivation, and organ damage in COVID-19 pneumonia

(2021) Luca Quartuccio et al.   CYTOKINE

Proteomic blood profiling in mild, severe and critical COVID-19 patients

(2021) Hamel Patel et al.   Scientific Reports

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

(2020) Jingyue Jia et al.   MOLECULAR CELL

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

(2020) Markus Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy

(2020) Paola Toniati et al.   AUTOIMMUNITY REVIEWS

Cytokine storm intervention in the early stages of COVID-19 pneumonia

(2020) Xinjuan Sun et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study

(2020) Corrado Campochiaro et al.   European Journal of Internal Medicine

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Ultra-high-resolution computed tomography can demonstrate alveolar collapse in novel coronavirus (COVID-19) pneumonia

(2020) Tae Iwasawa et al.   JAPANESE JOURNAL OF RADIOLOGY

Favipiravir, an antiviral for COVID-19?

(2020) Eric A Coomes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early

(2020) Chaochao Tan et al.   JOURNAL OF MEDICAL VIROLOGY

Elevated Interleukin‐6 and Severe COVID‐19: A Meta‐Analysis

(2020) Muhammad Aziz et al.   JOURNAL OF MEDICAL VIROLOGY

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19

(2020) Jecko Thachil et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

COVID-19 update: Covid-19-associated coagulopathy

(2020) Richard C. Becker   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Kidney disease is associated with in-hospital death of patients with COVID-19

(2020) Yichun Cheng et al.   KIDNEY INTERNATIONAL

New therapeutic opportunities for COVID-19 patients with Tocilizumab: Possible correlation of interleukin-6 receptor inhibitors with osteonecrosis of the jaws

(2020) Francesco Bennardo et al.   ORAL ONCOLOGY

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tocilizumab for Treatment of Severe COVID-19 Patients: Preliminary Results from SMAtteo COvid19 REgistry (SMACORE)

(2020) Marta Colaneri et al.   Microorganisms

Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients

(2020) Yaguang Zhang et al.   Cellular & Molecular Immunology

Acute kidney injury in critically ill patients with COVID-19

(2020) Paul Gabarre et al.   INTENSIVE CARE MEDICINE

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)

(2020) W. Joost Wiersinga et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Molecular pharmacology of ciclesonide against SARS-CoV-2

(2020) Hirokazu Kimura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

(2020) Jeremy K. Y. Yap et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis

(2020) Roberto Rossotti et al.   JOURNAL OF INFECTION

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy

(2020) Thomas A. Premeaux et al.   Frontiers in Immunology

Fataler COVID-19-Verlauf trotz IL‑6‑Rezeptor-Blockade im Zytokinsturm

(2020) M. Bovet et al.   ANAESTHESIST

Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size

(2020) Hong Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia

(2020) Lara Gibellini et al.   EMBO Molecular Medicine

Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure

(2020) T Ueland et al.   JOURNAL OF INFECTION

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Moderate Fever Cycles as a Potential Mechanism to Protect the Respiratory System in COVID-19 Patients

(2020) Anthony Guihur et al.   Frontiers in Medicine

Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease

(2020) Hamidreza Samaee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neutrophil more than platelet activation associates with thrombotic complications in COVID-19 patients

(2020) E Petito et al.   JOURNAL OF INFECTIOUS DISEASES

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relationship between serum osteopontin levels and the severity of COVID-19 infection

(2020) Ceyhun Varım et al.   WIENER KLINISCHE WOCHENSCHRIFT

The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes

(2020) Yvonne Adu-Agyeiwaah et al.   Cells

Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives

(2019) Gaowa Bai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1b stimulation

(2018) Takahiro Shimodaira et al.   CYTOKINE

Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection

(2018) Gaowa Bai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of osteopontin in kidney diseases

(2018) Beata Kaleta   INFLAMMATION RESEARCH

Serum levels of galectin-1, galectin-3 and galectin-9 are associated with large artery atherosclerotic stroke

(2017) Xin-Wei He et al.   Scientific Reports

Utility of Plasma Osteopontin Levels in Management of Community-Acquired Pneumonia

(2016) Jer-Hwa Chang et al.   International Journal of Medical Sciences

Plasma levels of Galectin-9 reflect disease severity in malaria infection

(2016) Bindongo P. P. Dembele et al.   MALARIA JOURNAL

IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3′-diindolylmethane in ovarian cancer cells

(2015) Minghua Zou et al.   CELLULAR ONCOLOGY

Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients

(2014) Beata Shiratori et al.   MEDIATORS OF INFLAMMATION

A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

(2014) Shigeyuki Kon et al.   PLoS One

Elevated levels of full-length and thrombin-cleaved osteopontin during acute dengue virus infection are associated with coagulation abnormalities

(2014) Haorile Chagan-Yasutan et al.   THROMBOSIS RESEARCH

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection

(2013) Haorile Chagan-Yasutan et al.   JOURNAL OF CLINICAL VIROLOGY

Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease

(2013) Yuko Kurose et al.   BMC Nephrology

Quinolone-Induced Upregulation of Osteopontin Gene Promoter Activity in Human Lung Epithelial Cell Line A549

(2012) Beata Shiratori et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid Decrease of Plasma Galectin-9 Levels in Patients with Acute HIV Infection after Therapy

(2012) Hiroki Saitoh et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Osteopontin Impairs Host Defense During Pneumococcal Pneumonia

(2011) Gerritje J. W. van der Windt et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Elevation of Plasma Osteopontin Levels in HIV Patients Despite Highly Active Antiretroviral Therapy

(2009) Haorile Chagan-Yasutan et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE