Identification of Anti-Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Oxysterol Derivatives In Vitro

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

Coronavirus replication factories

(2020) Andrea Du Toit   NATURE REVIEWS MICROBIOLOGY

A molecular pore spans the double membrane of the coronavirus replication organelle

(2020) Georg Wolff et al.   SCIENCE

THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS

(2020) Alessandro Marcello et al.   Redox Biology

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

(2020) Aled Edwards   Journal of Chemical Information and Modeling

New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies

(2020) Zhenfeng Zhang et al.   JOURNAL OF HEPATOLOGY

The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus

(2019) Ghada Shawli et al.   Viruses-Basel

Oxysterol research: a brief review

(2019) William J. Griffiths et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inhibition of Hedgehog Signaling in Fibroblasts, Pancreatic, and Lung Tumor Cells by Oxy186, an Oxysterol Analogue with Drug-Like Properties

(2019) Feng Wang et al.   Cells

Consensus and variations in cell line specificity among human metapneumovirus strains

(2019) Naganori Nao et al.   PLoS One

Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling

(2019) Stappenbeck et al.   Cells

25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes

(2018) Andrea Civra et al.   Redox Biology

The aryl hydrocarbon receptor–cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly

(2018) Hirofumi Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Oxy133, an osteogenic oxysterol, on new bone formation in rat two-level posterolateral fusion model

(2017) Zorica Buser et al.   EUROPEAN SPINE JOURNAL

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

(2017) Chunfeng Li et al.   IMMUNITY

Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol

(2017) Valeria Cagno et al.   Redox Biology

Endothelial cells, endoplasmic reticulum stress and oxysterols

(2017) F. Luchetti et al.   Redox Biology

Chloroquine could be used for the treatment of filoviral infections and other viral infections that emerge or emerged from viruses requiring an acidic pH for infectivity

(2016) Hephzibah Akpovwa   CELL BIOCHEMISTRY AND FUNCTION

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

(2015) Manabu Kaneko et al.   JOURNAL OF VIROLOGY

Comparison of a novel oxysterol molecule and rhBMP2 fusion rates in a rabbit posterolateral lumbar spine model

(2015) Trevor P. Scott et al.   Spine Journal

Virus-induced double-membrane vesicles

(2014) Emmanuelle Blanchard et al.   CELLULAR MICROBIOLOGY

A Novel Osteogenic Oxysterol Compound for Therapeutic Development to Promote Bone Growth: Activation of Hedgehog Signaling and Osteogenesis Through Smoothened Binding

(2014) Scott R Montgomery et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol

(2014) Andrea Civra et al.   Scientific Reports

Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP

(2013) Masashi Iwamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS