Oxysterol research: a brief review

A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase

(2018) Sacha Ferdinandusse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CHROMATOGRAPHY OF OXYSTEROLS

(2018) Irundika H.K. Dias et al.   BIOCHIMIE

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

(2018) Eamon FX Byrne et al.   CURRENT OPINION IN CELL BIOLOGY

Unravelling new pathways of sterol metabolism

(2018) Yuqin Wang et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation

(2018) William J. Griffiths et al.   JOURNAL OF LIPID RESEARCH

24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome

(2018) Ingemar Björkhem et al.   Frontiers in Neurology

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

(2018) Paula Merino-Serrais et al.   CEREBRAL CORTEX

Cilia-Associated Oxysterols Activate Smoothened

(2018) David R. Raleigh et al.   MOLECULAR CELL

Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma

(2018) William J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

(2018) William J. Griffiths et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cholesterol, Cholesterol-Lowering Medication Use, and Breast Cancer Outcome in the BIG 1-98 Study

(2017) Signe Borgquist et al.   JOURNAL OF CLINICAL ONCOLOGY

ACOX2 deficiency: An inborn error of bile acid synthesis identified in an adolescent with persistent hypertransaminasemia

(2017) Maria J. Monte et al.   JOURNAL OF HEPATOLOGY

Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study

(2017) Florence Dalenc et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Bile acid analysis in human disorders of bile acid biosynthesis

(2017) Frédéric. M. Vaz et al.   MOLECULAR ASPECTS OF MEDICINE

Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo

(2017) Morrie Lam et al.   MOLECULAR PHARMACOLOGY

Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice

(2017) Mahalakshmi Shankaran et al.   NEUROBIOLOGY OF DISEASE

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

(2017) Maud Voisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

(2017) Amy E. Baek et al.   Nature Communications

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

(2017) Gregory Segala et al.   Nature Communications

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

(2016) Lydie Boussicault et al.   BRAIN

On the importance of albumin binding for the flux of 7α-hydroxy-3-oxo-4-cholestenoic acid in the brain

(2016) Ahmed A. Saeed et al.   JOURNAL OF LIPID RESEARCH

Defective cholesterol metabolism in amyotrophic lateral sclerosis

(2016) Jonas Abdel-Khalik et al.   JOURNAL OF LIPID RESEARCH

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients

(2016) Peter J. Crick et al.   MOLECULAR NEUROBIOLOGY

ACOX2deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment

(2016) Sílvia Vilarinho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice

(2015) M. Valenza et al.   EMBO Molecular Medicine

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

(2015) Marie-Anne Burlot et al.   HUMAN MOLECULAR GENETICS

A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid

(2015) Rohini Sidhu et al.   JOURNAL OF LIPID RESEARCH

Validation of an isotope dilution gas chromatography–mass spectrometry method for combined analysis of oxysterols and oxyphytosterols in serum samples

(2015) Hans-Frieder Schött et al.   STEROIDS

Cholesterol metabolites exported from human brain

(2015) Luigi Iuliano et al.   STEROIDS

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain

(2014) Ahmed A. Saeed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholestenoic acids regulate motor neuron survival via liver X receptors

(2014) Spyridon Theofilopoulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols

(2014) Hanne Roberg-Larsen et al.   JOURNAL OF LIPID RESEARCH

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

(2014) Andrew J. Linsenbardt et al.   NEUROPHARMACOLOGY

Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels

(2014) A. R. Stiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation

(2014) P. Soroosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

(2013) Diego F. Cobice et al.   ANALYTICAL CHEMISTRY

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

(2012) Mathieu Blanc et al.   IMMUNITY

Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS

(2012) Frank P. Diekstra et al.   PLoS One

27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols

(2012) Robert J. Fakheri et al.   STEROIDS

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome

(2011) Libin Xu et al.   JOURNAL OF LIPID RESEARCH

A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma

(2011) Xuntian Jiang et al.   JOURNAL OF LIPID RESEARCH

Oxysterols direct B-cell migration through EBI2

(2011) Changlu Liu et al.   NATURE

Oxysterols direct immune cell migration via EBI2

(2011) Sébastien Hannedouche et al.   NATURE

Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism

(2010) Ratna Karuna et al.   ATHEROSCLEROSIS

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington’s disease

(2010) Daniel Del Toro et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

(2010) M. Valenza et al.   JOURNAL OF NEUROSCIENCE

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis

(2009) Rebecca Schüle et al.   JOURNAL OF LIPID RESEARCH

Oxysterols and neurodegenerative diseases

(2009) Ingemar Björkhem et al.   MOLECULAR ASPECTS OF MEDICINE

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

(2009) D. R. Bauman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease

(2008) Valerio Leoni et al.   BRAIN

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells

(2008) Jaya Prasanthi Rantham Prabhakara et al.   JOURNAL OF NEUROCHEMISTRY